Mouse/Rat Osteopontin (OPN) Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Osteopontin (OPN), also known as bone sialoprotein (BSP), is a secreted SIBLING family protein that can be variably modified by O- and N-glycosylation, sulfation, phosphorylation, and transglutamination. OPN is widely expressed and is prominent in mineralized tissues. It inhibits bone mineralization and kidney stone formation and promotes inflammation, cell ad¬hesion, and migration. Its expression is upregulat¬ed during inflammation, obesity, atherosclerosis, cancer, and tissue damage and contributes to the pathophysiology of these conditions. The central region of OPN contains RGD and non-RGD binding sites for multiple integrins. Adjacent to the RGD motif is the sequence SLAYGLR (SVVYGLR in human) which serves as a cryptic binding site for additional integrins: it is masked in full length OPN but is exposed following OPN cleavage by multiple proteases in tumors and sites of tissue injury.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

Showing Publications 1 - 10 of 44. Show All 44 Publications. Collapse Publications.

Publications using MOST00	Applications	Species
Costa, KLD;Abreu, LF;Tolomei, CB;Eleutério, RG;Basting, R;Balbinot, G;Collares, FM;Lopes, P;Veiga, N;Fernandes, GVO;Peruzzo, DC; Use of Local Melatonin with Xenogeneic Bone Graft to Treat Critical-Size Bone Defects in Rats with Osteoporosis: A Randomized Study Journal of functional biomaterials 2024-05-13 [PMID: 38786635] (Rat)		Rat
KG English, AL Reid, A Samani, GJF Coulis, SA Villalta, CJ Walker, S Tamir, MS Alexander Next-Generation SINE Compound KPT-8602 Ameliorates Dystrophic Pathology in Zebrafish and Mouse Models of DMD Biomedicines, 2022-09-26;10(10):. 2022-09-26 [PMID: 36289662] (Mouse)		Mouse
MJ Coyne, AE Schultze, DJ McCrann, RE Murphy, J Cross, M Strong-Tow, C Drake, R Mack Evaluation of renal injury and function biomarkers, including symmetric dimethylarginine (SDMA), in the rat passive Heymann nephritis (PHN) model PLoS ONE, 2022-05-27;17(5):e0269085. 2022-05-27 [PMID: 35622875] (Rat)		Rat
O Mucha, K Kaziród, P Podkalicka, K Rusin, J Dulak, A ?oboda Dysregulated Autophagy and Mitophagy in a Mouse Model of Duchenne Muscular Dystrophy Remain Unchanged Following Heme Oxygenase-1 Knockout International Journal of Molecular Sciences, 2021-12-31;23(1):. 2021-12-31 [PMID: 35008897] (Mouse)		Mouse
X Jiang, F Zhang, X Ji, F Dong, H Yu, M Xue, Y Qiu, F Yang, X Hu, Z Bao Lipid-injured hepatocytes release sOPN to improve macrophage migration via CD44 engagement and pFak-NF&kappaB signaling Cytokine, 2021-02-27;142(0):155474. 2021-02-27 [PMID: 33647584] (Human, Mouse)		Human, Mouse
K Ritter, K Jung, C Dolderer, D Appel, CC Oswald, U Ritz, MKE Schäfer Early Reciprocal Effects in a Murine Model of Traumatic Brain Injury and Femoral Fracture Mediators of Inflammation, 2021-01-18;2021(0):8835730. 2021-01-18 [PMID: 33531878] (Mouse)		Mouse
TA Pereira, G Vaz de Mel, E Trindade S, FE Pereira, M Maria de S Praziquantel pharmacotherapy reduces systemic osteopontin levels and liver collagen content in murine schistosomiasis mansoni International journal for parasitology, 2021-01-23;0(0):. 2021-01-23 [PMID: 33493521] (Mouse)		Mouse
