Mouse SCF Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Mature human SCF consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 36 aa cytoplasmic tail. The ECD shows both N-linked and O-linked glycosylation. Proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releases a 25 kDa soluble molecule which is comparable to the only form produced by Steel-dickie mutant mice. An alternately spliced isoform of human SCF lacks 28 aa that encompasses the primary proteolytic recognition site. Within the ECD of the short isoform (corresponding to this recombinant protein), human SCF shares 75 - 83% aa sequence identity with canine, feline, mouse, and rat SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells. Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF-R/c-kit to trigger receptor dimerization and signaling. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels.

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

Showing Publications 1 - 10 of 27. Show All 27 Publications. Collapse Publications.

Publications using MCK00	Applications	Species
Takeishi, S;Marchand, T;Koba, WR;Borger, DK;Xu, C;Guha, C;Bergman, A;Frenette, PS;Gritsman, K;Steidl, U; Haematopoietic stem cell numbers are not solely determined by niche availability bioRxiv : the preprint server for biology 2023-10-29 [PMID: 37961493] (Transgenic Mouse, Mouse)		Transgenic Mouse, Mouse
Molfetta, R;Lecce, M;Milito, ND;Putro, E;Pietropaolo, G;Marangio, C;Scarno, G;Moretti, M;De Smaele, E;Santini, T;Bernardini, G;Sciumè, G;Santoni, A;Paolini, R; SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment Cell death & disease 2023-09-20 [PMID: 37730723] (Mouse)		Mouse
Lee, HJ;Lee, J;Yang, MJ;Kim, YC;Hong, SP;Kim, JM;Hwang, GS;Koh, GY; Endothelial cell-derived stem cell factor promotes lipid accumulation through c-Kit-mediated increase of lipogenic enzymes in brown adipocytes Nature communications 2023-05-13 [PMID: 37179330] (Mouse)		Mouse
SY Heazlewood, T Ahmad, B Cao, H Cao, M Domingues, X Sun, CK Heazlewood, S Li, B Williams, M Fulton, JF White, T Nebl, CM Nefzger, JM Polo, BT Kile, F Kraus, MT Ryan, YB Sun, PFM Choong, SL Ellis, ML Anko, SK Nilsson High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production Nature Communications, 2023-04-13;14(1):2099. 2023-04-13 [PMID: 37055407] (Mouse)		Mouse
M Shah, H Kumar, S Qiu, H Li, M Harris, J He, A Abraham, DK Crossman, A Paterson, RS Welner, R Bhatia Low c-Kit expression identifies primitive therapy-resistant CML stem cells JCI Insight, 2023-01-10;0(0):. 2023-01-10 [PMID: 36413413] (Mouse)		Mouse
JC Huang, SC Chen, WA Chang, WW Hung, PH Wu, LY Wu, JM Chang, YL Hsu, YC Tsai KITLG Promotes Glomerular Endothelial Cell Injury in Diabetic Nephropathy by an Autocrine Effect International Journal of Molecular Sciences, 2022-10-03;23(19):. 2022-10-03 [PMID: 36233032] (Human, Mouse)		Human, Mouse
Y Omatsu, S Aiba, T Maeta, K Higaki, K Aoki, H Watanabe, G Kondoh, R Nishimura, S Takeda, UI Chung, T Nagasawa Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells Nature Communications, 2022-05-12;13(1):2654. 2022-05-12 [PMID: 35551452] (Mouse)		Mouse
BM Foster, KL Langsten, A Mansour, L Shi, BA Kerr Tissue distribution of stem cell factor in adults Experimental and molecular pathology, 2021-08-24;122(0):104678. 2021-08-24 [PMID: 34450114] (Mouse)		Mouse
AA Hastreiter, GG Dos Santos, EN Makiyama, EWC Santos, P Borelli, RA Fock Effects of protein malnutrition on haematopoietic regulatory activity of bone marrow mesenchymal stem cells The Journal of nutritional biochemistry, 2021-03-08;0(0):108626. 2021-03-08 [PMID: 33705953] (Mouse)		Mouse
S Sinha, M Biswas, SS Chatterjee, S Kumar, A Sengupta Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-&beta Signaling Cell Rep, 2020-04-28;31(4):107570. 2020-04-28 [PMID: 32348751] (Mouse)		Mouse
