Binds to human interferon beta with high affinity. For best results in experiments involving neutralization of
the anti-viral effects of human interferon beta we recommend using Sheep Polyclonal Antibody to human interferon beta
(Product 31400-1).
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IFNB1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
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Test in a species/application not listed above to receive a full credit towards a future purchase.
After receipt, the product may be stored at -20°C for short-term use (
≤ 6 months). For
long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the
contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Refreezing
should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers
containing protein such as 0.1% bovine serum albumin (BSA).
Buffer
Phosphate-buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)
Preservative
No Preservative
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for IFN-beta Antibody (MMHB-3) [Unconjugated]
Fibroblast interferon
IFB
IFBIFNB
IFF
IFNB
IFNB1
IFNbeta
IFN-beta
interferon beta
interferon, beta 1, fibroblast
MGC96956
Background
Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
STING in Innate Immunity and Cancer: What’s the Buzz About? STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also ... Read full blog post.
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