IL-1 beta/IL-1F2 Antibody

Interleukin-1 beta (IL-1 beta), also called IL-1F2, is a proinflammatory cytokine that functions in host defense following injury or inflammation (1-5). IL-1 beta is expressed by cells of the immune system such as monocytes, macrophage, neutrophils, and hepatocytes (1-3). Human IL-1 beta protein is expressed in the cytoplasm in an inactive precursor form (pro-IL-1 beta) which is 269 amino acids in length with a theoretical molecular weight of 31 kDa (1,4,6). Pro-IL-1 beta is cleaved by IL-1 converting enzyme (ICE), also called caspase-1, generating the 18 kDa mature, active protein that is secreted from cells (1,4,6). Pro-IL-1 beta is produced as a cellular response to molecular signals from pathogens and other processes termed pathogen associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs) (1,2). PAMPs and DAMPs signal through pattern recognition receptors (PRRs) to induce formation of the inflammasome (1,2). The inflammasome is a multi-protein complex made of a PRR, such as Nod-like receptor family, pyrin domain containing 3(NLRP3), an adaptor, such as apoptosis-associated spec-like protein containing a CARD (ASC), and pro-caspase-1 (1-3,5). Assembly of the inflammasome enables cleavage of pro-caspase-1 into active caspase 1, followed by secretion of activate IL-1 beta (1-3,5).

IL-1 beta binding to its receptor IL-1RI and the downstream signaling contributes to a dual pathophysiological role (3). On one hand, IL-1 beta signaling activates immune cells and drives CD4+ T cell polarization to T helper type 1 (Th1) and Th17 cells, resulting in anti-tumor responses and mediation of acute inflammation (2,3). However, IL-1 beta also supports tumor growth and metastasis driven by multiple mechanisms including chronic inflammation, an immunosuppressive tumor microenvironment (TME), and angiogenesis (3). Additionally, IL-1 beta signaling been implicated in the pathogenesis of neuroinflammatory diseases of the central nervous system (CNS) such as multiple sclerosis (MS), Alzheimer's disease, and diabetic retinopathy (DR) (2). Mouse studies have shown regression of tumors treated with IL-1 as well as protective effects of IL-1 beta in instances of induced colitis and colon carcinoma (3). Conversely, blocking IL-1 beta has also shown promising effect in cancer treatment, especially when combined with chemotherapeutics (2,3). Approved IL-1 beta monoclonal antibody canakinumab has shown significant therapeutic promise in the treatment of DR (2). Given its multifaceted role in disease, IL-1 beta is a promising therapeutic target.

References

1. Lopez-Castejon G, Brough D. Understanding the mechanism of IL-1beta secretion. Cytokine Growth Factor Rev. 2011;22(4):189-195. https://doi.org/10.1016/j.cytogfr.2011.10.001

2. Mendiola AS, Cardona AE. The IL-1beta phenomena in neuroinflammatory diseases. J Neural Transm (Vienna). 2018;125(5):781-795. https://doi.org/10.1007/s00702-017-1732-9

3. Bent R, Moll L, Grabbe S, Bros M. Interleukin-1 Beta-A Friend or Foe in Malignancies?. Int J Mol Sci. 2018;19(8):2155. https://doi.org/doi:10.3390/ijms19082155

4. Krumm B, Xiang Y, Deng J. Structural biology of the IL-1 superfamily: key cytokines in the regulation of immune and inflammatory responses. Protein Sci. 2014;23(5):526-538. https://doi.org/10.1002/pro.2441

5. He Y, Hara H, Nunez G. Mechanism and Regulation of NLRP3 Inflammasome Activation. Trends Biochem Sci. 2016;41(12):1012-1021. https://doi.org/10.1016/j.tibs.2016.09.002

6. Uniprot (P01584)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 8 confirmed species: Human, Mouse, Rat, Bacteria, Canine, Golden Syrian Hamster, Monkey, Porcine.

We have publications tested in 12 applications: Block/Neutralize, ELISA, EM, ICC/IF, IF/IHC, IHC-Fr, IHC-P, IHC-WhMt, IP, Immunohistochemistry, WB, Western Blot.

Showing Publications 1 - 10 of 104. Show All 104 Publications. Collapse Publications.

