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IFN-beta Antibody [Unconjugated]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications B/N
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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IFN-beta Antibody [Unconjugated] Summary

Immunogen
Recombinant mouse IFN-beta
Specificity
Detects mouse IFN-beta .
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
IFNB1
Purity Statement
Antigen Affinity-purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Neutralization
Publications
Read Publications using
32401-1 in the following applications:

Packaging, Storage & Formulations

Storage
After receipt, the product may be stored at -20°C for short-term use (≤ 6 months). For long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum.Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).
Buffer
0.3 M Sodium Bicarbonate, 0.2 M Sodium Chloride.
Preservative
No Preservative

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-beta Antibody [Unconjugated]

  • Fibroblast interferon
  • IFB
  • IFBIFNB
  • IFF
  • IFNB
  • IFNB1
  • IFNbeta
  • IFN-beta
  • interferon beta
  • interferon, beta 1, fibroblast
  • MGC96956

Background

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.
Asselin-Paturel et al. (J Exp. Med, 2005) used 32400 in combination with Rabbit anti-mouse IFN-alpha (32100) to explore the role of Type I IFN in the migration and activation of dendritic cells. Kamath et al. (J. Immunol. 2005) used a similar cocktail to demonstrate that dendritic cell derived Type I IFN stimulates bystander T-cells.
Seimon et al. (PNAS, 2006) used 32400 to examine the role of IFN Beta in protecting LPS treated macrophages from apoptosis. Zheng et al. (J. Biol. Chem, 2006) used 32400 to examine the role of autocrine IFN Beta in RANKL stimulated iNOS expression in macrophages.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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IFN-beta Antibody
[Unconjugated]
32401-1
IFN-beta Antibody [Unconjugated]
Species: Mu
Applications: B/N

Publications for IFN-beta Antibody (32401-1)(3)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Neutralization.


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Neutralization
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FAQs for IFN-beta Antibody (32401-1) (0)

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Secondary Antibodies

 

Isotype Controls

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Blogs on IFN-beta.

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STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also ...  Read full blog post.
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Bioinformatics

Gene Symbol IFNB1