Mouse LIF Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Based on its helical structure, LIF (Leukemia Inhibitory Factor) is considered a member of the Interleukin-6 family of cytokines. Functionally, it has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. Some cell types known to express LIF include activated T cells, monocytes, astrocytes, osteoblasts, keratinocytes, regenerating skeletal muscle, mast cells, and fibroblasts. The activities of LIF are mediated through a high-affinity heterodimeric receptor complex consisting of two membrane glycoproteins: an alpha subunit (LIF R alpha, also known as LIF R beta and CD118) that binds LIF with low affinity and the 130 kDa (gp130) subunit that does not bind LIF by itself, but is required for high-affinity binding of LIF by the complex.

We have publications tested in 3 confirmed species: Mouse, Bovine, Transgenic Mouse.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using MLF00	Applications	Species
Kwon, YY;Hui, S; IL-6 is dispensable for causing cachexia in the colon carcinoma 26 model bioRxiv : the preprint server for biology 2023-05-02 [PMID: 37205425] (Mouse)		Mouse
S Xu, X Yang, Q Chen, Z Liu, Y Chen, X Yao, A Xiao, J Tian, L Xie, M Zhou, Z Hu, F Zhu, X Xu, F Hou, J Nie Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis EBioMedicine, 2022-11-04;86(0):104312. 2022-11-04 [PMID: 36335669] (Mouse)		Mouse
P Li, Q Li, N Biswas, H Xin, T Diemer, L Liu, L Perez Guti, G Paternostr, C Piermarocc, S Domanskyi, RK Wang, N Ferrara LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy Embo Molecular Medicine, 2021-11-15;0(0):e14511. 2021-11-15 [PMID: 34779136] (Bovine, Mouse)		Bovine, Mouse
JW Lee, J Hur, YW Kwon, CW Chae, JI Choi, I Hwang, JY Yun, JA Kang, YE Choi, YH Kim, SE Lee, C Lee, DH Jo, H Seok, BS Cho, SH Baek, HS Kim KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state Journal of hematology & oncology, 2021-09-16;14(1):148. 2021-09-16 [PMID: 34530889] (Mouse)		Mouse
J Wang, GR Sareddy, Y Lu, UP Pratap, F Tang, KM Greene, PL Meyre, RR Tekmal, RK Vadlamudi, DW Brann Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective Following Ischemic Brain Injury J Neurosci, 2020-11-06;0(0):. 2020-11-06 [PMID: 33158962] (Mouse)		Mouse
SS Welc, I Flores, M Wehling-He, J Ramos, Y Wang, C Bertoni, JG Tidball Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy Nat Commun, 2019-06-26;10(1):2788. 2019-06-26 [PMID: 31243277] (Mouse, Transgenic Mouse)		Mouse, Transgenic Mouse
M Shoji, H Minato, S Ogaki, M Seki, Y Suzuki, S Kume, T Kuzuhara Different murine-derived feeder cells alter the definitive endoderm differentiation of human induced pluripotent stem cells PLoS ONE, 2018-07-26;13(7):e0201239. 2018-07-26 [PMID: 30048506] (Mouse)		Mouse
Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction PLoS ONE, 2016-05-26;11(5):e0156562. 2016-05-26 [PMID: 27227407] (Mouse)		Mouse
Wu L, Ong S, Talor M, Barin J, Baldeviano G, Kass D, Bedja D, Zhang H, Sheikh A, Margolick J, Iwakura Y, Rose N, Cihakova D Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy. J Exp Med, 2014-06-16;211(7):1449-64. 2014-06-16 [PMID: 24935258] (Mouse)		Mouse
Yeo D, Kiparissides A, Cha J, Aguilar-Gallardo C, Polak J, Tsiridis E, Pistikopoulos E, Mantalaris A Improving embryonic stem cell expansion through the combination of perfusion and Bioprocess model design. PLoS ONE, 2013-12-10;8(12):e81728. 2013-12-10 [PMID: 24339957] (Mouse)		Mouse
Quinton LJ, Mizgerd JP, Hilliard KL Leukemia inhibitory factor signaling is required for lung protection during pneumonia. J. Immunol., 2012-05-11;188(12):6300-8. 2012-05-11 [PMID: 22581855] (Mouse)		Mouse
White CA, Zhang JG, Salamonsen LA, Baca M, Fairlie WD, Metcalf D, Nicola NA, Robb L, Dimitriadis E Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: a nonhormonal contraceptive strategy. Proc. Natl. Acad. Sci. U.S.A., 2007-11-27;104(49):19357-62. 2007-11-27 [PMID: 18042698] (Mouse)		Mouse
Ishibashi T, Dakin KA, Stevens B, Lee PR, Kozlov SV, Stewart CL, Fields RD Astrocytes promote myelination in response to electrical impulses. Neuron, 2006-03-16;49(6):823-32. 2006-03-16 [PMID: 16543131] (Mouse)		Mouse
Metcalfe SM, Watson TJ, Shurey S, Adams E, Green CJ Leukemia inhibitory factor is linked to regulatory transplantation tolerance. Transplantation, 2005-03-27;79(6):726-30. 2005-03-27 [PMID: 15785381] (Mouse)		Mouse
Metcalfe SM, Muthukumarana PA, Thompson HL, Haendel MA, Lyons GE Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance. FEBS Lett., 2005-01-31;579(3):609-14. 2005-01-31 [PMID: 15670816] (Mouse)		Mouse
Show All 15 Publications. Collapse Publications.

Array MLF00

• LIF Antibodies
• LIF ELISA Kits
• LIF Lysate
• LIF Proteins
• LIF ELISAs
• LIF Proteins and Enzymes