Mouse S100A8/S100A9 Heterodimer DuoSet ELISA, 5 Plate

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S100A8 (also MRP8 and calgranulin A) is a 10 kDa member of the S100 family, EF-hand superfamily of Ca-binding proteins. It is produced by neutrophils and monocytes, and forms Ca²⁺-dependent heterodimer/heterotetramer complexes (termed calprotectin) with S100A9. It functions both intracellularly and extracellularly, where it binds to RAGE and CD36. Human S100A8 is 93 amino acids (aa) in length. It contains two EF-hand motifs (aa 12 - 47 and 46 - 81) and one high-affinity Ca²⁺-binding site (aa 59 - 70). There may be one splice form that shows a 15 aa substitution for the C-terminal 14 amino acids. Although mouse S100A8 is cleaved by MMP-2 after Asn21, it is unclear if human S100A8 is susceptible. Full-length human S100A8 is 57% and 74% aa identical to mouse and canine S100A8, respectively.

We have publications tested in 2 confirmed species: Mouse, Transgenic Mouse.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using DY8596-05	Applications	Species
Nabukhotna, K;Kordus, SL;Shupe, JA;Cano Rodríguez, R;Smith, A;Bohannon, JK;Washington, MK;Lacy, DB; Purified CDT toxins and a clean deletion within the CDT locus provide novel insights into the contribution of binary toxin in cellular inflammation and Clostridioides difficile infection PLoS pathogens 2024-09-19 [PMID: 39298531] (Mouse)		Mouse
Fishbein, SRS;DeVeaux, AL;Khanna, S;Ferreiro, AL;Liao, J;Agee, W;Ning, J;Mahmud, B;Wallace, MJ;Hink, T;Reske, KA;Guruge, J;Leekha, S;Dubberke, ER;Dantas, G; Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization bioRxiv : the preprint server for biology 2024-07-11 [PMID: 39026847] (Mouse)		Mouse
Pham, HTT;Magez, S;Choi, B;Baatar, B;Jung, J;Radwanska, M; Neutrophil metalloproteinase driven spleen damage hampers infection control of trypanosomiasis Nature communications 2023-09-05 [PMID: 37669943] (Mouse)		Mouse
Kocatürk, B;Lee, Y;Nosaka, N;Abe, M;Martinon, D;Lane, ME;Moreira, D;Chen, S;Fishbein, MC;Porritt, RA;Franklin, BS;Noval Rivas, M;Arditi, M; Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis JCI insight 2023-06-06 [PMID: 37279077] (Mouse)		Mouse
Li, C;Ture, SK;Nieves-Lopez, B;Blick-Nitko, SK;Maurya, P;Livada, AC;Stahl, TJ;Kim, M;Pietropaoli, AP;Morrell, CN; Thrombocytopenia Independently Leads to Monocyte Immune Dysfunction bioRxiv : the preprint server for biology 2023-05-12 [PMID: 37214993] (Mouse)		Mouse
L Chen, V Shi, S Wang, R Freeman, F Ruiz, K Jayachandr, J Zhang, P Cosper, L Sun, CJ Luke, C Spina, PW Grigsby, JK Schwarz, S Markovina SCCA1/SERPINB3 promotes suppressive immune environment via STAT-dependent chemokine production, blunting the therapy-induced T cell responses bioRxiv : the preprint server for biology, 2023-02-03;0(0):. 2023-02-03 [PMID: 36778224] (Mouse)		Mouse
JC Yang, JP Jacobs, M Hwang, S Sabui, F Liang, HM Said, J Skupsky Biotin Deficiency Induces Intestinal Dysbiosis Associated with an Inflammatory Bowel Disease-like Phenotype Nutrients, 2023-01-04;15(2):. 2023-01-04 [PMID: 36678135] (Mouse)		Mouse
M Zhao, K Okunishi, Y Bu, O Kikuchi, H Wang, T Kitamura, T Izumi Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders JCI Insight, 2023-02-22;0(0):. 2023-02-22 [PMID: 36626233] (Mouse)		Mouse
RA Keogh, AL Haeberle, CJ Langouët-A, JS Kavanaugh, EP Schmidt, GD Moore, AR Horswill, KS Doran Group B Streptococcus adaptation promotes survival in a hyperinflammatory diabetic wound environment Science Advances, 2022-11-11;8(45):eadd3221. 2022-11-11 [PMID: 36367946] (Mouse, Transgenic Mouse)		Mouse, Transgenic Mouse
HG Roweth, MW Malloy, GJ Goreczny, IC Becker, Q Guo, EA Mittendorf, JE Italiano, SS McAllister, EM Battinelli Pro-inflammatory megakaryocyte gene expression in murine models of breast cancer Science Advances, 2022-10-12;8(41):eabo5224. 2022-10-12 [PMID: 36223471] (Mouse)		Mouse
W Yao, B German, D Chraa, A Braud, C Hugel, P Meyer, G Davidson, P Laurette, G Mengus, E Flatter, P Marschall, J Segaud, M Guivarch, P Hener, MC Birling, D Lipsker, I Davidson, M Li Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment JCI Insight, 2022-11-08;0(0):. 2022-11-08 [PMID: 36107619] (Mouse)		Mouse
S Talley, R Valiauga, L Anderson, AR Cannon, MA Choudhry, EM Campbell DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod Journal of Neuroinflammation, 2021-11-10;18(1):263. 2021-11-10 [PMID: 34758843] (Mouse)		Mouse
AM Porras, Q Shi, H Zhou, R Callahan, G Montenegro, N Solomons, IL Brito Geographic differences in gut microbiota composition impact susceptibility to enteric infection Cell Reports, 2021-07-27;36(4):109457. 2021-07-27 [PMID: 34320343] (Mouse)		Mouse
E Salameh, M Jarbeau, FB Morel, M Zeilani, M Aziz, P Déchelotte, R Marion-Let Modeling undernutrition with enteropathy in mice Sci Rep, 2020-09-24;10(1):15581. 2020-09-24 [PMID: 32973261] (Mouse)		Mouse
WW Lim, B Ng, A Widjaja, C Xie, L Su, N Ko, SY Lim, XY Kwek, S Lim, SA Cook, S Schafer Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice PLoS ONE, 2020-01-09;15(1):e0227505. 2020-01-09 [PMID: 31917819] (Mouse)		Mouse
N Gao, R Me, C Dai, B Seyoum, FX Yu Opposing Effects of IL-1Ra and IL-36Ra on Innate Immune Response to Pseudomonas aeruginosa Infection in C57BL/6 Mouse Corneas J. Immunol., 2018-06-11;0(0):. 2018-06-11 [PMID: 29891552] (Mouse)		Mouse
X Zhang, L Wei, J Wang, Z Qin, J Wang, Y Lu, X Zheng, Q Peng, Q Ye, F Ai, P Liu, S Wang, G Li, S Shen, J Ma Suppression Colitis and Colitis-Associated Colon Cancer by Anti-S100a9 Antibody in Mice Front Immunol, 2017-12-13;8(0):1774. 2017-12-13 [PMID: 29326691] (Mouse)		Mouse
BX Ross, N Gao, X Cui, TJ Standiford, J Xu, FX Yu IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas J. Immunol, 2017-03-22;0(0):. 2017-03-22 [PMID: 28330899] (Mouse)		Mouse
Show All 18 Publications. Collapse Publications.

Array DY8596-05

• S100A8/S100A9 Heterodimer Antibodies
• S100A8/S100A9 Heterodimer ELISAs
• S100A8/S100A9 Heterodimer Proteins and Enzymes