Antibody was raised against a 17 amino acid peptide near the carboxy terminus of human KCNK1. The immunogen is located within amino acids 220 - 270 of KCNK1. Amino Acid Squence: DYVPGEGYNQKFRELYK
Specificity
KCNK1 antibody is predicted to not cross-react with other KCNK proteins.
35 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publication using NBP2-41301 in the following applications:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified
Alternate Names for KCNK1 Antibody - BSA Free
DPK
HOHO1
Inward rectifying potassium channel protein TWIK-1
K2P1
K2p1.1
KCNK1
KCNO1
Potassium channel KCNO1
potassium channel subfamily K member 1
potassium channel, subfamily K, member 1
potassium inwardly-rectifying channel, subfamily K, member 1
TWIK1
TWIK-1
TWIK1HOHO
Background
K+ channels are divided into three subclasses, reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions, and include TASK, TREK, TRAAK and TWIK. TWIK-1 mRNA is expressed abundantly in brain and at lower levels in lung, kidney and skeletal muscle. The molecular weight of TWIK-1 in mouse brain is 40 kDa under reducing conditions. TWIK-2 shares low sequence homology with other mammalian family group members, and only 34% homology with TWIK-1. Human TWIK-2 is expressed in pancreas, placenta and heart, while mouse TWIK-2 is expressed in liver. TWIK-2 is inhibited by intracellular, but not extracellular, acidification.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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