Publications using NB600-633	Applications	Species
Kim MH, Lim H, Kim OH et al. CD36 deficiency protects lipopolysaccharide-induced sepsis via inhibiting CerS6-mediated endoplasmic reticulum stress. International immunopharmacology 2024-10-25 [PMID: 39461238]
Han-Hee Na, Seil Kim, Jun‐Seob Kim, Soohyun Lee, Yeseul Kim, Su-Hyun Kim, Choong-Hwan Lee, Dohyeon Kim, Sung Ho Yoon, Haeyoung Jeong, Daehyuk Kweon, Hwi Won Seo, Choong-Min Ryu Facemask acne attenuation through modulation of indirect microbiome interactions NPJ Biofilms and Microbiomes 2024-06-20 [PMID: 38902263]
Hye Suk Baek, Victor Sukbong Hong, Hyunsu Kang, Sang-Jin Lee, Jin-Young Lee, Hyunju Kang, Seungik Jeong, Hyunho Jung, Jong Wook Park, Taeg Kyu Kwon, Chang-Nam Son, Sang Hyon Kim, Jinho Lee, Ki-Suk Kim, Shin Kim Anti-rheumatic property and physiological safety of KMU-11342 in in vitro and in vivo models. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024-06-15 [PMID: 38879731]
T. Ollewagen, R.M. Benecke, C. Smith High species homology potentiates quantitative inflammation profiling in zebrafish using immunofluorescence Heliyon 2023-12-13 [PMID: 38187273]
Florencia Sabbione, Irene Angelica Keitelman, Carolina Maiumi Shiromizu, Alexia Vereertbrugghen, Douglas Vera Aguilar, Paolo Nahuel Rubatto Birri, Manuela Pizzano, María Victoria Ramos, Federico Fuentes, Lucas Saposnik, Agostina Cernutto, Juliana Cassataro, Carolina Cristina Jancic, Jeremías Gaston Galletti, Marina Sandra Palermo, Analía Silvina Trevani, Andreas J. Baumler Regulation of human neutrophil IL-1 beta secretion induced by Escherichia coli O157:H7 responsible for hemolytic uremic syndrome PLOS Pathogens 2023-12-21 [PMID: 38127952]
Zhang Z, Li M, Tai Y et al. ZNF70 regulates IL-1? secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer Cellular signalling 2023-11-23 [PMID: 38000525]
Ahmed Sultan, Bassim Mohammad, Najah Rayish Hadi Oridonin supplementation attenuates atherosclerosis via NLRP-3 inflammasome pathway suppression Journal of Medicine and Life 2023-07-01 [PMID: 37900059]
Quan JH, Gao FF, Ma TZ et al. Toxoplasma gondii induces pyroptosis in human placental trophoblast and amniotic cells by inducing ROS production and activation of cathepsin B and NLRP1/NLRP3/NLRC4/AIM2 inflammasome The American journal of pathology 2023-09-21 [PMID: 37741453] (IHC-P, Mouse)	IHC-P	Mouse
Du H, Xu F, Liu J et al. Long-term aspirin administration suppresses inflammation in diabetic cystopathy Aging (Albany NY) 2023-09-12 [PMID: 37702622] (Western Blot)	Western Blot
Lan T, Zeng Q, Zhu Y et al. Xin-Li formula attenuates heart failure induced by a combination of hyperlipidemia and myocardial infarction in rats via Treg immunomodulation and NLRP3 inflammasome inhibition Journal of Traditional and Complementary Medicine 2023-09-01 [PMID: 37693100]
Ibrahim T, Wu P, Wang LJ et al. Sex-dependent differences in the genomic profile of lingual sensory neurons in na�ve and tongue-tumor bearing mice Scientific Reports 2023-08-12 [PMID: 37573456] (Immunohistochemistry)	Immunohistochemistry
Yu W, Jiang W, Wu W et al. Combining idebenone and rosuvastatin prevents atherosclerosis by suppressing oxidative stress and NLRP3 inflammasome activation European journal of pharmacology 2023-07-13 [PMID: 37451421] (WB, Mouse, Human) Details: 1:1000 dilution	WB	Mouse, Human
