Human Phospho-Insulin R DuoSet IC ELISA, 2 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Insulin Receptor (INSR, CD220) is a type I transmembrane glycoprotein in the Insulin/IGF Receptor family of receptor tyrosine kinases. The mature receptor contains an extracellular alpha subunit and an extracellular/transmembrane/cytoplasmic beta subunit. Alternative splicing generates A and B isoforms which may homodimerize or heterodimerize with the IGF-I receptor. All receptor combinations bind Insulin, IGF-I, or IGF-II, but with differing affinities. Insulin R signaling regulates glucose uptake and metabolism but also contributes to cell growth, differentiation and apoptosis. Mutations in INSR have been linked to severe insulin resistance (type A and Rabson-Mendenhall syndrome), type II diabetes mellitus, and leprechaunism (Donohue syndrome).

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 3 of 3.

Publications using DYC2718-2	Applications	Species
Lo , Hsin-Yi, Hsiang , Chien-Yu, Li , Tsai-Chu, Li , Chia-Che, Huang , Hui-Chi, Chen , Jaw-Chyu, Ho , Tin-Yun A novel glycated hemoglobin A1c-lowering traditional Chinese medicinal formula, identified by translational medicine study. PLoS ONE, 2014-08-18;9(8):e104650. 2014-08-18 [PMID: 25133699] (Human)		Human
Brouwer-Visser , Jurriaan, Lee , Jiyeon, McCullagh , KellyAnn, Cossio , Maria J, Wang , Yanhua, Huang , Gloria S Insulin-like growth factor 2 silencing restores taxol sensitivity in drug resistant ovarian cancer. PLoS ONE, 2014-06-16;9(6):e100165. 2014-06-16 [PMID: 24932685] (Human)		Human
Weichhaus M, Broom J, Wahle K, Bermano G A novel role for insulin resistance in the connection between obesity and postmenopausal breast cancer. Int. J. Oncol., 2012-05-16;41(2):745-52. 2012-05-16 [PMID: 22614942] (Human)		Human

Array DYC2718-2

• Insulin R/CD220 Antibodies
• Insulin R/CD220 ELISA Kits
• Insulin R/CD220 Protein
• Insulin R/CD220 Proteins and Enzymes
• Insulin R/CD220 ELISAs