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IL-31 Antibody (MT313)

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Neutralization: IL-31 Antibody (MT313) [NBP3-18293] - Neutralization of human IL-31 induced IL-6 production (see graph). To determine the neutralizing capacity and ND50, mixtures of human recombinant IL-31 (50 ng/ml) and various concentrations of NBP3-18293 were added to human aortic endothelial cells that had been pre-stimulated with recombinant human IFN-gamma (10 ng/ml). Following overnight incubation, cell supernatants were quantified in IL-6 ELISA.
Neutralization: IL-31 Antibody (MT313) [NBP3-18293] - Neutralization of human IL-31 induced IL-6 production (see graph). To determine the neutralizing capacity and ND50, mixtures of human recombinant IL-31 (50 ng/ml) ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications B/N
Clone
MT313
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

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IL-31 Antibody (MT313) Summary

Immunogen
Recombinant human IL-31
Specificity
Native and recombinant human IL-31
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IL31
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Neutralization

Packaging, Storage & Formulations

Storage
Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 um filtered PBS
Preservative
No Preservative
Concentration
1 mg/ml
Purity
Protein G purified

Alternate Names for IL-31 Antibody (MT313)

  • IL31
  • IL-31
  • IL-31interleukin-31
  • interleukin 31

Background

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting ofIL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma(Dillon et al., 2004 (PubMed 15184896)).(supplied by OMIM)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IL31