Mouse G-CSF Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Mouse granulocyte-colony stimulating factor (G-CSF) is a 24-25 kDa monomeric glycoprotein that regulates the proliferation, differentiation and activation of hematopoietic cells. Mouse G-CSF cDNA encodes a 208 amino acid (aa) precursor protein with a 30 aa signal sequence that is proteolytically cleaved to form a 178 aa O-glycosylated mature protein containing two intrachain disulfide bridges. In humans, two distinct cDNA clones, encoding a 204 aa form and a minor alternatively spliced 207 aa form of G-CSF precursors, have been isolated. Mouse and human G-CSF are 76% identical at the aa sequence level and the two proteins show species cross-reactivity. G-CSF is produced primarily by monocytes and macrophages upon activation by endotoxin, TNF-alpha or IL-1. Other cell types, including fibroblasts, endothelial cells, astrocytes and bone marrow stroma cells, can also secrete G-CSF after activation. In addition, various tumor cells express G-CSF constitutively.  

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 10 of 51. Show All 51 Publications. Collapse Publications.

Publications using MCS00	Applications	Species
Achlaug, L;Awwad, L;Langier Goncalves, I;Goldenberg, T;Aronheim, A; Tumor Growth Ameliorates Cardiac Dysfunction and Suppresses Fibrosis in a Mouse Model for Duchenne Muscular Dystrophy International journal of molecular sciences 2023-08-09 [PMID: 37628775] (Mouse)		Mouse
D Zhang, X Gao, H Li, DK Borger, Q Wei, E Yang, C Xu, S Pinho, PS Frenette The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow Cell Stem Cell, 2022-01-21;0(0):. 2022-01-21 [PMID: 35065706] (Mouse)		Mouse
AM La Rose, V Bazioti, JA Hoogerland, AF Svendsen, AG Groenen, M van Faasse, MGS Rutten, NJ Kloosterhu, B Dethmers-A, JH Nijland, G Mithieux, F Rajas, F Kuipers, MV Lukens, O Soehnlein, MH Oosterveer, M Westerterp Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia Molecular Metabolism, 2021-06-04;53(0):101265. 2021-06-04 [PMID: 34091064] (Mouse)		Mouse
AA Hastreiter, GG Dos Santos, EN Makiyama, EWC Santos, P Borelli, RA Fock Effects of protein malnutrition on haematopoietic regulatory activity of bone marrow mesenchymal stem cells The Journal of nutritional biochemistry, 2021-03-08;0(0):108626. 2021-03-08 [PMID: 33705953] (Mouse)		Mouse
WC Chou, Z Guo, H Guo, L Chen, G Zhang, K Liang, L Xie, X Tan, SA Gibson, E Rampanelli, Y Wang, SA Montgomery, WJ Brickey, M Deng, L Freeman, S Zhang, MA Su, X Chen, YY Wan, JP Ting AIM2 in regulatory T cells restrains autoimmune diseases Nature, 2021-01-27;0(0):. 2021-01-27 [PMID: 33505023] (Mouse)		Mouse
M Kist, LG K?m?ves, T Goncharov, DL Dugger, C Yu, M Roose-Girm, K Newton, JD Webster, D Vucic Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death Cell Death Differ, 2020-09-30;0(0):. 2020-09-30 [PMID: 32999468] (Mouse)		Mouse
Y Itatani, T Yamamoto, C Zhong, AA Molinolo, J Ruppel, P Hegde, MM Taketo, N Ferrara Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer Proc. Natl. Acad. Sci. U.S.A., 2020-08-19;0(0):. 2020-08-19 [PMID: 32817421] (Mouse)		Mouse
M Bosiljcic, RA Cederberg, MJ Hamilton, NE LePard, BT Harbourne, JL Collier, EC Halvorsen, R Shi, SE Franks, AY Kim, JP Banáth, M Hamer, FM Rossi, KL Bennewith Targeting myeloid-derived suppressor cells in combination with primary mammary tumor resection reduces metastatic growth in the lungs Breast Cancer Res., 2019-09-05;21(1):103. 2019-09-05 [PMID: 31488209] (Mouse)		Mouse
