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Kir6.1 Antibody (S366-60) [DyLight 755]

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Product Details

Summary
Reactivity Hu, Mu, Rt, MaSpecies Glossary
Applications ICC/IF, IHC
Clone
S366-60
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 755

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 405
NBP2-59324AF405
Alexa Fluor 488
NBP2-59324AF488
Alexa Fluor 647
NBP2-59324AF647
Alexa Fluor 700
NBP2-59324AF700
Biotin
NBP2-59324B
DyLight 350
NBP2-59324UV
DyLight 405
NBP2-59324V
DyLight 488
NBP2-59324G
DyLight 550
NBP2-59324R
DyLight 650
NBP2-59324C
DyLight 680
NBP2-59324FR
FITC
NBP2-59324F
HRP
NBP2-59324H
Janelia Fluor 549
NBP2-59324JF549
Janelia Fluor 646
NBP2-59324JF646
Unconjugated
NBP2-59324
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Kir6.1 Antibody (S366-60) [DyLight 755] Summary

Immunogen
Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
Localization
Membrane
Specificity
Detects 45kDa.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
KCNJ8
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Use in Gerbil reported in scientific literature (PMID:31573045).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for Kir6.1 Antibody (S366-60) [DyLight 755]

  • ATP-sensitive inward rectifier potassium channel 8
  • Inward rectifier K(+) channel Kir6.1
  • inwardly rectifying potassium channel KIR6.1
  • KCNJ8
  • Kir6.1
  • Potassium channel, inwardly rectifying subfamily J member 8
  • potassium inwardly-rectifying channel, subfamily J, member 8
  • uKATP-1

Background

The Kir6.1 (KCNJ8) gene is essential in membrane function as it encodes an inward-rectifier potassium channel protein that is 424 amino acids long and has a mass of nearly 48 kDA. Dysfunctions in the Kir6.1 gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). Research is investigating its role in various diseases such as retinitis, hypoxia, pancreatitis, myocardial infarction, spasticity, leiomyoma, acute myocardial infarction, and prinzmetal angina. The Kir6.1 gene plays a significant role in ATP sensitive potassium channels, SIDS susceptibility pathways, dopamine feedback into cAMP pathway, and the CFTR-dependent regulation of ion channels in airway epithelium. It interacts with other genes such as KCNJ2, ABCC8, ABCC9, and KCNJ11.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol KCNJ8