Human TIMP-2 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using DY971	Applications	Species
Xu, S;Hultström, M;Larsson, A;Lipcsey, M;Lindskog, C;Bülow, S;Frithiof, R;Venge, P; The Human Phospholipase B-II Precursor (HPLBII-P) in Urine as a Novel Biomarker of Glomerular Activity in COVID-19 and Diabetes Mellitus Journal of clinical medicine 2024-04-26 [PMID: 38731071] (Human)		Human
Janev, A;Ramuta, TŽ;Jerman, UD;Obradovi?, H;Kamenšek, U;?emažar, M;Kreft, ME; Human amniotic membrane inhibits migration and invasion of muscle-invasive bladder cancer urothelial cells by downregulating the FAK/PI3K/Akt/mTOR signalling pathway Scientific reports 2023-11-06 [PMID: 37932474] (Human)		Human
Kartasheva-Ebertz D, Gaston J, Lair-Mehiri L, Mottez E, Buivan T, Massault P, Scatton O, Gaujoux S, Vaillant J, Pol S, Lagaye S IL-17A in Human Liver: Significant Source of Inflammation and Trigger of Liver Fibrosis Initiation. Int J Mol Sci, 2022-08-29;23(17):. 2022-08-29 [PMID: 36077175] (Human)		Human
H Huang, Q Lin, X Dai, J Chen, Z Bai, X Li, F Fang, Y Li Derivation and validation of urinary TIMP-1 for the prediction of acute kidney injury and mortality in critically ill children Journal of Translational Medicine, 2022-02-23;20(1):102. 2022-02-23 [PMID: 35197070] (Human)		Human
S Boumiza, K Chahed, Z Tabka, MP Jacob, X Norel, G Ozen MMPs and TIMPs levels are correlated with anthropometric parameters, blood pressure, and endothelial function in obesity Scientific Reports, 2021-10-08;11(1):20052. 2021-10-08 [PMID: 34625635] (Human)		Human
A Abbes, Y Zayani, W Zidi, MB Hammami, A Mebazaa, D El Euch, A Ben Ammar, H Sanhaji, MV El May, M Mokni, M Feki, M Allal-Elas Matrix metalloproteinase-7 could be a predictor for acute inflammation in psoriatic patients Cytokine, 2020-07-11;134(0):155195. 2020-07-11 [PMID: 32663776] (Human)		Human
CC Wu, YR Chen, DH Lu, LH Hsu, KC Yang, S Sumi Evaluation of the post-treatment anti-inflammatory capacity of osteoarthritic chondrocytes: An in�vitro study using baicalein Regen Ther, 2020-02-24;14(0):177-183. 2020-02-24 [PMID: 32128354] (Human)		Human
TT Vuong, SB Rønning, TAE Ahmed, K Brathagen, V Høst, MT Hincke, HP Suso, ME Pedersen Processed eggshell membrane powder regulates cellular functions and increase MMP-activity important in early wound healing processes PLoS ONE, 2018-08-06;13(8):e0201975. 2018-08-06 [PMID: 30080894] (Human)		Human
S Brilha, CWM Ong, B Weksler, N Romero, PO Couraud, JS Friedland Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis Sci Rep, 2017-11-22;7(1):16031. 2017-11-22 [PMID: 29167512] (Human)		Human
CW Ong, PJ Pabisiak, S Brilha, P Singh, F Roncaroli, PT Elkington, JS Friedland Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis J Neuroinflammation, 2017-02-07;14(1):31. 2017-02-07 [PMID: 28173836] (Human)		Human
Rath T, Zwaschka L, Hage L, Kugler M, Menendez K, Naehrlich L, Schulz R, Roderfeld M, Roeb E Identification of neutrophil activation markers as novel surrogate markers of CF lung disease. PLoS ONE, 2014-12-29;9(12):e115847. 2014-12-29 [PMID: 25545245] (Human)		Human
Gomez I, Benyahia C, Louedec L, Leseche G, Jacob M, Longrois D, Norel X Decreased PGE(2) content reduces MMP-1 activity and consequently increases collagen density in human varicose vein. PLoS ONE, 2014-02-05;9(2):e88021. 2014-02-05 [PMID: 24505358]
Tsai HC, Ye SY, Kunin CM, Lee SS, Wann SR, Tai MH, Shi MH, Liu YC, Chen YS Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with HIV-1 infection and syphilis or neurosyphilis. Cytokine, 2011-02-26;54(0):109-16. 2011-02-26 [PMID: 21354815] (Human)		Human
Shyamsundar M, McKeown ST, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am. J. Respir. Crit. Care Med., 2009-03-26;179(12):1107-14. 2009-03-26 [PMID: 19324974] (Human)		Human
Sheen P, O'Kane CM, O'Kane CM, Chaudhary K, Tovar M, Santillan C, Sosa J, Caviedes L, Gilman RH, Stamp G, Friedland JS High MMP-9 activity characterises pleural tuberculosis correlating with granuloma formation. Eur. Respir. J., 2008-08-20;33(1):134-41. 2008-08-20 [PMID: 18715875] (Human)		Human
Dietmann A, Helbok R, Lackner P, Issifou S, Lell B, Matsiegui PB, Reindl M, Schmutzhard E, Kremsner PG Matrix metalloproteinases and their tissue inhibitors (TIMPs) in Plasmodium falciparum malaria: serum levels of TIMP-1 are associated with disease severity. J. Infect. Dis., 2008-06-01;197(11):1614-20. 2008-06-01 [PMID: 18700258] (Human)		Human
Tsai HC, Chung LY, Chen ER, Sy CL Association of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-4 in cerebrospinal fluid with blood-brain barrier dysfunction in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. Am. J. Trop. Med. Hyg., 2008-01-01;78(1):20-7. 2008-01-01 [PMID: 18187780] (Human)		Human
Bergin PJ, Anders E, Sicheng W, Erik J, Jennie A, Hans L, Pierre M, Qiang PH, Marianne QJ Increased production of matrix metalloproteinases in Helicobacter pylori-associated human gastritis. Helicobacter, 2004-06-01;9(0):201. 2004-06-01 [PMID: 15165255] (Human)		Human
Show All 18 Publications. Collapse Publications.

Array DY971

• TIMP-2 Antibodies
• TIMP-2 ELISA Kits
• TIMP-2 Lysate
• TIMP-2 Proteins
• TIMP-2 ELISAs
• TIMP-2 Proteins and Enzymes