Human SCF Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Mature human SCF consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 36 aa cytoplasmic tail. The ECD shows both N-linked and O-linked glycosylation. Proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releases a 25 kDa soluble molecule which is comparable to the only form produced by Steel-dickie mutant mice. An alternately spliced isoform of human SCF lacks 28 aa that encompasses the primary proteolytic recognition site. Within the ECD of the short isoform (corresponding to this recombinant protein), human SCF shares 75 - 83% aa sequence identity with canine, feline, mouse, and rat SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells. Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF-R/c-kit to trigger receptor dimerization and signaling. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels.

We have publications tested in 3 confirmed species: Human, Mouse, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque).

Showing Publications 1 - 10 of 25. Show All 25 Publications. Collapse Publications.

Publications using DCK00	Applications	Species
JC Huang, SC Chen, WA Chang, WW Hung, PH Wu, LY Wu, JM Chang, YL Hsu, YC Tsai KITLG Promotes Glomerular Endothelial Cell Injury in Diabetic Nephropathy by an Autocrine Effect International Journal of Molecular Sciences, 2022-10-03;23(19):. 2022-10-03 [PMID: 36233032] (Human, Mouse)		Human, Mouse
Y Yuan, C Zhou, Q Yang, S Ma, X Wang, X Guo, Y Ding, J Tang, Y Zeng, D Li HIV-1 Tat protein inhibits the hematopoietic support function of human bone marrow mesenchymal stem cells Virus Res., 2019-09-12;273(0):197756. 2019-09-12 [PMID: 31521762] (Human)		Human
T Sun, M Ju, X Dai, H Dong, W Gu, Y Gao, R Fu, X Liu, Y Huang, W Liu, Y Chi, W Wang, H Li, Y Zhou, L Shi, R Yang, L Zhang Multilevel defects in the hematopoietic niche in essential thrombocythemia Haematologica, 2019-07-09;0(0):. 2019-07-09 [PMID: 31289202] (Human)		Human
M Vermeulen, F Del Vento, F de Michele, J Poels, C Wyns Development of a Cytocompatible Scaffold from Pig Immature Testicular Tissue Allowing Human Sertoli Cell Attachment, Proliferation and Functionality Int J Mol Sci, 2018-01-12;19(1):. 2018-01-12 [PMID: 29329231] (Human)		Human
Y Zhang, L He, D Selimoglu-, C Jego, M Morabito, C Willekens, MK Diop, P Gonin, V Lapierre, N Droin, E Solary, F Louache Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines Blood Adv, 2017-06-13;1(14):972-979. 2017-06-13 [PMID: 29296739] (Human)		Human
L Desbourdes, J Javary, T Charbonnie, N Ishac, J Bourgeais, A Iltis, JC Chomel, A Turhan, F Guilloton, K Tarte, MV Demattei, E Ducrocq, F Rouleux-Bo, E Gyan, O Hérault, J Domenech Alteration Analysis of Bone Marrow Mesenchymal Stromal Cells from De Novo Acute Myeloid Leukemia Patients at Diagnosis Stem Cells Dev., 2017-04-10;0(0):. 2017-04-10 [PMID: 28394200] (Human)		Human
E Fischer-Fo, R Mikláš, L Rišia?ová, M Cenariu, IG Grosu, P Virag, MP Schrepler, C Tomuleasa, IB Neagoe, F Devínsky, N Miklášová Novel Palladium(II) Complexes that Influence Prominin-1/CD133 Expression and Stem Cell Factor Release in Tumor Cells Molecules, 2017-03-30;22(4):. 2017-03-30 [PMID: 28358339] (Human)		Human
Abu El-Asrar , Ahmed M, Nawaz , Mohd Imt, Kangave , Dustan, Mairaj Siddiquei , Mohammed, Geboes , Karel Angiogenic and vasculogenic factors in the vitreous from patients with proliferative diabetic retinopathy. J Diabetes Res, 2013-03-10;0(0):539658. 2013-03-10 [PMID: 23671874] (Human)		Human
Harmon CS, DePrimo SE, Raymond E, Cheng AL, Boucher E, Douillard JY, Lim HY, Kim JS, Lechuga MJ, Lanzalone S, Lin X, Faivre S Mechanism-related circulating proteins as biomarkers for clinical outcome in patients with unresectable hepatocellular carcinoma receiving sunitinib. J Transl Med, 2011-07-25;9(0):120. 2011-07-25 [PMID: 21787417] (Human)		Human
Lee JK, Song YS, Shin JS, Kwon YS, Shin MS, Kim JC The change of cytokines in tear and blood after different pterygium operation. Cytokine, 2009-12-08;49(2):148-54. 2009-12-08 [PMID: 20004113] (Human)		Human
