MMP-2 Antibody (101721)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP‑2 (gelatinase A), a type IV collagenase, can degrade a broad range of substrates including type IV, V, VII and X collagens as well as elastin and fibronectin. It is believed to act synergistically with interstitial collagenase (MMP‑1) in the degradation of fibrillar collagens as it degrades their denatured gelatin forms. MMP‑2 has been shown to be associated with many connective tissue cells as well as neutrophils, macrophages and monocytes. Structurally, MMP‑2 may be divided into several distinct domains: a pro-domain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a fibronectin-like domain thought to play a role in substrate targeting; and a carboxyl terminal (hemopexin-like) domain containing 2 N-linked glycosylation sites.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 3 of 3.

Publications using MAB9021	Applications	Species
J Kudelski, A Tokarzewic, M Gudowska-S, B Mroczko, P Ch?osta, M Bruczko-Go, P Mitura, G M?ynarczyk The Significance of Matrix Metalloproteinase 9 (MMP-9) and Metalloproteinase 2 (MMP-2) in Urinary Bladder Cancer Biomedicines, 2023-03-20;11(3):. 2023-03-20 [PMID: 36979935] (Western Blot, Human)	Western Blot	Human
GB Kim, JM Lee, DL Nguyen, J Lee, YP Kim Activatable Peptides for Rapid and Simple Visualization of Protease Activity Secreted in Living Cells International Journal of Molecular Sciences, 2022-01-30;23(3):. 2022-01-30 [PMID: 35163529] (Western Blot, Human)	Western Blot	Human
Caruso R, Fina D, Peluso I, Fantini MC, Tosti C, Del Vecchio Blanco G, Paoluzi OA, Caprioli F, Andrei F, Stolfi C, Romano M, Ricci V, MacDonald TT, Pallone F, Monteleone G IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J. Immunol., 2007-05-01;178(9):5957-65. 2007-05-01 [PMID: 17442980] (Western Blot, Human)	Western Blot	Human

Array MAB9021

• MMP-2 Antibodies
• MMP-2 ELISA Kits
• MMP-2 Lysate
• MMP-2 Proteins
• MMP-2 ELISAs
• MMP-2 Proteins and Enzymes