Human SCF DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein. It promotes the survival, differentiation, and mobilization of multiple cell types including myeloid, erythroid, megakaryocytic, lymphoid, germ cell, and melanocyte progenitors. SCF is a primary growth and activation factor for mast cells and eosinophils. Mature human SCF consists of a 189 amino acid (aa) extracellular domain (ECD), a 23 aa transmembrane segment, and a 36 aa cytoplasmic tail. The ECD shows both N-linked and O-linked glycosylation. Proteolytic cleavage at two alternate sites in the extracellular juxtamembrane region releases a 25 kDa soluble molecule which is comparable to the only form produced by Steel-dickie mutant mice. An alternately spliced isoform of human SCF lacks 28 aa that encompasses the primary proteolytic recognition site. Within the ECD of the short isoform (corresponding to this recombinant protein), human SCF shares 75 - 83% aa sequence identity with canine, feline, mouse, and rat SCF. Rat SCF is active on mouse and human cells, but human SCF is only weakly active on mouse cells. Noncovalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF-R/c-kit to trigger receptor dimerization and signaling. SCF assists in the recovery of cardiac function following myocardial infarction by increasing the number of cardiomyocytes and vascular channels.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 3 of 3.

Publications using DY255	Applications	Species
Alehagen, U;Alexander, J;Aaseth, JO;Larsson, A;Svensson, E;Opstad, TB; Effects of an Intervention with Selenium and Coenzyme Q10 on Five Selected Age-Related Biomarkers in Elderly Swedes Low in Selenium: Results That Point to an Anti-Ageing Effect-A Sub-Analysis of a Previous Prospective Double-Blind Placebo-Controlled Randomised Clinical Trial Cells 2023-07-04 [PMID: 37443807] (Human)		Human
P Peterlin, J Gaschet, T Guillaume, A Garnier, M Eveillard, A Le Bourgeo, M Cherel, C Debord, Y Le Bris, O Theisen, C Godon, B Mahé, V Dubruille, S Wuilleme, C Touzeau, T Gastinne, N Blin, A Lok, B Tessoulin, S Le Gouill, P Moreau, MC Béné, P Chevallier A new cytokine-based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia Cancer Medicine, 2020-12-25;0(0):. 2020-12-25 [PMID: 33369136] (Human)		Human
Carlsson A, Larsson T, Helmersson-Karlqvist J, Larsson A, Lind L, Arnlov J Soluble TNF receptors and kidney dysfunction in the elderly. J Am Soc Nephrol, 2014-02-07;25(6):1313-20. 2014-02-07 [PMID: 24511129] (Human)		Human

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Patricia Carulla Martí			06/28/2023	View Summary Sample Tested Human foreskin, adult ski, engineered human skin, keratinocytes, HaCaT cells,Supernatant from cultured human keratinocyte cell line (HaCat) Lot 1369075

Array DY255

• SCF/c-kit Ligand Antibodies
• SCF/c-kit Ligand ELISA Kits
• SCF/c-kit Ligand Lysate
• SCF/c-kit Ligand Proteins
• SCF/c-kit Ligand ELISAs
• SCF/c-kit Ligand Proteins and Enzymes