Farha S, Asosingh K, Laskowski D, Hammel J, Dweik RA, Wiedemann HP, Erzurum SC Effects of the menstrual cycle on lung function variables in women with asthma. Am. J. Respir. Crit. Care Med., 2009-06-11;180(4):304-10. 2009-06-11 [PMID: 19520904] (Human)		Human
Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, Stingl G, Eppel W, Elbe-Burger A HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells. J. Exp. Med., 2009-01-12;206(1):169-81. 2009-01-12 [PMID: 19139172] (Human)		Human
Westerweel PE, Visseren FL, Hajer GR, Olijhoek JK, Hoefer IE, de Bree P, Rafii S, Doevendans PA, Verhaar MC Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy. Eur. Heart J., 2008-09-28;29(22):2808-17. 2008-09-28 [PMID: 18824462] (Human)		Human
Hollins F, Kaur D, Yang W, Cruse G, Saunders R, Sutcliffe A, Berger P, Ito A, Brightling CE, Bradding P Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J. Immunol., 2008-08-15;181(4):2772-80. 2008-08-15 [PMID: 18684968] (Human)		Human
Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp. Hematol., 2008-05-27;36(8):1035-46. 2008-05-27 [PMID: 18504067] (Human)		Human
Han ZB, Ren H, Zhao H, Chi Y, Chen K, Zhou B, Liu YJ, Zhang L, Xu B, Liu B, Yang R, Han ZC Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF). Carcinogenesis, 2008-03-13;29(10):1853-61. 2008-03-13 [PMID: 18339685] (Human)		Human
Makowska JS, Grzegorczyk J, Bienkiewicz B, Wozniak M, Kowalski ML Systemic responses after bronchial aspirin challenge in sensitive patients with asthma. J. Allergy Clin. Immunol., 2007-12-20;121(2):348-54. 2007-12-20 [PMID: 18086495] (Human)		Human
Dentelli P, Rosso A, Balsamo A, Colmenares Benedetto S, Zeoli A, Pegoraro M, Camussi G, Pegoraro L, Brizzi MF C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium. Blood, 2007-02-08;109(10):4264-71. 2007-02-08 [PMID: 17289809] (Human)		Human
Hatfield K, Ryningen A, Corbascio M, Bruserud O Microvascular endothelial cells increase proliferation and inhibit apoptosis of native human acute myelogenous leukemia blasts. Int. J. Cancer, 2006-11-15;119(10):2313-21. 2006-11-15 [PMID: 16921487] (Human)		Human
Drouet M, Mourcin F, Grenier N, Leroux V, Denis J, Mayol JF, Thullier P, Lataillade JJ, Herodin F Single administration of stem cell factor, FLT-3 ligand, megakaryocyte growth and development factor, and interleukin-3 in combination soon after irradiation prevents nonhuman primates from myelosuppression: long-term follow-up of hematopoiesis. Blood, 2003-10-02;103(3):878-85. 2003-10-02 [PMID: 14525791] (Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque))		Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Lamming CE, 175, Augustin L, Blackstad M, Lund TC, Hebbel RP, Verfaillie CM Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisis. 2003-03-01;111(6):811-9. 2003-03-01 [PMID: 12639987] (Human)		Human
Briard D, Brouty-Boye D, Azzarone B, Jasmin C Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15. J. Immunol., 2002-05-01;168(9):4326-32. 2002-05-01 [PMID: 11970974] (Human)		Human
Bovolenta C, Pilotti E, Mauri M, Turci M, Ciancianaini P, Fisicaro P, Bertazzoni U, Poli G, Casoli C Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor. Blood, 2002-01-01;99(1):224-31. 2002-01-01 [PMID: 11756175] (Human)		Human
Hartman M, Piliponsky AM, Temkin V Human peripheral blood eosinophils express stem cell factor. Blood, 2001-02-15;97(4):1086-91. 2001-02-15 [PMID: 11159541] (Human)		Human
Osuga Y, Koga K, Tsutsumi O, Igarashi T, Okagaki R, Takai Y, Matsumi H, Hiroi H, Fujiwara T, Momoeda M, Yano T, Taketani Y Stem cell factor (SCF) concentrations in peritoneal fluid of women with or without endometriosis. Am. J. Reprod. Immunol., 2000-10-01;44(4):231-5. 2000-10-01 [PMID: 11076095] (Human)		Human
Show All 25 Publications. Collapse Publications.

Array DCK00

• SCF/c-kit Ligand Antibodies
• SCF/c-kit Ligand ELISA Kits
• SCF/c-kit Ligand Lysate
• SCF/c-kit Ligand Proteins
• SCF/c-kit Ligand Proteins and Enzymes
• SCF/c-kit Ligand ELISAs