IL-1 beta/IL-1F2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2, IL1B), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 17% amino acid (aa) identity in mouse. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. The 17 kDa molecular weight mature mouse IL-1 beta shares 90% aa sequence identity with cotton rat and rat and 67%-78% with canine, equine, feline, human, porcine, and rhesus macaque IL-1 beta . IL-1 beta functions in a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Neutralization, Western Blot.

Showing Publications 1 - 10 of 29. Show All 29 Publications. Collapse Publications.

Publications using AB-401-NA	Applications	Species
Zhao, C;Sun, L;Zhang, Y;Shu, X;Hu, Y;Chen, D;Zhang, Z;Xia, S;Yang, H;Bao, X;Li, J;Xu, Y; Thymol improves ischemic brain injury by inhibiting microglia-mediated neuroinflammation Brain research bulletin 2024-07-14 [PMID: 39009094] (Western Blot, Mouse)	Western Blot	Mouse
Li, Y;Zhuang, Y;Chen, Y;Wang, G;Tang, Z;Zhong, Y;Zhang, Y;Wu, L;Ji, X;Zhang, Q;Pan, B;Luo, Y; Euphorbia factor L2 alleviated gouty inflammation by specifically suppressing both the priming and activation of NLRP3 inflammasome International immunopharmacology 2024-07-08 [PMID: 38981223] (Western Blot, Mouse)	Western Blot	Mouse
J Feng, W Meng, L Chen, X Zhang, A Markazi, W Yuan, Y Huang, SJ Gao N6-Methyladenosine and Reader Protein YTHDF2 Enhance the Innate Immune Response by Mediating DUSP1 mRNA Degradation and Activating Mitogen-Activated Protein Kinases during Bacterial and Viral Infections MBio, 2023-01-10;0(0):e0334922. 2023-01-10 [PMID: 36625590] (Western Blot, Mouse)	Western Blot	Mouse
Lin WY, Li LH, Hsiao YY et al. Repositioning of the Angiotensin II Receptor Antagonist Candesartan as an Anti-Inflammatory Agent With NLRP3 Inflammasome Inhibitory Activity Frontiers in Immunology 2022-05-20 [PMID: 35669789]
Lin WY, Li LH, Hsiao YY et al. Repositioning of the Angiotensin II Receptor Antagonist Candesartan as an Anti-Inflammatory Agent With NLRP3 Inflammasome Inhibitory Activity Frontiers in Immunology 5/20/2022 [PMID: 35669789]
S Arumugam, Y Qin, Z Liang, SN Han, SLT Boodapati, J Li, Q Lu, RA Flavell, WZ Mehal, X Ouyang GSK3beta mediates the spatiotemporal dynamics of NLRP3 inflammasome activation Cell Death and Differentiation, 2022-04-27;0(0):. 2022-04-27 [PMID: 35477991] (Western Blot, Mouse)	Western Blot	Mouse
X Ding, H Kambara, R Guo, A Kanneganti, M Acosta-Zal, J Li, F Liu, T Bei, W Qi, X Xie, W Han, N Liu, C Zhang, X Zhang, H Yu, L Zhao, F Ma, JR Köhler, HR Luo Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages Nature Communications, 2021-11-18;12(1):6699. 11/18/2021 [PMID: 34795266]
GM Childers, CA Perry, B Blachut, N Martin, CD Bortner, S Sieber, JL Li, MB Fessler, GJ Harry Assessing the Association of Mitochondrial Function and Inflammasome Activation in Murine Macrophages Exposed to Select Mitotoxic Tri-Organotin Compounds Environmental health perspectives, 2021-04-30;129(4):47015. 2021-04-30 [PMID: 33929904] (Western Blot, Mouse)	Western Blot	Mouse
Wu CH, Gan CH, Li LH et al. A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction Frontiers in Immunology 12/18/2020 [PMID: 33424855]
Wu CH, Gan CH, Li LH et al. A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction Frontiers in Immunology 2020-12-18 [PMID: 33424855]
K Sato, A Tobo, C Mogi, M Tobo, N Yamane, M Tosaka, H Tomura, DS Im, F Okajima The protective role of proton-sensing TDAG8 in the brain injury in a mouse ischemia reperfusion model Sci Rep, 2020-10-14;10(1):17193. 2020-10-14 [PMID: 33057165] (Western Blot, Mouse)	Western Blot	Mouse
Hamida Saleh, Atef M. K. Nassar, Ahmed E. Noreldin, Dalia Samak, Norhan Elshony, Lamiaa Wasef et al. Chemo-Protective Potential of Cerium Oxide Nanoparticles against Fipronil-Induced Oxidative Stress, Apoptosis, Inflammation and Reproductive Dysfunction in Male White Albino Rats Molecules 7/31/2020 [PMID: 32751827]
