Mouse PD-L1/B7-H1 DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. PD-L1 binds to T cell B7-1/CD80 and PD-1. It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells. It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development. PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells. In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 3 of 3.

Publications using DY1019-05	Applications	Species
Sun, H;Zhang, Y;Wang, J;Su, J;Zhou, D;Yu, X;Xu, Y;Yang, W; Application of Lung-Targeted Lipid Nanoparticle-delivered mRNA of soluble PD-L1 via SORT Technology in Acute Respiratory Distress Syndrome Theranostics 2023-09-04 [PMID: 37771784] (Mouse)		Mouse
X Gao, W Li, F Syed, F Yuan, P Li, Q Yu PD-L1 signaling in reactive astrocytes counteracts neuroinflammation and ameliorates neuronal damage after traumatic brain injury Journal of Neuroinflammation, 2022-02-08;19(1):43. 2022-02-08 [PMID: 35135580] (Mouse)		Mouse
NV Bogatcheva, ME Coleman Concentrated Secretome of Adipose Stromal Cells Limits Influenza A Virus-Induced Lung Injury in Mice Cells, 2021-03-24;10(4):. 2021-03-24 [PMID: 33804896] (Mouse)		Mouse

Array DY1019-05

• PD-L1 Antibodies
• PD-L1 Antibody Pairs
• PD-L1 ELISA Kit
• PD-L1 Lysate
• PD-L1 Proteins
• PD-L1 Proteins and Enzymes
• PD-L1 ELISAs