Zhang T, Zhang Y, Li S et al. Gentianella acuta-derived Gen-miR-1 suppresses myocardial fibrosis by targeting HAX1/HMG20A/Smads axis to attenuate inflammation in cardiac fibroblasts Phytomedicine : international journal of phytotherapy and phytopharmacology 2023-06-16 [PMID: 37352750] (WB, Mouse)	WB	Mouse
Oh DK, Na HS, Jhun JY et al. Bifidobacterium longum BORI inhibits pain behavior and chondrocyte death, and attenuates osteoarthritis progression PloS one 2023-06-23 [PMID: 37352198] (IHC-P, Rat)	IHC-P	Rat
Eid SA, Noureldein M, Kim B et al. Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination Journal of neurochemistry 2023-06-16 [PMID: 37328915] (ICC/IF, Mouse)	ICC/IF	Mouse
Yiu SPT, Zerbe C, Vanderwall D et al. An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation Molecular cell 2023-06-08 [PMID: 37311461] (WB, Human)	WB	Human
Li J, Wu C, Hu H et al. Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer Cancer cell 2023-05-09 [PMID: 37172580] (IHC-P, Mouse)	IHC-P	Mouse
Min HK, Na HS, Jhun J et al. Identification of gut dysbiosis in axial spondyloarthritis patients and improvement of experimental ankylosing spondyloarthritis by microbiome-derived butyrate with immune-modulating function Frontiers in immunology 2023-04-18 [PMID: 37143677] (IHC-P, Mouse)	IHC-P	Mouse
Wang G, Yin W, Shin H Et al. Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome Nature Aging 2021-11-01 [PMID: 37118341]
Yoon S, Hong H, Lim H et al. A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-kB pathway Acta Pharmaceutica Sinica B 2022-12-01 [PMID: 36970199] (IHC-P, Mouse)	IHC-P	Mouse
de Dios C, Abadin X, Roca-Agujetas V et al. Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis Translational neurodegeneration 2023-03-09 [PMID: 36895045] (Western Blot, Human)	Western Blot	Human
Yu S, Chung S, Ha H et al. Nanotheranostics of Pre Stenotic Vessels By Target Touch On Signaling of Peptide Navigator Advanced Functional Materials 2021-12-08 (WB)	WB
Ouhaddi Y, Charbonnier B, Porge J et al. Development of Neovasculature in Axially Vascularized Calcium Phosphate Cement Scaffolds Journal of functional biomaterials 2023-02-14 [PMID: 36826904] (IHC-P, Rat)	IHC-P	Rat
Ibrahim T, Wu P, Wang LJ et al. Sex-dependent Differences in the Genomic Profile of Lingual Sensory Neurons in Naïve and Tongue-Tumor Bearing Mice bioRxiv : the preprint server for biology 2023-05-14 [PMID: 36711730] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Hwang S, Kim SH, Yoo KH et al. Exogenous 8-hydroxydeoxyguanosine attenuates doxorubicin-induced cardiotoxicity by decreasing pyroptosis in H9c2 cardiomyocytes BMC molecular and cell biology 2022-12-14 [PMID: 36517746]
Park JS, Yang SC, Jeong HY et al. EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis Arthritis research & therapy 2022-11-17 [PMID: 36397156] (IHC-P, Mouse) Details: Dilution used in IHC-P 1:400	IHC-P	Mouse
Lee WH, Rho JG, Yang Y et al. Hyaluronic Acid Nanoparticles as a Topical Agent for Treating Psoriasis ACS nano 2022-11-14 [PMID: 36373736]
Cho KH, Na HS, Jhun J et al. Lactobacillus (LA-1) and butyrate inhibit osteoarthritis by controlling autophagy and inflammatory cell death of chondrocytes Frontiers in Immunology 2022-10-17 [PMID: 36325344] (Immunohistochemistry)	Immunohistochemistry
Gao P, Wu B, Ding Y et al. circEXOC5 promotes acute lung injury through the PTBP1/Skp2/Runx2 axis to activate autophagy Life science alliance 2023-01-01 [PMID: 36302650] (ICC/IF, Mouse)	ICC/IF	Mouse
