MEK1/2 [p Ser218, p Ser222, p Ser226, p Ser222, p Ser226] Antibody (1020E) [Unconjugated] Summary
Additional Information |
Recombinant Monoclonal Antibody. |
Immunogen |
Phosphopeptide containing the human, mouse, and rat MEK1 S218/S222 site |
Modification |
p Ser222, p Ser226, p Ser218, p Ser222, p Ser226 |
Specificity |
Detects human, mouse, and rat MEK1 and MEK2 dually phosphorylated at S218/S222 and S222/S226, respectively. |
Source |
N/A |
Isotype |
IgG |
Clonality |
Monoclonal |
Host |
Rabbit |
Gene |
MAP2K1 |
Purity Statement |
Protein A or G purified from cell culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Packaging, Storage & Formulations
Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
|
Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Preservative |
Sodium Azide |
Reconstitution Instructions |
Reconstitute at 0.5 mg/mL in sterile PBS |
Notes
* Contains <0.1% Sodium Azide, which is not hazardous at this concentration according to GHS classifications. Refer to SDS for additional information and handling instructions.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for MEK1/2 [p Ser218, p Ser222, p Ser226, p Ser222, p Ser226] Antibody (1020E) [Unconjugated]
Background
MEK1 and MEK2, also known as MAP2K1 and MAP2K2, are activated in response to mitogenic stimuli. Activation occurs through dual phosphorylation at S218/S222 of MEK1 and S222/S226 of MEK2 by several upstream MAP3Ks, including the Raf kinases. Both MEK1 and MEK2 are dual-specificity protein kinases, phosphorylating and activating ERK1 and ERK2 at Thr and Tyr positions.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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