W Fonseca, AJ Rasky, C Ptaschinsk, SH Morris, SKK Best, M Phillips, CA Malinczak, NW Lukacs Group 2 innate lymphoid cells (ILC2) are regulated by stem cell factor during chronic asthmatic disease Mucosal Immunol, 2019-01-07;12(2):445-456. 2019-01-07 [PMID: 30617299] (Mouse)		Mouse
M Mastri, CR Lee, A Tracz, RS Kerbel, M Dolan, Y Shi, JML Ebos Tumor-independent host secretomes induced by angiogenesis and immune-checkpoint inhibitors Mol. Cancer Ther., 2018-04-25;0(0):. 2018-04-25 [PMID: 29695634] (Mouse)		Mouse
First steps to define murine amniotic fluid stem cell microenvironment Sci Rep, 2016-11-15;6(0):37080. 2016-11-15 [PMID: 27845396] (Mouse)		Mouse
Cunha M, Lima F, Vinolo M, Hastreiter A, Curi R, Borelli P, Fock R Protein malnutrition induces bone marrow mesenchymal stem cells commitment to adipogenic differentiation leading to hematopoietic failure. PLoS ONE, 2013-03-14;8(3):e58872. 2013-03-14 [PMID: 23516566] (Mouse)		Mouse
Arcangeli ML, Frontera V, Bardin F, Obrados E, Adams S, Chabannon C, Schiff C, Mancini SJ, Adams RH, Aurrand-Lions M JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow. Blood, 2011-08-25;118(17):4609-19. 2011-08-25 [PMID: 21868569] (Mouse)		Mouse
Horiuchi K, Morioka H, Takaishi H, Akiyama H, Blobel CP, Toyama Y Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme. J. Immunol., 2009-06-15;182(12):7408-14. 2009-06-15 [PMID: 19494263] (Mouse)		Mouse
Suh HC, Ji M, Gooya J, Lee M, Klarmann KD, Keller JR Cell-nonautonomous function of Id1 in the hematopoietic progenitor cell niche. Blood, 2009-05-28;114(6):1186-95. 2009-05-28 [PMID: 19478045] (Mouse)		Mouse
Schroeter MR, Humboldt T, Schafer K, Konstantinides S Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice. Atherosclerosis, 2008-11-25;205(1):63-73. 2008-11-25 [PMID: 19111832] (Mouse)		Mouse
Higuchi K, Ayach B, Sato T, Chen M, Devine SP, Rasaiah VI, Dawood F, Yanagisawa T, Tei C, Takenaka T, Liu PP, Medin JA Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction. Mol. Ther., 2008-11-11;17(2):262-8. 2008-11-11 [PMID: 19002160] (Mouse)		Mouse
Huang B, Lei Z, Zhang GM, Li D, Song C, Li B, Liu Y, Yuan Y, Unkeless J, Xiong H, Feng ZH SCF-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment. Blood, 2008-06-04;112(4):1269-79. 2008-06-04 [PMID: 18524989] (Mouse)		Mouse
Zhang P, Nelson S, Bagby GJ, Siggins R, Shellito JE, Welsh DA The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice. Stem Cells, 2008-05-15;26(7):1778-86. 2008-05-15 [PMID: 18483422] (Mouse)		Mouse
Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc. Natl. Acad. Sci. U.S.A., 2007-10-17;104(43):17069-74. 2007-10-17 [PMID: 17942672] (Mouse)		Mouse
Pan PY, Wang GX, Yin B, Ozao J, Ku T, Divino CM, Chen SH Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood, 2007-09-20;111(1):219-28. 2007-09-20 [PMID: 17885078] (Mouse)		Mouse
Wang CH, Verma S, Hsieh IC, Chen YJ, Kuo LT, Yang NI, Wang SY, Wu MY, Hsu CM, Cheng CW, Cherng WJ Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system. J. Mol. Cell. Cardiol., 2006-05-05;41(1):34-43. 2006-05-05 [PMID: 16678199] (Mouse)		Mouse
Liao HF, Chen YJ, Yang YC A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression. Life Sci., 2005-02-25;77(4):400-13. 2005-02-25 [PMID: 15894009] (Mouse)		Mouse
Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MA, Werb Z, Rafii S Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell, 2002-05-31;109(5):625-37. 2002-05-31 [PMID: 12062105] (Mouse)		Mouse
Shih CC, Hu MC, Hu J A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells. Blood, 2000-03-15;95(6):1957-66. 2000-03-15 [PMID: 10706861] (Mouse)		Mouse
Show All 27 Publications. Collapse Publications.

Array MCK00

• SCF/c-kit Ligand Antibodies
• SCF/c-kit Ligand ELISA Kits
• SCF/c-kit Ligand Lysate
• SCF/c-kit Ligand Proteins
• SCF/c-kit Ligand ELISAs
• SCF/c-kit Ligand Proteins and Enzymes