Lan-Hui Li, Tzu-Ling Chen, Hsiao-Wen Chiu, Chung-Hua Hsu, Chien-Chun Wang, Tzu-Ting Tai et al. Critical Role for the NLRP3 Inflammasome in Mediating IL-1 beta Production in Shigella sonnei-Infected Macrophages Frontiers in Immunology 6/3/2020 [PMID: 32582195]
YH Jeong, MC Walsh, J Yu, H Shen, EJ Wherry, Y Choi Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes J. Immunol., 2020-06-15;0(0):. 2020-06-15 [PMID: 32540996] (Western Blot, Mouse)	Western Blot	Mouse
Hsiao-Wen Chiu, Lan-Hui Li, Chih-Yu Hsieh, Yerra Koteswara Rao, Fang-Hsin Chen, Ann Chen et al. Glucosamine inhibits IL-1 beta expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome Scientific Reports 4/3/2019 [PMID: 30944389]
H Nakazawa, K Ikeda, S Shinozaki, S Yasuhara, YM Yu, JAJ Martyn, RG Tompkins, T Yorozu, S Inoue, M Kaneki Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle FEBS Open Bio, 2019-01-19;9(2):348-363. 2019-01-19 [PMID: 30761259] (Western Blot, Mouse)	Western Blot	Mouse
J Chen, ZJ Chen PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation Nature, 2018-11-28;564(7734):71-76. 2018-11-28 [PMID: 30487600] (Western Blot, Mouse)	Western Blot	Mouse
Wong WT, Li LH, Rao YK et al. Repositioning of the B-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol 8/22/2018 [PMID: 30186288]
Xiaoli Tian, He Sun, Amy-Jo Casbon, Edward Lim, Kevin P. Francis, Judith Hellman et al. NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice Frontiers in Immunology 10/31/2017 [PMID: 29163464]
Karen V. Swanson, Robert D. Junkins, Cathryn J. Kurkjian, Elizabeth Holley-Guthrie, Avani A. Pendse, Rachid El Morabiti et al. A noncanonical function of cGAMP in inflammasome priming and activation Journal of Experimental Medicine 12/4/2017 [PMID: 29030458]
Wang H, Hong L, Huang J, Jiang Q, Tao R, Tan C, Lu N, Wang C, Ahmed M, Lu Y, Liu Z, Shi W, Lai E, Wilcox C, Han F P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy. Cell Res, 2015-05-22;25(6):674-90. 2015-05-22 [PMID: 25998681] (Neutralization, Mouse)	Neutralization	Mouse
Coll R, Robertson A, Chae J, Higgins S, Munoz-Planillo R, Inserra M, Vetter I, Dungan L, Monks B, Stutz A, Croker D, Butler M, Haneklaus M, Sutton C, Nunez G, Latz E, Kastner D, Mills K, Masters S, Schroder K, Cooper M, O'Neill L A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med, 2015-02-16;21(3):248-55. 2015-02-16 [PMID: 25686105] (Western Blot, Mouse)	Western Blot	Mouse
Zhao Y, Xiao X, Frank S, Lin H, Xia Y Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta. Am J Physiol Endocrinol Metab, 2014-06-03;307(2):E186-98. 2014-06-03 [PMID: 24895283] (Neutralization, Mouse)	Neutralization	Mouse
Sonia Lacroix-Lamandé, Martine Fanton Fanton d’Andon, Eric Michel, Gwenn Ratet, Dana J. Philpott, Stephen E. Girardin et al. Downregulation of the Na/K-ATPase Pump by Leptospiral Glycolipoprotein Activates the NLRP3 Inflammasome The Journal of Immunology 3/15/2012 [PMID: 22323544]
Chong-Shan Shi, Kevin Shenderov, Ning-Na Huang, Juraj Kabat, Mones Abu-Asab, Katherine A. Fitzgerald et al. Activation of autophagy by inflammatory signals limits IL-1 beta production by targeting ubiquitinated inflammasomes for destruction Nature Immunology 3/1/2012 [PMID: 22286270]
Reed JR, Leon RP, Hall MK, Schwertfeger KL Interleukin-1beta and fibroblast growth factor receptor 1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesis. Breast Cancer Res., 2009-04-24;11(2):R21. 2009-04-24 [PMID: 19393083] (Neutralization, Mouse)	Neutralization	Mouse
Taki N, Tatro JM, Lowe R, Goldberg VM, Greenfield EM Comparison of the roles of IL-1, IL-6, and TNFalpha in cell culture and murine models of aseptic loosening. Bone, 2006-12-21;40(5):1276-83. 2006-12-21 [PMID: 17236833] (Neutralization, Mouse)	Neutralization	Mouse
Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes Dev., 2006-09-15;20(18):2527-38. 2006-09-15 [PMID: 16980582] (Neutralization, Mouse)	Neutralization	Mouse
Show All 29 Publications. Collapse Publications.

Array AB-401-NA

• IL-1 beta/IL-1F2 Antibodies
• IL-1 beta/IL-1F2 ELISA Kits
• IL-1 beta/IL-1F2 Lysate
• IL-1 beta/IL-1F2 Proteins
• IL-1 beta/IL-1F2 ELISAs
• IL-1 beta/IL-1F2 Proteins and Enzymes