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ICOS Antibody (670306) [Janelia Fluor® 585]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, CyTOF-ready
Clone
670306
Clonality
Monoclonal
Host
Rat
Conjugate
Janelia Fluor 585

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB168U-100UG
Alexa Fluor 405
FAB168V-100UG
Alexa Fluor 488
FAB168G-100UG
Alexa Fluor 532
FAB168X
Alexa Fluor 594
FAB168T-100UG
Alexa Fluor 647
FAB168R-100UG
Alexa Fluor 700
FAB168N-100UG
Alexa Fluor 750
FAB168S-100UG
Allophycocyanin/Cy7
FAB168APCCY7
Biotin
FAB168B
CoraFluor 1
FAB168CL1
DyLight 350
FAB168D
DyLight 405
FAB168E
DyLight 488
FAB168K
DyLight 550
FAB168L
DyLight 594
FAB168M
DyLight 650
FAB168W
DyLight 680
FAB168Y
DyLight 755
FAB168Z
FITC
FAB168F
HRP
FAB168H
Janelia Fluor 525
FAB168JF525
Janelia Fluor 549
FAB168I
Janelia Fluor 635
FAB168JF635
Janelia Fluor 646
FAB168J
Janelia Fluor 669
FAB168JF669
PE/Atto594
FAB168PEATT594
PE/Cy5.5
FAB168PECY55
PE/Cy7
FAB168PECY7
PerCP
FAB168C
Unconjugated
MAB168
mFluor Violet 450 SE
FAB168MFV450
mFluor Violet 500 SE
FAB168MFV500
mFluor Violet 610 SE
FAB168MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB168
Carrier Free
MAB168
Carrier Free
MAB168-SP
Carrier Free
FAB168V-100UG
Carrier Free
FAB168U-100UG
Carrier Free
FAB168T-100UG
Carrier Free
FAB168S-100UG
Carrier Free
FAB168R-100UG
Carrier Free
FAB168N-100UG
Carrier Free
FAB168G-100UG
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ICOS Antibody (670306) [Janelia Fluor® 585] Summary

Immunogen
NS0 mouse myeloma cell line transfected with mouse ICOS
Accession # Q9WVS0
Specificity
Detects mouse ICOS in direct ELISAs.
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
ICOS
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for ICOS Antibody (670306) [Janelia Fluor® 585]

  • Activation-inducible lymphocyte immunomediatory molecule
  • AILIM
  • AILIMCD278
  • CD278 antigen
  • CD278
  • CRP-1
  • CVID1
  • ICOS
  • inducible costimulator
  • inducible T-cell costimulator
  • inducible T-cell co-stimulator
  • MGC39850

Background

The C398.4A antibody reacts with the human, mouse and rat 47-57 kD ICOS protein, also known as inducible costimulatory molecule and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ICOS