Mouse LIF DuoSet

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Based on its helical structure, LIF (Leukemia Inhibitory Factor) is considered a member of the Interleukin-6 family of cytokines. Functionally, it has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. Some cell types known to express LIF include activated T cells, monocytes, astrocytes, osteoblasts, keratinocytes, regenerating skeletal muscle, mast cells, and fibroblasts. The activities of LIF are mediated through a high-affinity heterodimeric receptor complex consisting of two membrane glycoproteins: an alpha subunit (LIF R alpha, also known as LIF R beta and CD118) that binds LIF with low affinity and the 130 kDa (gp130) subunit that does not bind LIF by itself, but is required for high-affinity binding of LIF by the complex.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 5 of 5.

Publications using DY449	Applications	Species
Yang, X;Wang, J;Chang, CY;Zhou, F;Liu, J;Xu, H;Ibrahim, M;Gomez, M;Guo, GL;Liu, H;Zong, WX;Wondisford, FE;Su, X;White, E;Feng, Z;Hu, W; Leukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia in mice Nature communications 2024-01-20 [PMID: 38245529] (Mouse)		Mouse
Barisas, DAG;Kabir, AU;Wu, J;Krchma, K;Kim, M;Subramanian, M;Zinselmeyer, BH;Stewart, CL;Choi, K; Tumor-derived interleukin-1? and leukemia inhibitory factor promote extramedullary hematopoiesis PLoS biology 2023-05-01 [PMID: 37134077]
B Khaleel, E Lunenfeld, J Kapelushni, M Huleihel Effect of Chemotherapy Cytarabine and Acute Myeloid Leukemia on the Development of Spermatogenesis at the Adult Age of Immature Treated Mice International Journal of Molecular Sciences, 2022-04-04;23(7):. 2022-04-04 [PMID: 35409373] (Human)		Human
CL Sanchez, SG Sims, JD Nowery, GP Meares Endoplasmic reticulum stress differentially modulates the IL-6 family of cytokines in murine astrocytes and macrophages Sci Rep, 2019-10-17;9(1):14931. 2019-10-17 [PMID: 31624329] (Mouse)		Mouse
H Huang, Y Zhang, V Gallegos, N Sorrelle, MM Zaid, J Toombs, W Du, S Wright, M Hagopian, Z Wang, AN Hosein, AA Sathe, C Xing, EJ Koay, KE Driscoll, RA Brekken Targeting TGFbetaR2-mutant tumors exposes vulnerabilities to stromal TGFbeta blockade in pancreatic cancer EMBO Mol Med, 2019-10-14;0(0):e10515. 2019-10-14 [PMID: 31609088] (Mouse)		Mouse

Array DY449

• LIF Antibodies
• LIF ELISA Kits
• LIF Lysate
• LIF Proteins
• LIF ELISAs
• LIF Proteins and Enzymes