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IFN-beta Antibody (MMHB-12) [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Clone
MMHB-12
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

IFN-beta Antibody (MMHB-12) [Unconjugated] Summary

Immunogen
Human interferon beta
Specificity
Detects human interferon beta in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
IFNB1
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Direct ELISA
Application Notes
Due to the variation in ND50 values based on cell type and assay systems, we recommend each user to determine the neutralizing concentration of this lot in their assay system. In an A549/EMCV (cell/virus) assay system, the antibody does not neutralize the cytopathic inhibitory effect of human interferon beta 1a, mammalian. PBL has not tested the use of this product in western blot, flow cytometry, immunoprecipitation or immunohistochemistry.
Publications
Read Publications using
21450-1 in the following applications:

Packaging, Storage & Formulations

Storage
After receipt, the product may be stored at -20°C for short-term use ( ≤ 6 months). For long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).
Buffer
Phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)
Preservative
No Preservative

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-beta Antibody (MMHB-12) [Unconjugated]

  • Fibroblast interferon
  • IFB
  • IFBIFNB
  • IFF
  • IFNB
  • IFNB1
  • IFNbeta
  • IFN-beta
  • interferon beta
  • interferon, beta 1, fibroblast
  • MGC96956

Background

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IFN-beta Antibody (21450-1)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Neutralization.


Filter By Application
Neutralization
(2)
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Filter By Species
Human
(2)
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FAQs for IFN-beta Antibody (21450-1) (0)

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Secondary Antibodies

 

Isotype Controls

Additional IFN-beta Products

Blogs on IFN-beta.

STING in Innate Immunity and Cancer: What’s the Buzz About?
STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also ...  Read full blog post.

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Bioinformatics

Gene Symbol IFNB1