Z Li, J Hardij, SS Evers, CR Hutch, SM Choi, Y Shao, BS Learman, KT Lewis, RL Schill, H Mori, DP Bagchi, SM Romanelli, KS Kim, E Bowers, C Griffin, RJ Seeley, K Singer, DA Sandoval, CJ Rosen, OA MacDougald G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche J. Clin. Invest., 2019-05-06;129(6):2404-2416. 2019-05-06 [PMID: 31063988] (Mouse)		Mouse
FH Brennan, T Jogia, ER Gillespie, LV Blomster, XX Li, B Nowlan, GM Williams, E Jacobson, GW Osborne, FA Meunier, SM Taylor, KE Campbell, KP MacDonald, JP Levesque, TM Woodruff, MJ Ruitenberg Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2 JCI Insight, 2019-05-02;4(9):. 2019-05-02 [PMID: 31045582] (Mouse)		Mouse
JM Ubellacker, N Baryawno, N Severe, MJ DeCristo, J Sceneay, JN Hutchinson, MT Haider, CS Rhee, Y Qin, WM Gregory, AC Garrido-Ca, I Holen, JE Brown, RE Coleman, DT Scadden, SS McAllister Modulating bone marrow hematopoietic lineage potential to prevent bone metastasis in breast cancer Cancer Res., 2018-07-31;0(0):. 2018-07-31 [PMID: 30065048] (Mouse)		Mouse
M Mastri, CR Lee, A Tracz, RS Kerbel, M Dolan, Y Shi, JML Ebos Tumor-independent host secretomes induced by angiogenesis and immune-checkpoint inhibitors Mol. Cancer Ther., 2018-04-25;0(0):. 2018-04-25 [PMID: 29695634] (Mouse)		Mouse
N Guo, V DeAngelis, C Zhu, EH Schuchman, CM Simonaro Pentosan Polysulfate Treatment of Mucopolysaccharidosis Type IIIA Mice JIMD Rep, 2018-04-14;0(0):. 2018-04-14 [PMID: 29654542] (Mouse)		Mouse
MC Okondo, SD Rao, CY Taabazuing, AJ Chui, SE Poplawski, DC Johnson, DA Bachovchin Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome Cell Chem Biol, 2018-01-27;0(0):. 2018-01-27 [PMID: 29396289] (Mouse)		Mouse
CJ Kurkjian, H Guo, ND Montgomery, N Cheng, H Yuan, JR Merrill, GD Sempowski, WJ Brickey, JP Ting The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome Sci Rep, 2017-12-11;7(1):17355. 2017-12-11 [PMID: 29230065] (Mouse)		Mouse
TS Kapellos, C Recio, DR Greaves, AJ Iqbal Cannabinoid Receptor 2 Modulates Neutrophil Recruitment in a Murine Model of Endotoxemia Mediators Inflamm., 2017-08-09;2017(0):4315412. 2017-08-09 [PMID: 28852269] (Mouse)		Mouse
W Lu, D Jia, S An, M Mu, X Qiao, Y Liu, X Li, D Wang Calf Spleen Extractive Injection protects mice against cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 signaling Sci Rep, 2017-08-21;7(1):8402. 2017-08-21 [PMID: 28827748] (Mouse)		Mouse
M Takehara, S Seike, T Takagishi, K Kobayashi, M Nagahama Peptidoglycan accelerates granulopoiesis through a TLR2- and MyD88-dependent pathway Biochem. Biophys. Res. Commun., 2017-04-15;487(2):419-425. 2017-04-15 [PMID: 28419838] (Mouse)		Mouse
Limo Chen Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression Oncoimmunology, 2016-09-26;5(11):e1234570. 2016-09-26 [PMID: 27999749] (Mouse)		Mouse
Key role for neutrophils in radiation-induced antitumor immune responses: Potentiation with G-CSF Proc Natl Acad Sci USA, 2016-09-20;0(0):. 2016-09-20 [PMID: 27651484] (Mouse)		Mouse
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity Cell, 2016-08-11;0(0):. 2016-08-11 [PMID: 27523608] (Mouse)		Mouse
Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines Stem Cell Reports, 2016-05-12;0(0):. 2016-05-12 [PMID: 27185281] (Mouse)		Mouse
