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Mouse TSLP DuoSet ELISA, 15 Plate

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
Biotin

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Mouse TSLP DuoSet ELISA, 15 Plate Summary

Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
Tslp

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY555.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse TSLP DuoSet ELISA, 15 Plate

  • thymic stromal lymphopoietin
  • TSLP

Background

Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. The activities of mouse TSLP overlap with, but are distinct from, those of mouse IL-7. Both mouse TSLP and IL-7 can co-stimulate growth of thymocytes and mature T cells, and support B lymphopoiesis in long-term cultures of fetal liver cells and bone-marrow cells. Whereas mouse IL-7 facilitates the development of B220+/IgM- pre-B cells, mouse TSLP promotes the development B220+/IgM+ B cells. Human TSLP was reported to preferentially stimulate myeloid cells, inducing the release of T cell-attracting chemokines from monocytes and enhancing the maturation of CD11c+ dendritic cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence. Within the mature region, six of the seven cysteine residues present in the mouse TSLP involved in intramolecular disulfide bond formation are conserved in the human TSLP. Human TSLP shares approximately 43% aa sequence identity with mouse TSLP. By Northern blot analysis, human TSLP expression has been detected in many tissues with the highest expressions in heart, liver, testis and prostate. TSLP signals through a heterodimeric receptor complex that consists of IL-7 R alpha and the TSLP R, a member of the hemopoietin receptor family most closely related to Rgammac.

TSLP R, also named Delta and CRLM-2 (Cytokine Receptor-like Module-2), was originally cloned as a novel type 1 cytokine receptor with similarity to the common gamma chain (gamma c). It was subsequently identified as a subunit of the cellular receptor for the IL-7-like cytokine TSLP and termed TSLP R. TSLP R shows 24% sequence identity with the mouse gc receptor. TSLP R expression is constitutive in immune and hematopoietic cells, but is up-regulated in Th2 cells.

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Publications for TSLP (DY555)(19)

We have publications tested in 1 confirmed species: Mouse.


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Mouse
(19)
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Showing Publications 1 - 10 of 19. Show All 19 Publications.
Publications using DY555 Applications Species
Hussain, S;Majumder, N;Mazumder, MHH;Lewis, SE;Olapeju, O;Velayutham, M;Amin, MS;Brundage, K;Kelley, EE;Vanoirbeek, J; Intermittent ozone inhalation during house dust mite-induced sensitization primes for adverse asthma phenotype Redox biology 2024-10-01 [PMID: 39244793] (Mouse) Mouse
Yu, H;Zhang, C;Pan, H;Gao, X;Wang, X;Xiao, W;Yan, S;Gao, Y;Fu, J;Zhou, Y; Indeno[1,2,3-cd]pyrene enhances the sensitivity of airway epithelial cells to ferroptosis and aggravates asthma Chemosphere 2024-07-16 [PMID: 39025314] (Mouse) Mouse
J Segaud, W Yao, P Marschall, F Daubeuf, C Lehalle, B German, P Meyer, P Hener, C Hugel, E Flatter, M Guivarch, L Clauss, SF Martin, M Oulad-Abde, M Li Context-dependent function of TSLP and IL-1beta in skin allergic sensitization and atopic march Nature Communications, 2022-09-01;13(1):4703. 2022-09-01 [PMID: 36050303] (Mouse) Mouse
NJ Park, BG Jo, SK Bong, SA Park, S Lee, YK Kim, MH Yang, SN Kim Lobelia chinensis Extract and Its Active Compound, Diosmetin, Improve Atopic Dermatitis by Reinforcing Skin Barrier Function through SPINK5/LEKTI Regulation International Journal of Molecular Sciences, 2022-08-04;23(15):. 2022-08-04 [PMID: 35955819] (Mouse) Mouse
E Izumi, N Tanahashi, S Kinugasa, S Hidaka, N Zaima, T Moriyama Co-Application with Tannic Acid Prevents Transdermal Sensitization to Ovalbumin in Mice International Journal of Molecular Sciences, 2022-04-01;23(7):. 2022-04-01 [PMID: 35409304] (Mouse) Mouse
N Majumder, M Velayutham, D Bitounis, VK Kodali, MH Hasan Mazu, J Amedro, VV Khramtsov, A Erdely, T Nurkiewicz, P Demokritou, EE Kelley, S Hussain Oxidized carbon black nanoparticles induce endothelial damage through C-X-C chemokine receptor 3-mediated pathway Redox Biology, 2021-10-04;47(0):102161. 2021-10-04 [PMID: 34624601] (Mouse) Mouse
N Majumder, WT Goldsmith, VK Kodali, M Velayutham, SA Friend, VV Khramtsov, TR Nurkiewicz, A Erdely, PC Zeidler-Er, V Castranova, JR Harkema, EE Kelley, S Hussain Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure Redox Biology, 2021-08-05;46(0):102092. 2021-08-05 [PMID: 34418598] (Mouse) Mouse
JPK Mukendi, R Nakamura, S Uematsu, S Hamano Interleukin (IL)-33 is dispensable for Schistosoma mansoni worm maturation and the maintenance of egg-induced pathology in intestines of infected mice Parasites & vectors, 2021-01-22;14(1):70. 2021-01-22 [PMID: 33482904] (Mouse) Mouse
A Suhail, ZA Rizvi, P Mujagond, SA Ali, P Gaur, M Singh, V Ahuja, A Awasthi, CV Srikanth DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells Cell Rep, 2019-12-10;29(11):3522-3538.e7. 2019-12-10 [PMID: 31825833] (Mouse) Mouse
J Won, CH Gil, A Jo, HJ Kim Inhaled delivery of Interferon-lambda restricts epithelial-derived Th2 inflammation in allergic asthma Cytokine, 2019-03-09;119(0):32-36. 2019-03-09 [PMID: 30861490] (Mouse) Mouse
Show All 19 Publications.

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Bioinformatics

Gene Symbol Tslp