JNK1/2/3 Antibody (252355) [Unconjugated] - Pan Specific

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Members of the MAPK family, the c-Jun N-terminal kinases (JNKs) are activated by environmental stresses and inflammatory cytokines. Ten JNK isoforms are created by alternative splicing of mRNA transcripts derived from three genes: JNK1, JNK2, and JNK3. All JNKs are activated by dual phosphorylation; at T183/Y185 for JNK1 and 2, and T221/Y223 for JNK3. Activated JNKs translocate to the nucleus where they regulate the activity of several transcription factors; including the c-Jun component of AP-1 and ATF-2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 5 of 5.

Publications using MAB1387	Applications	Species
Hongbing Fan, Khushwant S. Bhullar, Zihan Wang, Jianping Wu Soybean-Derived Tripeptide Leu–Ser–Trp (LSW) Protects Human Vascular Endothelial Cells from TNF alpha -Induced Oxidative Stress and Inflammation via Modulating TNF alpha Receptors and SIRT1 Foods 10/26/2022 [PMID: 36359987]
Ö Boyac?o?lu, E Bilgiç, C Varan, E Bilensoy, E Nemutlu, D Sevim, Ç Kocaefe, P Korkusuz ACPA decreases non-small cell lung cancer line growth through Akt/PI3K and JNK pathways in vitro Cell Death & Disease, 2021-01-11;12(1):56. 2021-01-11 [PMID: 33431819] (Western Blot, Human)	Western Blot	Human
LCC Araujo, KB Feitosa, GM Murata, IC Furigo, SA Teixeira, CF Lucena, LM Ribeiro, MN Muscará, SKP Costa, J Donato, S Bordin, R Curi, CRO Carvalho Uncaria tomentosa improves insulin sensitivity and inflammation in experimental NAFLD Sci Rep, 2018-07-20;8(1):11013. 2018-07-20 [PMID: 30030460] (Western Blot, Mouse)	Western Blot	Mouse
M. Vieira, J. Fernandes, A. Burgeiro, G.M. Thomas, R.L. Huganir, C.B. Duarte et al. Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation Neurobiology of Disease 12/1/2010 [PMID: 20708684]
Bengochea A, de Souza MM, Lefrancois L, Le Roux E, Galy O, Chemin I, Kim M, Wands JR, Trepo C, Hainaut P, Scoazec JY, Vitvitski L, Merle P Common dysregulation of Wnt/Frizzled receptor elements in human hepatocellular carcinoma. Br. J. Cancer, 2008-06-24;99(1):143-50. 2008-06-24 [PMID: 18577996] (Western Blot, Human)	Western Blot	Human

Array MAB1387

• JNK1/2/3 Antibodies
• JNK1/2/3 ELISA