A Spiegel, MW Brooks, S Houshyar, F Reinhardt, M Ardolino, E Fessler, MB Chen, JA Krall, J DeCock, IK Zervantona, A Iannello, Y Iwamoto, V Cortez-Ret, RD Kamm, MJ Pittet, DH Raulet, RA Weinberg Neutrophils suppress intraluminal NK-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells Cancer Discov, 2016-04-12;0(0):. 2016-04-12 [PMID: 27072748] (Mouse)		Mouse
Chang S, Li H, Huang Y, Tasi W, Chou Y, Lu S SB203580 increases G-CSF production via a stem-loop destabilizing element in the 3' untranslated region in macrophages independently of its effect on p38 MAPK activity. J Biomed Sci, 2016-01-16;23(1):3. 2016-01-16 [PMID: 26772539] (Mouse)		Mouse
Mathews J, Kasahara D, Ribeiro L, Wurmbrand A, Ninin F, Shore S gammadelta T Cells Are Required for M2 Macrophage Polarization and Resolution of Ozone-Induced Pulmonary Inflammation in Mice. PLoS ONE, 2015-07-02;10(7):e0131236. 2015-07-02 [PMID: 26135595] (Mouse)		Mouse
Chang S, Lin S, Yang H, Chou Y, Gao J, Lu S LPS-Induced G-CSF Expression in Macrophages Is Mediated by ERK2, but Not ERK1. PLoS ONE, 2015-06-26;10(6):e0129685. 2015-06-26 [PMID: 26114754] (Mouse)		Mouse
Iyer S, Brooks R, Gumbleton M, Kerr W SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging. Stem Cells Dev, 2015-02-05;24(9):1073-81. 2015-02-05 [PMID: 25525673] (Mouse)		Mouse
Brooks R, Iyer S, Akada H, Neelam S, Russo C, Chisholm J, Kerr W Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi. Stem Cells, 2015-03-01;33(3):848-58. 2015-03-01 [PMID: 25402778] (Mouse)		Mouse
Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz M Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood, 2014-07-02;124(9):1393-403. 2014-07-02 [PMID: 24990886] (Mouse)		Mouse
Wu L, Ong S, Talor M, Barin J, Baldeviano G, Kass D, Bedja D, Zhang H, Sheikh A, Margolick J, Iwakura Y, Rose N, Cihakova D Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy. J Exp Med, 2014-06-16;211(7):1449-64. 2014-06-16 [PMID: 24935258] (Mouse)		Mouse
Liu Q, Tan Q, Zheng Y, Chen K, Qian C, Li N, Wang Q, Cao X Blockade of Fas signaling in breast cancer cells suppresses tumor growth and metastasis via disruption of Fas signaling-initiated cancer-related inflammation. J Biol Chem, 2014-03-13;289(16):11522-35. 2014-03-13 [PMID: 24627480] (Mouse)		Mouse
Jiao , Jingjing, Dragomir , Ana-Cris, Kocabayoglu , Peri, Rahman , Adeeb H, Chow , Andrew, Hashimoto , Daigo, Leboeuf , Marylene, Kraus , Thomas, Moran , Thomas, Carrasco-Avino , Gonzalo, Friedman , Scott L, Merad , Miriam, Aloman , Costica Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils. J Immunol, 2014-03-03;192(7):3374-82. 2014-03-03 [PMID: 24591364] (Mouse)		Mouse
Grover , Amit, Mancini , Elena, Moore , Susan, Mead , Adam J, Atkinson , Deborah, Rasmussen , Kasper D, O'Carroll , Donal, Jacobsen , Sten Eir, Nerlov , Claus Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate. J Exp Med, 2014-02-03;211(2):181-8. 2014-02-03 [PMID: 24493804] (Mouse)		Mouse
Cunha M, Lima F, Vinolo M, Hastreiter A, Curi R, Borelli P, Fock R Protein malnutrition induces bone marrow mesenchymal stem cells commitment to adipogenic differentiation leading to hematopoietic failure. PLoS ONE, 2013-03-14;8(3):e58872. 2013-03-14 [PMID: 23516566] (Mouse)		Mouse
Bugl S, Wirths S, Radsak M, Schild H, Stein P, Andre M, Muller M, Malenke E, Wiesner T, Marklin M, Frick J, Handgretinger R, Rammensee H, Kanz L, Kopp H Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood, 2012-12-05;121(5):723-33. 2012-12-05 [PMID: 23223360] (Mouse)		Mouse