A Frasca, Y Xue, AP Kossar, S Keeney, C Rock, A Zakharchen, M Streeter, RC Gorman, JB Grau, I George, JE Bavaria, A Krieger, DA Spiegel, RJ Levy, G Ferrari Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves JACC Basic Transl Sci, 2020-08-05;5(8):755-766. 2020-08-05 [PMID: 32875167] (Rat)		Rat
K Kohl, E Herzog, G Dickneite, S Pestel Evaluation of urinary biomarkers for early detection of acute kidney injury in a rat nephropathy model J Pharmacol Toxicol Methods, 2020-08-07;0(0):106901. 2020-08-07 [PMID: 32771565] (Rat)		Rat
B Gómez-Sant, D Saenz de U, M Nuñez-Garc, F Gonzalez-R, X Buque, I Aurrekoetx, V Gutiérrez, MJ Gonzalez-R, C García-Mon, Á González-R, L Mosteiro, G Errazti, P Mifsut, S Gaztambide, L Castaño, C Martin, R Nogueiras, ML Martinez-C, WK Syn, P Aspichueta Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease Aging Cell, 2020-07-07;0(0):e13183. 2020-07-07 [PMID: 32638492] (Mouse)		Mouse
J Wilflingse, M Willi, HK Lee, H Olauson, J Jankowski, T Ichimura, R Erben, MT Valerius, L Hennighaus, JV Bonventre Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury Nat Commun, 2020-07-07;11(1):3383. 2020-07-07 [PMID: 32636391] (Mouse)		Mouse
PG Hitscheric, LH Xie, D Del Re, EJ Lee The effects of macrophages on cardiomyocyte calcium-handling function using in vitro culture models Physiol Rep, 2019-07-01;7(13):e14137. 2019-07-01 [PMID: 31301118] (Mouse)		Mouse
B Giri, VK Gupta, B Yaffe, S Modi, P Roy, V Sethi, SP Lavania, SM Vickers, V Dudeja, S Banerjee, J Watts, A Saluja Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia J Transl Med, 2019-05-20;17(1):163. 2019-05-20 [PMID: 31109340] (Human)		Human
E Giraud, E Rouault, L Fiette, JH Colle, D Smirlis, E Melanitou Osteopontin in the host response to Leishmania amazonensis BMC Microbiol., 2019-02-08;19(1):32. 2019-02-08 [PMID: 30736736] (Mouse)		Mouse
J Wang, J Huang, M Zhu, S Chen, C Chen, C Miao, H He, Y Song Osteopontin potentiates PM-induced IL-1? and IL-1? production via the ERK/JNK signaling pathway Ecotoxicol. Environ. Saf., 2019-01-09;171(0):467-474. 2019-01-09 [PMID: 30639873] (Mouse)		Mouse
JD Klement, AV Paschall, PS Redd, ML Ibrahim, C Lu, D Yang, E Celis, SI Abrams, K Ozato, K Liu An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion J. Clin. Invest., 2018-11-05;0(0):. 2018-11-05 [PMID: 30395540] (Mouse)		Mouse
MN Lee, HS Hwang, SH Oh, A Roshanzade, JW Kim, JH Song, ES Kim, JT Koh Elevated extracellular calcium ions promote proliferation and migration of mesenchymal stem cells via increasing osteopontin expression Exp. Mol. Med., 2018-11-05;50(11):142. 2018-11-05 [PMID: 30393382] (Mouse)		Mouse
E De Giglio, MA Bonifacio, AM Ferreira, S Cometa, ZY Ti, A Stanzione, K Dalgarno, P Gentile Multi-compartment scaffold fabricated via 3D-printing as in vitro co-culture osteogenic model Sci Rep, 2018-10-11;8(1):15130. 2018-10-11 [PMID: 30310164] (Mouse)		Mouse
M Nuñez-Garc, B Gomez-Sant, D Saenz de U, D Mestre, F Gonzalez-R, X Buque, V Gutiérrez-, ML Martinez-C, WK Syn, O Fresnedo, P Aspichueta Atorvastatin provides a new lipidome improving early regeneration after partial hepatectomy in osteopontin deficient mice Sci Rep, 2018-10-02;8(1):14626. 2018-10-02 [PMID: 30279550] (Mouse)		Mouse