Singh R, Chandel S, Ghosh A et al. Glucogallin Attenuates the LPS-Induced Signaling in Macrophages and Protects Mice against Sepsis International Journal of Molecular Sciences 2022-09-24 [PMID: 36232563] (Block/Neutralize)	Block/Neutralize
Liu X, Bae C, Liu B et al. Development of opioid-induced hyperalgesia depends on reactive astrocytes controlled by Wnt5a signaling Molecular Psychiatry 2023-02-01 [PMID: 36203006] (Immunohistochemistry, Western Blot, Block/Neutralize)	Immunohistochemistry, Western Blot, Block/Neutralize
Keitelman IA, Shiromizu CM, Zgajnar NR et al. The interplay between serine proteases and caspase-1 regulates the autophagy-mediated secretion of Interleukin-1 beta in human neutrophils Frontiers in immunology 2022-08-25 [PMID: 36091026] (WB, Human)	WB	Human
Khan AN, Singh R, Bhattacharya A et al. Glucogallin Attenuates RAW 264.7 Cells from Arsenic Trioxide Induced Toxicity via the NF-kappa B/NLRP3 Pathway Molecules (Basel, Switzerland) 2022-08-18 [PMID: 36014502] (ICC/IF, Human)	ICC/IF	Human
Zhang C, Guo DF, Lv GF et al. The ciliary protein Spef2 stimulates acinar Ampk?/Sirt1 signaling and ameliorates acute pancreatitis and associated lung injury Annals of Translational Medicine 2022-07-01 [PMID: 35965828]
Ottone OK, Kim CJ, Collins JA, Risbud MV. The cGAS-STING Pathway Affects Vertebral Bone but Does Not Promote Intervertebral Disc Cell Senescence or Degeneration Frontiers in Immunology 2022-06-13 [PMID: 35769461]
Na HS, Woo JS, Kim JH et al. Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death PloS one 2022-06-24 [PMID: 35749420] (IF/IHC, Rat)	IF/IHC	Rat
L Zhu, W Qi, G Yang, Y Yang, Y Wang, L Zheng, Y Fu, X Cheng Toxoplasma gondii Rhoptry Protein 7 (ROP7) Interacts with NLRP3 and Promotes Inflammasome Hyperactivation in THP-1-Derived Macrophages Cells, 2022-05-12;11(10):. 2022-05-12 [PMID: 35626667]
Chen P, Wu H, Yao H et al. Multi-Omics Analysis Reveals the Systematic Relationship Between Oral Homeostasis and Chronic Sleep Deprivation in Rats Frontiers in Immunology 2022-03-31 [PMID: 35432311] (Immunohistochemistry)	Immunohistochemistry
Ellegast JM, Alexe G, Hamze A et al. Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts Cancer Discovery 2022-07-06 [PMID: 35405016]
AK Rohlfing, K Kolb, M Sigle, M Ziegler, A Bild, P Münzer, J Sudmann, V Dicenta, T Harm, MC Manke, S Geue, M Kremser, M Chatterjee, C Liang, H von Eysmon, T Dandekar, D Heinzmann, M Günter, S von Ungern, M Büttcher, T Castor, S Mencl, F Langhauser, K Sies, D Ashour, MC Beker, M Lämmerhofe, SE Autenrieth, TE Schäffer, S Laufer, P Szklanna, P Maguire, M Heikenwald, KAL Müller, DM Hermann, E Kilic, R Stumm, G Ramos, C Kleinschni, O Borst, HF Langer, D Rath, M Gawaz ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury Nature Communications, 2022-04-05;13(1):1823. 2022-04-05 [PMID: 35383158]
Marconi GD, Della Rocca Y, Fonticoli L et al. The Beneficial Effect of Carvacrol in HL-1 Cardiomyocytes Treated with LPS-G: Anti-Inflammatory Pathway Investigations Antioxidants (Basel, Switzerland) 2022-02-15 [PMID: 35204269] (ICC/IF, Mouse)	ICC/IF	Mouse
Park JS, Lee D, yang S et al. Methotrexate-loaded nanoparticles ameliorate experimental model of autoimmune arthritis by regulating the balance of interleukin-17-producing T cells and regulatory T cells Journal of translational medicine 2022-02-11 [PMID: 35148758]
