Western Blot: LSP1 Antibody [NBP1-74048] - Western blot analysis of LSP1 in Ramos (1) and Daudi (2) cell lysates.
Immunohistochemistry-Paraffin: LSP1 Antibody [NBP1-74048] - IHC analysis of LSP1 in mouse colon tissue. Abundant membrane staining is visible in the epithelial cells.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified
Alternate Names for LSP1 Antibody - BSA Free
47 kDa actin binding protein
47 kDa actin-binding protein
52 kDa phosphoprotein
F-actin binding and cytoskeleton associated protein
leufactin (leukocyte F-actin binding protein)
leukocyte-specific protein 1
lymphocyte-specific protein 1
lymphocyte-specific protein pp52
pp52
WP34Lymphocyte-specific antigen WP34
Background
Lymphocyte-specific protein 1 (LSP1), also known as 47 kDa actin-binding protein, 52 kDa phosphoprotein, and Lymphocyte-specific antigen WP34, is an intracellular F-actin binding protein. LSP1 is expressed in lymphocytes, neutrophils, macrophages, and endothelium. LSP1 is also found in activated T-lymphocytes. LSP1 is known to function in neutrophil motility regulation, adhesion to fibrinogen matrix proteins, and trans-endothelial migration. LSP1 is phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. The phosphorylation by protein kinase C induces translocation of LSP1 from the cell membrane to the cytoplasm. Phosphorylation of LSP1 by MAPKAPK2 regulates neutrophil chemotaxis.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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