ISG15/UCRP Antibody (539442) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

ISG15 (interferon-induced 15 kDa protein; also known as IP17) is a 15 kDa ubiquitin family protein that is expressed by a wide variety of cell types. ISG15 is induced by type I IFN, and like ubiquitin, becomes conjugated to intracellular proteins. Unlike ubiquitin, it does not target proteins for degradation. Instead, it is part of the antivirus response. Human proISG15 is 165 amino acids (aa) in length. There are two ubiquitin-like domains (aa 2‑78 and 79‑157) and a propeptide (aa 158‑165) that is cleaved intracellularly. Select blood mononuclear cells secrete mature ISG15, which is chemotactic for neutrophils. Mature human ISG15 shares 66% aa sequence identity with mouse ISG15.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using MAB4845	Applications	Species
Lange C, Gouttenoire J, Duong F, Morikawa K, Heim M, Moradpour D Vitamin D receptor and Jak-STAT signaling crosstalk results in calcitriol-mediated increase of hepatocellular response to IFN-alpha. J Immunol, 2014-05-12;192(12):6037-44. 2014-05-12 [PMID: 24821973] (Western Blot, Human)	Western Blot	Human

Array MAB4845

• ISG15/UCRP Antibodies
• ISG15/UCRP ELISA Kits
• ISG15/UCRP Proteins
• ISG15/UCRP Proteins and Enzyme