Liu X, Bae C, Gelman BB et al. A neuron-to-astrocyte Wnt5a signal governs astrogliosis during HIV-associated pain pathogenesis Brain : a journal of neurology 2022-01-18 [PMID: 35040478]
Zhou T, He C, Lai P et al. miR-204-containing exosomes ameliorate GVHD-associated dry eye disease Science advances 2022-01-14 [PMID: 35020440] (WB, Mouse)	WB	Mouse
Ashraf-Uz-Zaman M, Ji G, Tidwell D et al. Evaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis ACS chemical neuroscience 2022-01-19 [PMID: 34978174]
Hsu-Wen Tseng, Irina Kulina, Dorothée Girard, Jules Gueguen, Cedryck Vaquette, Marjorie Salga, Whitney Fleming, Beulah Jose, Susan M Millard, Allison R Pettit, Kate Schroder, Gethin Thomas, Lawrie Wheeler, François Genêt, Sébastien Banzet, Kylie A Alexander, Jean-Pierre Lévesque Interleukin-1 Is Overexpressed in Injured Muscles Following Spinal Cord Injury and Promotes Neurogenic Heterotopic Ossification. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022-04-15 [PMID: 34841579]
Xing Y, Wang JY, Li MY et al. Convallatoxin inhibits IL-1 beta production by suppressing zinc finger protein 91-mediated pro-IL-1 beta ubiquitination and caspase-8 inflammasome activity British journal of pharmacology 2021-11-26 [PMID: 34825365] (WB)	WB
Ollewagen T, Powrie YSL, Myburgh KH, Smith C Unresolved intramuscular inflammation, not diminished skeletal muscle regenerative capacity, is at the root of rheumatoid cachexia: insights from a rat CIA model Physiological reports 2021-11-01 [PMID: 34806343] (WB, Rat)	WB	Rat
Liu Y, Peng L, Li L Et al. 3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model Biomaterials 2021-12-01 [PMID: 34739982] (IF/IHC, Rat)	IF/IHC	Rat
Penolazzi L, Bergamin LS, Lambertini E Et al. The P2X7 purinergic receptor in intervertebral disc degeneration Journal of cellular physiology 2021-10-19 [PMID: 34668208] (IHC-P, Human)	IHC-P	Human
Wang JY, Xing Y, Li MY Et al. Panaxadiol inhibits IL-1 beta secretion by suppressing zinc finger protein 91-regulated activation of non-canonical caspase-8 inflammasome and MAPKs in macrophages Journal of ethnopharmacology 2021-10-12 [PMID: 34648898] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Boss MK, Ke Y, Bian L Et al. Therapeutic intervention using a Smad7-based Tat protein to treat radiation- induced oral mucositis International journal of radiation oncology, biology, physics 2021-10-02 [PMID: 34610386]
Chhabra G, Singh CK, GuzmAn-PErez G Et al. Anti-melanoma effects of concomitant inhibition of SIRT1 and SIRT3 in BrafV600E/PtenNULL mice The Journal of investigative dermatology 2021-09-28 [PMID: 34597611]
Risbud M, Novais E, Tran V, et al. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice Nat Commun 2021-09-04 [PMID: 34480023]
Kelly SB, Stojanovska V, Zahra VA et al. Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep Journal of Neuroinflammation 2021-12-01 [PMID: 34465372]
Liu X, Liu BL, Yang Q et al. Microglial ablation does not affect opioid-induced hyperalgesia in rodents Pain 2022-03-01 [PMID: 34433775]
Ramachandran A, Kumar B, Waris G, Everly D Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells Microbiology spectrum 2021-08-25 [PMID: 34431717]
Ma X, Qiang P, Chen G Et Al. Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1 beta Pathway Evidence-based complementary and alternative medicine : eCAM 2021-07-12 [PMID: 34335814] (WB, ICC/IF)	WB, ICC/IF
Kuang H, Wang T, Liu L Et Al. Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis Neuroscience letters 2021-07-23 [PMID: 34311053] (WB)	WB
