IL-17RD/SEF Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin -17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane (1‑5). The gene for this protein belongs to a synexpression group originally identified in zebrafish and SEF is expressed along with FGF-3, -8, sprouty-2 (SPRY2) and SPRY4 (6, 7). Due to the presence of an alternate start site, there is one transcript that potentially gives rise to two isoforms. The first is a full-length long form and the second an N-terminally truncated form (2, 5). The significance and expression pattern of the short form are uncertain. The membrane‑bound long form of mouse IL-17 RD is synthesized as a 738 amino acid (aa) precursor protein with a putative 27 aa signal peptide, a 272 aa extracellular domain, a 20 aa transmembrane segment and a 419 aa cytoplastic domain (5). The extracellular domain contains one Ig-like domain and a fibronectin type III motif. The cytoplasmic domain shares homology with the intracellular domains of IL-17 receptor family members and shows one TIR (Toll/IL-1 Receptor) domain and a putative TRAF6-binding motif (2). Natural IL-17 RD has been shown to form homomultimeric complexes (3). The full-length IL-17 RD isoform is expressed in most adult tissues and during embryonic development (3, 5). Functionally, IL-17 RD has been shown to be an inhibitor of FGF signaling. The molecule’s extracellular domain does not seem to be involved. There is an interaction between the intracellular domains of FGFR1/2 and IL-17 RD that blocks ERK dissociation from MEK, thereby interfering with downstream ERK activation of nuclear Elk-1 (8). IL-17 RD has also been reported to interact with TAK1 and induce JNK activation and apoptosis (9). Ligands that interact with the extracellular domain of IL-17 RD have not been identified.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Flow Cytometry, IHC-Fr, Immunoprecipitation, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using AF2276	Applications	Species
D Knizkova, M Pribikova, H Draberova, T Semberova, T Trivic, A Synackova, A Ujevic, J Stefanovic, A Drobek, M Huranova, V Niederlova, O Tsyklauri, A Neuwirth, J Tureckova, O Stepanek, P Draber CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology Nature Immunology, 2022-10-21;0(0):. 2022-10-21 [PMID: 36271145] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
ES Park, S Kim, DC Yao, JPJ Savarraj, HA Choi, PR Chen, E Kim Soluble Endoglin Stimulates Inflammatory and Angiogenic Responses in Microglia That Are Associated with Endothelial Dysfunction International Journal of Molecular Sciences, 2022-01-22;23(3):. 2022-01-22 [PMID: 35163148] (Western Blot, Mouse)	Western Blot	Mouse
Miraoui H, Dwyer A, Sykiotis G, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers T, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley W, Seminara S, Quinton R, Hughes V, Kumanov P, Young J, Yialamas M, Hall J, Van Vliet G, Chanoine J, Rubenstein J, Mohammadi M, Tsai P, Sidis Y, Lage K, Pitteloud N Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet, 2013-05-02;92(5):725-43. 2013-05-02 [PMID: 23643382] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Rong Z, Wang A, Li Z, Ren Y, Cheng L, Li Y, Wang Y, Ren F, Zhang X, Hu J, Chang Z IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling. Cell Res., 2009-02-01;19(2):208-15. 2009-02-01 [PMID: 19079364] (Immunoprecipitation, Western Blot, Mouse)	Immunoprecipitation, Western Blot	Mouse

Array AF2276

• IL-17RD/SEF Antibodies
• IL-17RD/SEF Antibody Pair
• IL-17RD/SEF Lysate
• IL-17RD/SEF Proteins
• IL-17RD/SEF Proteins and Enzymes