Mouse RAGE DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.

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We have publications tested in 2 confirmed species: Mouse, Rabbit.

Showing Publications 1 - 8 of 8.

Publications using DY1179	Applications	Species
A Kindermann, L Binder, J Baier, B Gündel, A Simm, R Haase, B Bartling Severe but not moderate hyperoxia of newborn mice causes an emphysematous lung phenotype in adulthood without persisting oxidative stress and inflammation BMC Pulm Med, 2019-12-16;19(1):245. 2019-12-16 [PMID: 31842840] (Mouse)		Mouse
Kagedan D, Lecker I, Batruch I Characterization of the seminal plasma proteome in men with prostatitis by mass spectrometry. Clin Proteomics, 2012-02-06;9(1):2. 2012-02-06 [PMID: 22309592] (Rabbit)		Rabbit
Mallidis C, Czerwiec A, Filippi S, O'Neill J, Maggi M, McClure N Spermatogenic and sperm quality differences in an experimental model of metabolic syndrome and hypogonadal hypogonadism. Reproduction, 2011-04-04;142(1):63-71. 2011-04-04 [PMID: 21464116] (Rabbit)		Rabbit
Lee JS, Su X, Rackley C, Matthay MA, Gupta N Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury. Anat Rec (Hoboken), 2010-11-16;294(1):165-72. 2010-11-16 [PMID: 21157927] (Mouse)		Mouse
van Zoelen MA, Achouiti A, Schmidt AM, Yang H, Florquin S, Tracey KJ, van der Poll T Ligands of the receptor for advanced glycation end products, including high-mobility group box 1, limit bacterial dissemination during Escherichia coli peritonitis. Crit. Care Med., 2010-06-01;38(6):1414-22. 2010-06-01 [PMID: 20386310] (Mouse)		Mouse
Kuhla A, Hettwer C, Menger MD Oxidative stress-associated rise of hepatic protein glycation increases inflammatory liver injury in uncoupling protein-2 deficient mice. Lab. Invest., 2010-04-05;90(8):1189-98. 2010-04-05 [PMID: 20368701] (Mouse)		Mouse
Tan AL, Sourris KC, Harcourt BE, Thallas-Bonke V, Penfold S, Andrikopoulos S, Thomas MC, O'Brien RC, Bierhaus A, Cooper ME, Forbes JM, Coughlan MT Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy. Am. J. Physiol. Renal Physiol., 2009-12-16;298(3):F763-70. 2009-12-16 [PMID: 20015941] (Mouse)		Mouse
Dave SH, Tilstra JS, Matsuoka K, Li F, DeMarco RA, Beer-Stolz D, Sepulveda AR, Fink MP, Lotze MT, Plevy SE Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. J. Leukoc. Biol., 2009-05-19;86(3):633-43. 2009-05-19 [PMID: 19454652] (Mouse)		Mouse

Array DY1179

• AGER Antibodies
• AGER ELISA Kit
• AGER Lysate
• AGER Proteins
• AGER ELISAs
• AGER Proteins and Enzymes