Cau SB, Bruder-Nascimento A, Silva MB et al. Angiotensin-II activates vascular inflammasome and induces vascular damage Vascular pharmacology 2021-06-09 [PMID: 34098096]
Velasquez-Torres M, Shibayama-Salas M, Pacheco-Yepez J et al. (-)-Epicatechin protects from amebic liver abscess development in hamster Experimental parasitology 2021-03-23 [PMID: 33771537] (IF/IHC, Golden Syrian Hamster)	IF/IHC	Golden Syrian Hamster
Fidler TP, Xue C, Yalcinkaya M et al. The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis Nature 2021-03-17 [PMID: 33731931] (ICC/IF, Mouse)	ICC/IF	Mouse
Liu F, Liu T, Sun M et al. Maxing Shigan Decoction Mitigates Mycoplasma pneumonia-Induced Pyroptosis in A549 Cells via the NLRP3 Inflammasome Infection and drug resistance 2021-03-03 [PMID: 33688221] (WB, Human)	WB	Human
Park WJ, Han JS Gryllus bimaculatus extract protects against lipopolysaccharide and palmitate-induced production of proinflammatory cytokines and inflammasome formation Molecular medicine reports 2021-03-01 [PMID: 33495809]
Lliberos C, Liew SH, Zareie P, et al. Evaluation of inflammation and follicle depletion during ovarian ageing in mice Scientific reports 2021-01-11 [PMID: 33432051] (WB, Mouse)	WB	Mouse
Yang B, Maddison LA, Zaborska KE et al. RIPK3-mediated inflammation is a conserved beta cell response to ER stress Science advances 2020-12-01 [PMID: 33355143] (ICC/IF, Human, Mouse)	ICC/IF	Human, Mouse
Qin Y, Wang C, Xu S et al. G protein-coupled receptor 30 activation protects hepatic ischemia-reperfusion injury of liver tissue through inhibiting NLRP3 in the rat model J Histotechnol 2020-11-19 [PMID: 33210578] (Rat)		Rat
Yudhawati R, Amin M, Rantam FA et al. Bone marrow-derived mesenchymal stem cells attenuate pulmonary inflammation and lung damage caused by highly pathogenic avian influenza A/H5N1 virus in BALB/c mice BMC Infect Dis 2020-11-11 [PMID: 33176722] (IHC-P, Mouse) Details: Immunohistochemical analysis of mouse lung that had been damaged by avian influenza A/H5N1.	IHC-P	Mouse
Silva GB, Gierman LM, Rakner JJ et al. Cholesterol Crystals and NLRP3 Mediated Inflammation in the Uterine Wall Decidua in Normal and Preeclamptic Pregnancies Front Immunol 2020-10-01 [PMID: 33117348] (IHC-P, Human)	IHC-P	Human
Baek HS, Min HJ, Hong VS et al. Anti-Inflammatory Effects of the Novel PIM Kinase Inhibitor KMU-470 in RAW 264.7 Cells through the TLR4-NF-kappa B-NLRP3 Pathway Int J Mol Sci 2020-07-20 [PMID: 32698512] (IP, Mouse)	IP	Mouse
Wang Y, Ji N, Gong X et al. Thioredoxin-1 attenuates atherosclerosis development through inhibiting NLRP3 inflammasome Endocrine 2020-06-30 [PMID: 32607763] (WB)	WB
Wei Jiang, Hongzhi Geng, Xiaoqing Lv Idebenone protects against atherosclerosis in apolipoprotein E-deficient mice via activation of the Sirt3-SOD2-mtROS pathway Cardiovasc Drugs Ther 2020-06-20 [PMID: 32557012]
Davis JA, Bopp AC, Henwood MK et al. Pharmacological transection of brain-spinal cord communication blocks pain-induced hemorrhage and locomotor deficits after spinal cord injury in rats J. Neurotrauma 2020-05-05 [PMID: 32368946] (WB)	WB
Renema P, Hardy Ks, Housley N et Al. cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection Am. J. Physiol. Lung Cell Mol. Physiol. 2020-03-18 [PMID: 32186399]
Xu Y, Xu Y, Zhu Y et al. Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis Mol. Ther. 2019-09-12 [PMID: 31604677]