M Mastri, CR Lee, A Tracz, RS Kerbel, M Dolan, Y Shi, JML Ebos Tumor-independent host secretomes induced by angiogenesis and immune-checkpoint inhibitors Mol. Cancer Ther., 2018-04-25;0(0):. 2018-04-25 [PMID: 29695634] (Mouse)		Mouse
ZV Varga, K Erdelyi, J Paloczi, R Cinar, ZK Zsengeller, T Jourdan, C Matyas, NT Balazs, A Guillot, X Xiang, A Mehal, G Hasko, IE Stillman, S Rosen, B Gao, G Kunos, P Pacher Disruption of renal arginine metabolism promotes kidney injury in hepatorenal syndrome Hepatology, 2018-10-01;0(0):. 2018-10-01 [PMID: 29631342] (Mouse)		Mouse
LA O'Reilly, TL Putoczki, LA Mielke, JT Low, A Lin, A Preaudet, MJ Herold, K Yaprianto, L Tai, A Kueh, G Pacini, RL Ferrero, R Gugasyan, Y Hu, M Christie, S Wilcox, R Grumont, MDW Griffin, L O'Connor, GK Smyth, M Ernst, P Waring, S Gerondakis, A Strasser Loss of NF-?B1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner Immunity, 2018-03-20;48(3):570-583.e8. 2018-03-20 [PMID: 29562203] (Mouse)		Mouse
F Blanco, SE Heinonen, E Gurzeler, LM Berglund, AM Dutius And, O Kotova, AC Jönsson-Ry, S Ylä-Herttu, MF Gomez In vivo inhibition of nuclear factor of activated T-cells leads to atherosclerotic plaque regression in IGF-II/LDLR-/-ApoB100/100mice Diab Vasc Dis Res, 2018-03-02;0(0):1479164118759. 2018-03-02 [PMID: 29499628] (Mouse)		Mouse
N Wilck, L Markó, A Balogh, K Kräker, F Herse, H Bartolomae, IA Szijártó, M Gollasch, N Reichhart, O Strauss, A Heuser, D Brockschni, A Kretschmer, R Lesche, F Sohler, JP Stasch, P Sandner, FC Luft, DN Müller, R Dechend, N Haase Nitric oxide-sensitive guanylyl cyclase stimulation improves experimental heart failure with preserved ejection fraction JCI Insight, 2018-02-22;3(4):. 2018-02-22 [PMID: 29467337] (Rat)		Rat
K Fu, Y Miyamoto, K Otake, K Sumi, E Saika, S Matsumura, N Sato, Y Ueno, S Seo, K Uno, SI Muramatsu, A Nitta Involvement of the accumbal osteopontin-interacting transmembrane protein 168 in methamphetamine-induced place preference and hyperlocomotion in mice Sci Rep, 2017-10-12;7(1):13084. 2017-10-12 [PMID: 29026117] (Mouse)		Mouse
A Aarup, CH Nielsen, LS Bisgaard, I Bot, HH El-Ali, A Kjaer, LB Nielsen, TX Pedersen Uremia does not affect neointima formation in mice Sci Rep, 2017-07-26;7(1):6496. 2017-07-26 [PMID: 28747676] (Mouse)		Mouse
GM Pio, Y Xia, MM Piaseczny, JE Chu, AL Allan Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells PLoS ONE, 2017-05-12;12(5):e0177640. 2017-05-12 [PMID: 28498874] (Mouse)		Mouse
J Grzesiak, A ?mieszek, K Marycz Ultrastructural changes during osteogenic differentiation in mesenchymal stromal cells cultured in alginate hydrogel Cell Biosci, 2017-01-03;7(0):2. 2017-01-03 [PMID: 28066541] (Rat)		Rat
Fuquan Jin Deficient TSC1/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complex Hum. Mol. Genet, 2017-01-15;0(0):. 2017-01-15 [PMID: 28013293] (Mouse)		Mouse
The P2X4 receptor is required for neuroprotection via ischemic preconditioning Sci Rep, 2016-05-13;6(0):25893. 2016-05-13 [PMID: 27173846] (Mouse)		Mouse
Age-associated vascular inflammation promotes monocytosis during atherogenesis Aging Cell, 2016-05-02;0(0):. 2016-05-02 [PMID: 27135421] (Mouse)		Mouse
Huang H, Ma M High Sodium-Induced Oxidative Stress and Poor Anticrystallization Defense Aggravate Calcium Oxalate Crystal Formation in Rat Hyperoxaluric Kidneys. PLoS ONE, 2015-08-04;10(8):e0134764. 2015-08-04 [PMID: 26241473] (Rat)		Rat
