MMP-2 Antibody (36006) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-2 (gelatinase A), a type IV collagenase, can degrade a broad range of substrates including type IV, V, VII and X collagens as well as elastin and fibronectin. It is believed to act synergistically with interstitial collagenase (MMP-1) in the degradation of fibrillar collagens as it degrades their denatured gelatin forms. MMP-2 has been shown to be associated with many connective tissue cells as well as neutrophils, macrophages and monocytes. Structurally, MMP-2 may be divided into several distinct domains: a pro-domain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a fibronectin-like domain thought to play a role in substrate targeting;and a carboxyl terminal (hemopexin-like) domain containing 2 N-linked glycosylation sites.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 7 applications: Cell-based ELISA, ELISA Development, Flow Cytometry, IHC-Fr, IHC-P, Neutralization, Western Blot.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using MAB902	Applications	Species
Narjes Nasiri Ansari, Flora Spentza, Georgios K. Dimitriadis, Aphrodite Daskalopoulou, Angeliki Karapanagioti, Gerasimos Siasos et al. Orexin-A Exerts Equivocal Role in Atherosclerosis Process Depending on the Duration of Exposure: In Vitro Study Nutrients 12/24/2019 [PMID: 31878149]
MMP-2 Isoforms in Aortic Tissue and Serum of Patients with Ascending Aortic Aneurysms and Aortic Root Aneurysms PLoS ONE, 2016-11-01;11(11):e0164308. 11/1/2016 [PMID: 27802285]
SIN-HYE PARK, MIN JAE SHIN, DAE WON KIM, JINSEU PARK, SOO YOUNG CHOI, YOUNG-HEE KANG Blockade of monocyte-endothelial trafficking by transduced Tat-superoxide dismutase protein International Journal of Molecular Medicine 2/1/2016 [PMID: 26707483]
Elena Kostova, Maja Slaninka-Miceska, Nikola Labacevski, Krume Jakovski, Jasmina Trojachanec, Emilija Atanasovska et al. Expression of matrix metalloproteinases 2, 7 and 9 in patients with colorectal cancer Vojnosanitetski pregled 2/13/2014 [PMID: 24516991]
Li MQ, Hou XF, Shao J, Tang CL, Li DJ The DSCs-expressed CD82 controls the invasiveness of trophoblast cells via integrinbeta1/MAPK/MAPK3/1 signaling pathway in human first-trimester pregnancy. Biol. Reprod., 2010-01-14;82(5):968-79. 2010-01-14 [PMID: 20075392] (Cell-based ELISA, Human)	Cell-based ELISA	Human
Teles RM, Teles RB, Amadeu TP, Moura DF, Mendonca-Lima L, Ferreira H, Santos IM, Nery JA, Sarno EN, Sampaio EP High matrix metalloproteinase production correlates with immune activation and leukocyte migration in leprosy reactional lesions. Infect. Immun., 2009-12-14;78(3):1012-21. 2009-12-14 [PMID: 20008541] (IHC-Fr, Human)	IHC-Fr	Human
Schneider P, Costa O, Legrand E In vitro secretion of matrix metalloprotease 9 is a prognostic marker in childhood acute lymphoblastic leukemia. Leuk. Res., 2009-09-12;34(1):24-31. 2009-09-12 [PMID: 19748669] (Flow Cytometry, Human)	Flow Cytometry	Human
Dagouassat M, Suffee N, Hlawaty H, Haddad O, Charni F, Laguillier C, Vassy R, Martin L, Schischmanoff PO, Gattegno L, Oudar O, Sutton A, Charnaux N Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells. Int. J. Cancer, 2010-03-01;126(5):1095-108. 2010-03-01 [PMID: 19642141] (Neutralization, Human)	Neutralization	Human
Ooi YH, Oh DJ, Rhee DJ Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells. Invest. Ophthalmol. Vis. Sci., 2009-05-14;50(11):5259-65. 2009-05-14 [PMID: 19443729] (Western Blot, Human)	Western Blot	Human
Smith ER, Zurakowski D, Saad A, Scott RM, Moses MA Urinary biomarkers predict brain tumor presence and response to therapy. Clin. Cancer Res., 2008-04-15;14(8):2378-86. 2008-04-15 [PMID: 18413828] (IHC-P, Human)	IHC-P	Human
Struckmann K, Mertz K, Steu S, Storz M, Staller P, Krek W, Schraml P, Moch H pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma. J. Pathol., 2008-03-01;214(4):464-71. 2008-03-01 [PMID: 18189328] (IHC-P, Human)	IHC-P	Human
Borrelli V, di Marzo L, Sapienza P, Colasanti M, Moroni E, Cavallaro A Role of platelet-derived growth factor and transforming growth factor beta1 the in the regulation of metalloproteinase expressions. Surgery, 2006-09-01;140(3):454-63. 2006-09-01 [PMID: 16934609] (Western Blot, Human)	Western Blot	Human
Haug C, Lenz C, Diaz F, Bachem MG Oxidized low-density lipoproteins stimulate extracellular matrix metalloproteinase Inducer (EMMPRIN) release by coronary smooth muscle cells. Arterioscler. Thromb. Vasc. Biol., 2004-08-19;24(10):1823-9. 2004-08-19 [PMID: 15319264] (ELISA Development, Human)	ELISA Development	Human
Show All 13 Publications. Collapse Publications.

Array MAB902

• MMP-2 Antibodies
• MMP-2 ELISA Kits
• MMP-2 Lysate
• MMP-2 Proteins
• MMP-2 ELISAs
• MMP-2 Proteins and Enzymes