Lambert WS, Carlson BJ, Ghose P et al. Towards A Microbead Occlusion Model of Glaucoma for a Non-Human Primate Sci Rep 2019-08-09 [PMID: 31399621] (IHC-Fr, IHC-WhMt, Monkey) Details: Male Bolivian squirrel monkeys (Saimiri boliviensis) were used as part of this study.	IHC-Fr, IHC-WhMt	Monkey
Zheng SH, Yan CY, Duan N et al. Penehyclidine hydrochloride suppressed peripheral nerve injury-induced neuropathic pain by inhibiting microglial MAPK/p-p38/IL-1 beta pathway activation Mol Pain 2019-06-01 [PMID: 31149893] (ICC/IF, Rat)	ICC/IF	Rat
Tavares Pereira M, Gram A, Nowaczyk R et al. Prostaglandin-mediated effects in early canine corpus luteum: In vivo effects on vascular and immune factors Reprod Biol 2019-03-28 [PMID: 30929911] (IHC-P, Canine)	IHC-P	Canine
Kaiko GE, Chen F, Lai CW et al. PAI-1 augments mucosal damage in colitis Sci Transl Med 2019-03-06 [PMID: 30842312] (WB, Human)	WB	Human
Novais EM, Diekman BO, Shapiro IM, Risbud MV. p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence Matrix Biol. 2019-02-24 [PMID: 30811968] (IHC-P, Mouse)	IHC-P	Mouse
Ma X, Chang Y, Xiong Y et al. Eplerenone Ameliorates Cell Pyroptosis in Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction Nephron 2019-02-21 [PMID: 30799394] (IHC-P, Rat)	IHC-P	Rat
Gorth DJ, Shapiro IM, Risbud MV. Transgenic mice overexpressing human TNF-a experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration. Cell Death Dis 2018-12-18 [PMID: 30584238] (ICC/IF, Mouse)	ICC/IF	Mouse
Mi, C, Wang, Z Et al. Zinc finger protein 91 positively regulates the production of IL-1 beta in macrophages by activation of MAPKs and non-canonical caspase-8 inflammasome. Br J Pharmacol 2018-12-01 [PMID: 30182366] (WB, Human)	WB	Human
Cheon SY, Kim JM, Kim EJ et al. Intranuclear delivery of synthetic nuclear factor-kappa B p65 reduces inflammasomes after surgery Biochem. Pharmacol. 2018-08-07 [PMID: 30096289] (WB, Mouse)	WB	Mouse
Bajpai G, Schneider C, Wong N et al. The human heart contains distinct macrophage subsets with divergent origins and functions Nat. Med. 2018-06-11 [PMID: 29892064] (IHC-P, Human)	IHC-P	Human
Stodle GS, Silva GB, Tangeras LH et al. Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts. Clin. Exp. Immunol. 2018-04-23 [PMID: 29683202] (IF/IHC)	IF/IHC
Lin ZH, Wang SY, Chen LL et al. Methylene Blue Mitigates Acute Neuroinflammation after Spinal Cord Injury through Inhibiting NLRP3 Inflammasome Activation in Microglia Front Cell Neurosci 2017-12-11 [PMID: 29311826] (WB, Rat)	WB	Rat
Cheng Ran, Liu Wen, Zhang Rui et al. Porphyromonas gingivalis-Derived Lipopolysaccharide Combines Hypoxia to Induce Caspase-1 Activation in Periodontitis. Frontiers in Cellular and Infection Microbiology 2017-01-01 [PMID: 29184853] (WB, Mouse)	WB	Mouse
Gorth DJ The Role of TNF alpha and IL-1 beta in Intervertebral Disc Disease and Health Thesis 2021-01-01
Wei Jiang, Hongzhi Geng, Xiaoqing Lv Idebenone protects against atherosclerosis in apolipoprotein E-deficient mice via activation of the Sirt3-SOD2-mtROS pathway assets.researchsquare.com (WB, Mouse)	WB	Mouse
Kishore D, Gopal A, Gambhir I, Diwaker A Aging immunity, immunosenescence, or inflamm-aging: A comparative study of cytokines J Med Soc 2019-10-14 (ELISA, Human)	ELISA	Human
Komiya H, Shimizu K, Noma N et al. Role of Neuron-Glial Interaction Mediated by IL-1b in Ectopic Tooth Pain J. Dent. Res. 2017-11-01 [PMID: 29131694] (WB)	WB
