MCPIP1/ZC3H12A Antibody (604421) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human MCP-induced protein (MCPIP), also known as ZC3H12A, is an approximately 66 kDa intracellular protein that contains one RNAse domain (aa 134-290), one zinc finger (aa 301-324), and a proline-rich region (aa 458-536). Within aa 426-599, human MCPIP shares approximately 79% aa sequence identity with mouse and rat MCPIP. Its expression is induced by inflammatory stimulation and cellular stress. It acts to dampen inflammatory responses by promoting the degradation of proinflammatory cytokine mRNAs, inhibiting NFkB activation, and antagonizing TLR signaling. MCPIP exhibits deubiquitinase activity and inhibits the biogenesis of miRNA. It also enhances inflammation-induced angiogenesis, osteocyte and adipocyte differentiation, and the cell death of cardiac myocytes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: Immunoprecipitation, Western Blot.

Showing Publications 1 - 8 of 8.

Publications using MAB7875	Applications	Species
G Behrens, SL Edelmann, T Raj, N Kronbeck, T Monecke, E Davydova, EH Wong, L Kifinger, F Giesert, ME Kirmaier, C Hohn, LS de Jonge, MG Pisfil, M Fu, S Theurich, S Feske, N Kawakami, W Wurst, D Niessing, V Heissmeyer Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses Nature Immunology, 2021-11-22;0(0):. 2021-11-22 [PMID: 34811541] (Immunoprecipitation, Human)	Immunoprecipitation	Human
DD Li, R Bechara, K Ramani, CV Jawale, Y Li, JK Kolls, SL Gaffen, PS Biswas RTEC-intrinsic IL-17-driven inflammatory circuit amplifies antibody-induced glomerulonephritis and is constrained by Regnase-1 JCI Insight, 2021-07-08;6(13):. 2021-07-08 [PMID: 34236049] (Western Blot, Human)	Western Blot	Human
Kariana E. Rios, Anuj K. Kashyap, Sean K. Maynard, Michael Washington, Suman Paul, Brian C. Schaefer CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-kappa B activation after TCR engagement. Cellular Immunology 2020-10-01 [PMID: 32763502]
T Gehring, T Erdmann, M Rahm, C Gra beta , A Flatley, TJ O'Neill, S Woods, I Meininger, O Karayel, K Kutzner, M Grau, H Shinohara, K Lammens, R Feederle, SM Hauck, G Lenz, D Krappmann MALT1 Phosphorylation Controls Activation of T Lymphocytes and Survival of ABC-DLBCL Tumor Cells Cell Rep, 2019-10-22;29(4):873-888.e10. 2019-10-22 [PMID: 31644910] (Western Blot, Human)	Western Blot	Human
M Rosenbaum, A Gewies, K Pechloff, C Heuser, T Engleitner, T Gehring, L Hartjes, S Krebs, D Krappmann, M Kriegsmann, W Weichert, R Rad, C Kurts, J Ruland Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells Nat Commun, 2019-05-28;10(1):2352. 2019-05-28 [PMID: 31138793] (Western Blot, Mouse)	Western Blot	Mouse
K Seno, Y Munakata, M Sano, R Kawahara-M, H Takahashi, A Ohkuchi, H Iwata, T Kuwayama, K Shirasuna Aggregation of Human Trophoblast Cells into Three-Dimensional Culture System Enhances Anti-Inflammatory Characteristics through Cytoskeleton Regulation Int J Mol Sci, 2018-08-08;19(8):. 2018-08-08 [PMID: 30096769] (Western Blot, Human)	Western Blot	Human
M Baens, R Stirparo, Y Lampi, D Verbeke, R Vandepoel, J Cools, P Marynen, CE de Bock, S Bornschein Malt1 self-cleavage is critical for regulatory T cell homeostasis and anti-tumor immunity in mice Eur. J. Immunol., 2018-08-07;0(0):. 2018-08-07 [PMID: 30025160] (Western Blot, Mouse)	Western Blot	Mouse
CH Wu, YH Yang, MR Chen, CH Tsai, AL Cheng, SL Doong Autocleavage of the paracaspase MALT1 at Arg-781 attenuates NF-?B signaling and regulates the growth of activated B-cell like diffuse large B-cell lymphoma cells PLoS ONE, 2018-06-28;13(6):e0199779. 2018-06-28 [PMID: 29953499] (Western Blot, Human)	Western Blot	Human

Array MAB7875

• MCPIP1/ZC3H12A Antibodies
• MCPIP1/ZC3H12A Lysate
• MCPIP1/ZC3H12A Proteins