Human TSLP Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. The activities of mouse TSLP overlap with, but are distinct from, those of mouse IL-7. Both mouse TSLP and IL-7 can co-stimulate growth of thymocytes and mature T cells, and support B lymphopoiesis in long-term cultures of fetal liver cells and bone-marrow cells. Whereas mouse IL-7 facilitates the development of B220⁺/IgM^- pre-B cells, mouse TSLP promotes the development B220⁺/IgM⁺ B cells. Human TSLP was reported to preferentially stimulate myeloid cells, inducing the release of T cell-attracting chemokines from monocytes and enhancing the maturation of CD11c⁺ dendritic cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence. Within the mature region, six of the seven cysteine residues present in the mouse TSLP involved in intramolecular disulfide bond formation are conserved in the human TSLP. Human TSLP shares approximately 43% aa sequence identity with mouse TSLP. By Northern blot analysis, human TSLP expression has been detected in many tissues with the highest expressions in heart, liver, testis and prostate. TSLP signals through a heterodimeric receptor complex that consists of IL-7 R alpha and the TSLP R, a member of the hemopoietin receptor family most closely related to Rgamma_c.

TSLP R, also named Delta and CRLM-2 (Cytokine Receptor-like Module-2), was originally cloned as a novel type 1 cytokine receptor with similarity to the common gamma chain (gamma c). It was subsequently identified as a subunit of the cellular receptor for the IL-7-like cytokine TSLP and termed TSLP R. TSLP R shows 24% sequence identity with the mouse gc receptor. TSLP R expression is constitutive in immune and hematopoietic cells, but is up-regulated in Th2 cells.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using DTSLP0	Applications	Species
Weng, CM;Lee, MJ;Chao, W;Lin, YR;Chou, CJ;Chen, MC;Chou, CL;Lin Tsai, I;Lin, CH;Fan Chung, K;Kuo, HP; Airway epithelium IgE-Fc?RI Cross-Link Induces Epithelial Barrier Disruption in Severe T2-high Asthma Mucosal immunology 2023-08-01 [PMID: 37536562] (Human)		Human
Z Shen, W Luo, B Tan, K Nie, M Deng, S Wu, M Xiao, X Wu, X Meng, T Tong, C Zhang, K Ma, Y Liao, J Xu, X Wang Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease EBioMedicine, 2022-09-28;85(0):104285. 2022-09-28 [PMID: 36182776] (Human)		Human
SZ Li, XX Jin, XL Ge, YG Zuo, HZ Jin Thymic Stromal Lymphopoietin Is Implicated in the Pathogenesis of Bullous Pemphigoid by Dendritic Cells J Immunol Res, 2020-09-24;2020(0):4594630. 2020-09-24 [PMID: 33029540] (Human)		Human
G Anzalone, GD Albano, AM Montalbano, L Riccobono, A Bonanno, R Gagliardo, F Bucchieri, R Marchese, M Moscato, M Profita IL-17A-associated IKK-? signaling induced TSLP production in epithelial cells of COPD patients Exp. Mol. Med., 2018-10-05;50(10):131. 2018-10-05 [PMID: 30291224] (Human)		Human
HL Yang, KK Chang, J Mei, WJ Zhou, LB Liu, L Yao, Y Meng, MY Wang, SY Ha, ZZ Lai, JF Ye, DJ Li, MQ Li Estrogen restricts the apoptosis of endometrial stromal cells by promoting TSLP secretion Mol Med Rep, 2018-08-24;0(0):. 2018-08-24 [PMID: 30152851]
YA Tyurin, SA Lissovskay, RS Fassahov, IG Mustafin, AF Shamsutdin, MA Shilova, AA Rizvanov Cytokine Profile of Patients with Allergic Rhinitis Caused by Pollen, Mite, and Microbial Allergen Sensitization J Immunol Res, 2017-10-04;2017(0):3054217. 2017-10-04 [PMID: 29109963] (Human)		Human
Wei Zhang Betamethasone Butyrate Propionate Inhibits the Induction of Thymic Stromal Lymphopoietin in Cultured Normal Human Keratinocytes Ann Dermatol, 2016-11-23;28(6):772-775. 2016-11-23 [PMID: 27904282] (Human)		Human
Danso M, van Drongelen V, Mulder A, van Esch J, Scott H, van Smeden J, El Ghalbzouri A, Bouwstra J TNF-alpha and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents. J Invest Dermatol, 2014-02-11;134(7):1941-50. 2014-02-11 [PMID: 24518171] (Human)		Human
Bleck B, Grunig G, Chiu A, Liu M, Gordon T, Kazeros A, Reibman J MicroRNA-375 regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambient particulate matter in human bronchial epithelial cells. J Immunol, 2013-03-01;190(7):3757-63. 2013-03-01 [PMID: 23455502] (Human)		Human
Fontao L, Laffitte E, Briot A, Kaya G, Roux-Lombard P, Fraitag S, Hovnanian AA, Saurat JH Infliximab infusions for netherton syndrome: sustained clinical improvement correlates with a reduction of thymic stromal lymphopoietin levels in the skin. J. Invest. Dermatol., 2011-06-09;131(9):1947-50. 2011-06-09 [PMID: 21654837] (Human)		Human
Semlali A, Jacques E, Koussih L, Gounni AS, Chakir J Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway. J. Allergy Clin. Immunol., 2010-03-17;125(4):844-50. 2010-03-17 [PMID: 20236697] (Human)		Human
Zheng X, Ma P, De Paiva CS, Cunningham MA, Hwang CS, Pflugfelder SC, Li DQ TSLP and downstream molecules in experimental mouse allergic conjunctivitis. Invest. Ophthalmol. Vis. Sci., 2010-01-27;51(6):3076-82. 2010-01-27 [PMID: 20107175] (Human)		Human
Xu G, Zhang L, Wang DY, Xu R, Liu Z, Han DM, Wang XD, Zuo KJ, Li HB Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells. Allergy, 2009-11-25;65(5):581-9. 2009-11-25 [PMID: 19968632] (Human)		Human
Le TA, Takai T, Kinoshita H, Suto H, Ikeda S, Okumura K, Ogawa H Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids. Allergy, 2009-03-27;64(8):1231-2. 2009-03-27 [PMID: 19416141] (Human)		Human
Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines. Invest. Ophthalmol. Vis. Sci., 2009-01-17;50(6):2702-9. 2009-01-17 [PMID: 19151401] (Human)		Human
Versluis M, van den Berge M, Timens W, Luijk B, Rutgers B, Lammers JW, Postma DS, Hylkema MN Allergen inhalation decreases adenosine receptor expression in sputum and blood of asthma patients. Allergy, 2008-09-01;63(9):1186-94. 2008-09-01 [PMID: 18699935] (Human)		Human
Show All 16 Publications. Collapse Publications.

Array DTSLP0

• TSLP Antibodies
• TSLP Kit
• TSLP Lysates
• TSLP Proteins
• TSLP Proteins and Enzymes
• TSLP ELISAs