Beier , Fabian, Foronda , Miguel, Martinez , Paula, Blasco , Maria A Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita. Blood, 2012-08-29;120(15):2990-3000. 2012-08-29 [PMID: 22932806] (Mouse)		Mouse
Waight JD, Hu Q, Miller A, Liu S, Abrams SI Tumor-derived G-CSF facilitates neoplastic growth through a granulocytic myeloid-derived suppressor cell-dependent mechanism. PLoS ONE, 2011-11-16;6(11):e27690. 2011-11-16 [PMID: 22110722] (Mouse)		Mouse
Kaplan IM, Morisot S, Heiser D, Cheng WC, Kim MJ, Civin CI Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence. J. Immunol., 2011-01-26;186(5):2826-34. 2011-01-26 [PMID: 21270394] (Mouse)		Mouse
Kreisel D, Sugimoto S, Tietjens J, Zhu J, Yamamoto S, Krupnick AS, Carmody RJ, Gelman AE Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis. J. Clin. Invest., 2010-12-13;121(1):265-76. 2010-12-13 [PMID: 21157041] (Mouse)		Mouse
McDermott DH, De Ravin SS, Jun HS Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis. Blood, 2010-07-08;116(15):2793-802. 2010-07-08 [PMID: 20616219] (Mouse)		Mouse
Shaked Y, Henke E, Roodhart JM, Mancuso P, Langenberg MH, Colleoni M, Daenen LG, Man S, Xu P, Emmenegger U, Tang T, Zhu Z, Witte L, Strieter RM, Bertolini F, Voest EE, Benezra R, Kerbel RS Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell, 2008-09-09;14(3):263-73. 2008-09-09 [PMID: 18772115] (Mouse)		Mouse
Gomez JC, Soltys J, Okano K, Dinauer MC, Doerschuk CM The role of Rac2 in regulating neutrophil production in the bone marrow and circulating neutrophil counts. Am. J. Pathol., 2008-06-26;173(2):507-17. 2008-06-26 [PMID: 18583316] (Mouse)		Mouse
Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc. Natl. Acad. Sci. U.S.A., 2007-10-17;104(43):17069-74. 2007-10-17 [PMID: 17942672] (Mouse)		Mouse
Gregory AD, Hogue LA, Ferkol TW, Link DC Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection. Blood, 2006-12-21;109(8):3235-43. 2006-12-21 [PMID: 17185469] (Mouse)		Mouse
Kim SY, Nguyen AD, Gao JL, Murphy PM, Mansfield BC, Chou JY Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions. J. Biol. Chem., 2006-08-04;281(39):28794-801. 2006-08-04 [PMID: 16891306] (Mouse)		Mouse
Wang CH, Verma S, Hsieh IC, Chen YJ, Kuo LT, Yang NI, Wang SY, Wu MY, Hsu CM, Cheng CW, Cherng WJ Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system. J. Mol. Cell. Cardiol., 2006-05-05;41(1):34-43. 2006-05-05 [PMID: 16678199] (Mouse)		Mouse
Liao HF, Chen YJ, Yang YC A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression. Life Sci., 2005-02-25;77(4):400-13. 2005-02-25 [PMID: 15894009] (Mouse)		Mouse
Gamelli R, He LK, Hahn E Granulocyte colony-stimulating factor: release is not impaired after burn wound infection. J Trauma, 2002-08-01;53(2):284-9; discus. 2002-08-01 [PMID: 12169935] (Mouse)		Mouse
Blumenthal RD, Reising A, Leon E Modulation of marrow proliferation and chemosensitivity by tumor-produced cytokines from syngeneic pancreatic tumor lines. Clin. Cancer Res., 2002-05-01;8(5):1301-9. 2002-05-01 [PMID: 12006552] (Mouse)		Mouse
Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice. Arch. Dermatol. Res., 2001-11-01;293(10):508-14. 2001-11-01 [PMID: 11820727] (Mouse)		Mouse
Show All 51 Publications. Collapse Publications.

Array MCS00

• G-CSF Antibodies
• G-CSF Antibody Pair
• G-CSF ELISA Kit
• G-CSF Lysates
• G-CSF Proteins
• G-CSF ELISAs
• G-CSF Proteins and Enzymes