Zetterqvist A, Blanco F, Ohman J, Kotova O, Berglund L, de Frutos Garcia S, Al-Naemi R, Wigren M, McGuire P, Gonzalez Bosc L, Gomez M Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice. J Diabetes Res, 2015-03-31;2015(0):428473. 2015-03-31 [PMID: 25918731] (Mouse)		Mouse
Zelenchuk L, Hedge A, Rowe P PHEX mimetic (SPR4-peptide) corrects and improves HYP and wild type mice energy-metabolism. PLoS ONE, 2014-05-19;9(5):e97326. 2014-05-19 [PMID: 24839967] (Mouse)		Mouse
Chang S, Song S, Lee J, Yoon J, Park J, Choi S, Park J, Choi K, Choi C Phenotypic modulation of primary vascular smooth muscle cells by short-term culture on micropatterned substrate. PLoS ONE, 2014-02-04;9(2):e88089. 2014-02-04 [PMID: 24505388] (Rat)		Rat
Brampton C, Aherrahrou Z, Chen L, Martin L, Bergen A, Gorgels T, Erdmann J, Schunkert H, Szabo Z, Varadi A, Le Saux O The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury. Am J Pathol, 2014-01-01;184(1):159-70. 2014-01-01 [PMID: 24479134] (Mouse)		Mouse
Chen J, Doroudi M, Cheung J, Grozier A, Schwartz Z, Boyan B Plasma membrane Pdia3 and VDR interact to elicit rapid responses to 1alpha,25(OH)(2)D(3). Cell Signal, 2013-07-27;25(12):2362-73. 2013-07-27 [PMID: 23896121] (Mouse)		Mouse
Shojaei F, Scott N, Kang X, Lappin PB, Fitzgerald AA, Karlicek S, Simmons BH, Wu A, Lee JH, Bergqvist S, Kraynov E Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer. J. Exp. Clin. Cancer Res., 2012-03-23;31(0):26. 2012-03-23 [PMID: 22444159] (Mouse)		Mouse
Schupp N, Kolkhof P, Queisser N, Gartner S, Schmid U, Kretschmer A, Hartmann E, Oli RG, Schafer S, Stopper H Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats. FASEB J., 2010-12-06;25(3):968-78. 2010-12-06 [PMID: 21135038] (Rat)		Rat
Chen J, Olivares-Navarrete R, Wang Y Protein-disulfide isomerase-associated 3 (Pdia3) mediates the membrane response to 1,25-dihydroxyvitamin D3 in osteoblasts. J. Biol. Chem., 2010-09-15;285(47):37041-50. 2010-09-15 [PMID: 20843786] (Mouse)		Mouse
Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, Saemann MD, Geyeregger R, Schlederer M, Kenner L, Stulnig TM Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance. Diabetes, 2010-01-27;59(4):935-46. 2010-01-27 [PMID: 20107108] (Mouse)		Mouse
Takanashi M, Oikawa K, Sudo K, Tanaka M, Fujita K, Ishikawa A, Nakae S, Kaspar RL, Matsuzaki M, Kudo M, Kuroda M Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse. Gene Ther., 2009-05-28;16(8):982-9. 2009-05-28 [PMID: 19474812] (Mouse)		Mouse
Shao J, Washington MK, Saxena R, Sheng H Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin. Carcinogenesis, 2007-08-11;28(12):2476-83. 2007-08-11 [PMID: 17693663] (Rat)		Rat
Briscoe CP, Looper D, Tran P, Herrera J, McDonnell SR, Bhat BG LPS-induced biomarkers in mice: a potential model for identifying insulin sensitizers. Biochem. Biophys. Res. Commun., 2007-07-10;361(1):140-5. 2007-07-10 [PMID: 17659259] (Mouse)		Mouse
Show All 44 Publications. Collapse Publications.

Array MOST00

• Osteopontin/OPN Antibodies
• Osteopontin/OPN ELISA Kit
• Osteopontin/OPN Lysates
• Osteopontin/OPN Proteins
• Osteopontin/OPN Proteins and Enzymes
• Osteopontin/OPN ELISAs