Human TSLP DuoSet ELISA, 15 Plate

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Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. The activities of mouse TSLP overlap with, but are distinct from, those of mouse IL-7. Both mouse TSLP and IL-7 can co-stimulate growth of thymocytes and mature T cells, and support B lymphopoiesis in long-term cultures of fetal liver cells and bone-marrow cells. Whereas mouse IL-7 facilitates the development of B220⁺/IgM^- pre-B cells, mouse TSLP promotes the development B220⁺/IgM⁺ B cells. Human TSLP was reported to preferentially stimulate myeloid cells, inducing the release of T cell-attracting chemokines from monocytes and enhancing the maturation of CD11c⁺ dendritic cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence. Within the mature region, six of the seven cysteine residues present in the mouse TSLP involved in intramolecular disulfide bond formation are conserved in the human TSLP. Human TSLP shares approximately 43% aa sequence identity with mouse TSLP. By Northern blot analysis, human TSLP expression has been detected in many tissues with the highest expressions in heart, liver, testis and prostate. TSLP signals through a heterodimeric receptor complex that consists of IL-7 R alpha and the TSLP R, a member of the hemopoietin receptor family most closely related to Rgamma_c.

TSLP R, also named Delta and CRLM-2 (Cytokine Receptor-like Module-2), was originally cloned as a novel type 1 cytokine receptor with similarity to the common gamma chain (gamma c). It was subsequently identified as a subunit of the cellular receptor for the IL-7-like cytokine TSLP and termed TSLP R. TSLP R shows 24% sequence identity with the mouse gc receptor. TSLP R expression is constitutive in immune and hematopoietic cells, but is up-regulated in Th2 cells.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 10.

Publications using DY1398	Applications	Species
Yu, H;Zhang, C;Pan, H;Gao, X;Wang, X;Xiao, W;Yan, S;Gao, Y;Fu, J;Zhou, Y; Indeno[1,2,3-cd]pyrene enhances the sensitivity of airway epithelial cells to ferroptosis and aggravates asthma Chemosphere 2024-07-16 [PMID: 39025314] (Mouse)		Mouse
De Monte, L;Clemente, F;Ruggiero, E;Pini, R;Ceraolo, MG;Schiavo Lena, M;Balestrieri, C;Lazarevic, D;Belfiori, G;Crippa, S;Balzano, G;Falconi, M;Doglioni, C;Bonini, C;Reni, M;Protti, MP; Pro-tumor Tfh2 cells induce detrimental IgG4 production and PGE2-dependent IgE inhibition in pancreatic cancer EBioMedicine 2023-09-28 [PMID: 37776595] (Human)		Human
J Kim, K Hegener, C Hagedorn, K Jamal Jame, D Weidinger, IMC Seuthe, S Eichhorn, F Kreppel, J Knobloch, JJ Park Long-Term Cryopreservation of Nasal Polyp Tissue in a Biobank for the Isolation and Culture of Primary Epithelial Cells International Journal of Molecular Sciences, 2023-03-28;24(7):. 2023-03-28 [PMID: 37047354] (Human)		Human
Q Yu, Y Li, H Wang, H Xiong TSLP induces a proinflammatory phenotype in circulating innate cells and predicts prognosis in sepsis patients FEBS Open Bio, 2019-12-01;0(0):. 2019-12-01 [PMID: 31628890] (Human)		Human
K Verstraete, F Peelman, H Braun, J Lopez, D Van Rompae, A Dansercoer, I Vandenberg, K Pauwels, J Tavernier, BN Lambrecht, H Hammad, H De Winter, R Beyaert, G Lippens, SN Savvides Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma Nat Commun, 2017-04-03;8(0):14937. 2017-04-03 [PMID: 28368013] (Human)		Human
Hui C, Yu A, Heroux D, Akhabir L, Sandford A, Neighbour H, Denburg J Thymic stromal lymphopoietin (TSLP) secretion from human nasal epithelium is a function of TSLP genotype. Mucosal Immunol, 2014-12-17;8(5):993-9. 2014-12-17 [PMID: 25515628] (Human)		Human
Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J. Exp. Med., 2012-07-16;209(8):1505-17. 2012-07-16 [PMID: 22802353] (Human)		Human
Okayama Y, Okumura S, Sagara H, Yuki K, Sasaki T, Watanabe N, Fueki M, Sugiyama K, Takeda K, Fukuda T, Saito H, Ra C FcepsilonRI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells. Eur. Respir. J., 2009-01-22;34(2):425-35. 2009-01-22 [PMID: 19164348] (Human)		Human
Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J. Allergy Clin. Immunol., 2008-12-03;123(1):179-86. 2008-12-03 [PMID: 19056108] (Human)		Human
Kato A, Favoreto S, Avila PC, Schleimer RP TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J. Immunol., 2007-07-15;179(2):1080-7. 2007-07-15 [PMID: 17617600] (Human)		Human

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Patricia Carulla Martí			06/22/2023	View Summary Sample Tested Cultured Human Keratinocytes,Supernatant Human Epidermal keratinocytes (HEKa) in presence or absence of Poly(I:C) Lot P305031

Array DY1398

• TSLP Antibodies
• TSLP Kit
• TSLP Lysate
• TSLP Proteins
• TSLP Proteins and Enzymes
• TSLP ELISAs