Mouse 4-1BB/TNFRSF9 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

4-1BB, also known as CD137 and TNFRSF9, is a transmembrane TNF receptor superfamily member that is expressed as on various populations of activated T cell including CD4+, CD8+, memory CD8+, NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. 4-1BB binding by 4-1BB Ligand costimulates T cell proliferation, activation, and/or survival and can enhance the activation-induced cell death of repetitively stimulated T cells. 4-1BB can associate with OX40 on activated T cells, forming a complex that responds to either ligand and inhibits Treg and CD8+ T cell proliferation. Reverse signaling through 4-1BB Ligand inhibits the development of dendritic cells, B cells, and osteoclasts but supports mature dendritic cell survival and costimulates the proliferation and activation of mast cells.

We have publications tested in 1 confirmed species: Mouse.

Showing Publications 1 - 2 of 2.

Publications using DY937	Applications	Species
MH Forsberg, B Foda, DV Serreze, YG Chen Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus Sci Rep, 2019-03-13;9(1):4316. 2019-03-13 [PMID: 30867509] (Mouse)		Mouse
Kachapati , Kritika, Adams , David E, Wu , Yuehong, Steward , Charles, Rainbow , Daniel B, Wicker , Linda S, Mittler , Robert S, Ridgway , William The B10 Idd9.3 Locus Mediates Accumulation of Functionally Superior CD137+ Regulatory T Cells in the Nonobese Diabetic Type 1 Diabetes Model. J Immunol, 2012-10-12;189(10):5001-15. 2012-10-12 [PMID: 23066155] (Mouse)		Mouse

Array DY937

• 4-1BB/TNFRSF9/CD137 Antibodies
• 4-1BB/TNFRSF9/CD137 ELISA Kit
• 4-1BB/TNFRSF9/CD137 Proteins
• 4-1BB/TNFRSF9/CD137 ELISAs
• 4-1BB/TNFRSF9/CD137 Proteins and Enzymes