Su B, Luo T, Zhu J et al. Interleukin-1B/IRAK-1 inflammatory signaling contributes to persistent gankyrin activation during hepatocarcinogenesis. Hepatology. 2014-10-07 [PMID: 25294684] (IHC-P, WB, Human, Rat)	IHC-P, WB	Human, Rat
Arendt LM, McCready J, Keller PJ et al. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer research. 2013-10-01 [PMID: 23959857] (IP, WB, Mouse)	IP, WB	Mouse
Paino A, Ahlstrand T, Nuutila J et al. Identification of a Novel Bacterial Outer Membrane Interleukin-1beta-Binding Protein from Aggregatibacter actinomycetemcomitans. PLoS One 2013-07-31 [PMID: 23936223] (WB, Bacteria)	WB	Bacteria
Paino A, Tuominen H, Jaaskelainen M et al. Trimeric Form of Intracellular ATP Synthase Subunit [beta] of Aggregatibacter actinomycetemcomitans Binds Human Interleukin-1[beta]. PLoS One;6(4). 2011-04-18 [PMID: 21533109]
Petrovski G, Ayna G, Majai G et al. Phagocytosis of cells dying through autophagy induces inflammasome activation and IL-1 beta release in human macrophages. Autophagy. 2011-03-01 [PMID: 21217200] (WB, Human)	WB	Human
Ahlstrand T, Tuominen H, Beklen A et al. A novel intrinsically disordered outer membrane lipoprotein of Aggregatibacter actinomycetemcomitans binds various cytokines and plays a role in biofilm response to interleukin-1beta and interleukin-8. Virulence 2017-02-17 [PMID: 27459270]
Li F, Wang C, Wang J et al. Resveratrol Attenuates Exercise-induced Acute Kidney Injury by Inhibiting NLRP3 Inflammasome-mediated Renal Tubular Pyroptosis Research Square 2023-07-24 (WB, Rat)	WB	Rat
Ahmad F, Chung YW, Tang Y et al. Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci Rep 2016-06-20 [PMID: 27321128] (WB, Mouse)	WB	Mouse
Rossi AF, Cadamuro AC, Biselli-Perico JM et al. Interaction between inflammatory mediators and miRNAs in Helicobacter pylori infection. Cell. Microbiol. 2016-03-04 [PMID: 26945693] (IHC-P, Human)	IHC-P	Human
Bimpis A, Papalois A, Voumvourakis K et al. Neuronal tumour necrosis factor-alpha and interleukin-1beta expression in a porcine model of intracerebral haemorrhage: Modulation by U-74389G Brain Res. 2015-04-25 [PMID: 25916578] (IHC-P, Porcine)	IHC-P	Porcine
Paino A, Lohermaa E, Sormunen R et al. Interleukin-1 beta is internalised by viable Aggregatibacter actinomycetemcomitans biofilm and locates to the outer edges of nucleoids Cytokine 2012-08-13 [PMID: 22898394] (EM, IF/IHC, Bacteria)	EM, IF/IHC	Bacteria
Show All 104 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Armen Petrosyan	WB	Mouse	11/20/2024	View Summary Application Western Blot Sample Tested Liver homogenates sample Species Mouse Lot 33815
Enlarge	3 reviewed by: seulgee lee	WB	raw264.7	04/24/2018	View Summary Application Western Blot Sample Tested cell Species raw264.7 Lot 33815
Enlarge	5 reviewed by: Verified Customer	IF	Other	01/07/2016	View Summary Application Immunofluorescence Sample Tested trabecular meshwork (TM) region of pig eyes Species Other
Enlarge	4 reviewed by: Verified Customer	WB	Other	11/25/2014	View Summary Application Western Blot Sample Tested Fetal membranes Species Other
Enlarge	4 reviewed by: Leonid Tarassishin	WB	Human	04/28/2014	View Summary Application Western Blot Sample Tested glioblastoma cell lysates Species Human Lot 25270

Array NB600-633

• IL-1 beta/IL-1F2 Antibodies
• IL-1 beta/IL-1F2 ELISA Kits
• IL-1 beta/IL-1F2 Lysate
• IL-1 beta/IL-1F2 Proteins
• IL-1 beta/IL-1F2 ELISAs
• IL-1 beta/IL-1F2 Proteins and Enzymes