MMP-2 Antibody (1A10)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP‑2 (gelatinase A), a type IV collagenase, can degrade a broad range of substrates including type IV, V, VII and X collagens as well as elastin and fibronectin. It is believed to act synergistically with interstitial collagenase (MMP‑1) in the degradation of fibrillar collagens as it degrades their denatured gelatin forms. MMP‑2 has been shown to be associated with many connective tissue cells as well as neutrophils, macrophages and monocytes. Structurally, MMP‑2 may be divided into several distinct domains: a pro-domain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a fibronectin-like domain thought to play a role in substrate targeting; and a carboxyl terminal (hemopexin-like) domain containing 2 N-linked glycosylation sites.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, Western Blot.

Showing Publications 1 - 2 of 2.

Publications using MAB903	Applications	Species
NI Medeiros, RC Fares, EP Franco, GR Sousa, RT Mattos, AT Chaves, MD Nunes, WO Dutra, R Correa-Oli, MO Rocha, JA Gomes Differential Expression of Matrix Metalloproteinases 2, 9 and Cytokines by Neutrophils and Monocytes in the Clinical Forms of Chagas Disease PLoS Negl Trop Dis, 2017-01-24;11(1):e0005284. 2017-01-24 [PMID: 28118356] (Flow Cytometry, Human)	Flow Cytometry	Human
Zhao Z, McCloud B, Fleming R, Klempner MS Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro. Biochem. Biophys. Res. Commun., 2007-05-02;358(2):528-33. 2007-05-02 [PMID: 17485071] (Western Blot, Human)	Western Blot	Human

Array MAB903

• MMP-2 Antibodies
• MMP-2 ELISA Kits
• MMP-2 Lysate
• MMP-2 Proteins
• MMP-2 ELISAs
• MMP-2 Proteins and Enzymes