Human LIF Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Based on its helical structure, LIF (Leukemia Inhibitory Factor) is considered a member of the Interleukin-6 family of cytokines. Functionally, it has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. Some cell types known to express LIF include activated T cells, monocytes, astrocytes, osteoblasts, keratinocytes, regenerating skeletal muscle, mast cells, and fibroblasts. The activities of LIF are mediated through a high-affinity heterodimeric receptor complex consisting of two membrane glycoproteins: an alpha subunit (LIF R alpha, also known as LIF R beta and CD118) that binds LIF with low affinity and the 130 kDa (gp130) subunit that does not bind LIF by itself, but is required for high-affinity binding of LIF by the complex.

We have publications tested in 2 confirmed species: Human, Primate - Chlorocebus aethiops (African Green Monkey).

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using DLF00B	Applications	Species
S Xu, X Yang, Q Chen, Z Liu, Y Chen, X Yao, A Xiao, J Tian, L Xie, M Zhou, Z Hu, F Zhu, X Xu, F Hou, J Nie Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis EBioMedicine, 2022-11-04;86(0):104312. 2022-11-04 [PMID: 36335669] (Human)		Human
H Li, J Yao, X Chang, J Wu, T Duan, K Wang LIFR increases the release of sEng via the up-regulation of MMP14 expression in PE Reproduction, 2018-01-23;0(0):. 2018-01-23 [PMID: 29363569] (Human)		Human
da Costa SV, Roela RA, Junqueira MS, Arantes C, Brentani MM The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes. Leuk. Res., 2009-11-14;34(4):507-12. 2009-11-14 [PMID: 19913910] (Human)		Human
Xiao Y, Sun X, Yang X, Zhang J, Xue Q, Cai B, Zhou Y Leukemia inhibitory factor is dysregulated in the endometrium and uterine flushing fluid of patients with adenomyosis during implantation window. Fertil. Steril., 2009-04-09;94(1):85-9. 2009-04-09 [PMID: 19361790] (Human)		Human
Evans J, Catalano RD, Brown P, Sherwin R, Critchley HO, Fazleabas AT, Jabbour HN Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor. FASEB J., 2009-03-02;23(7):2165-75. 2009-03-02 [PMID: 19255255] (Human)		Human
Bronte-Tinkew DM, Terebiznik M, Franco A, Ang M, Ahn D, Mimuro H, Sasakawa C, Ropeleski MJ, Peek RM, Jones NL Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. Cancer Res., 2009-01-15;69(2):632-9. 2009-01-15 [PMID: 19147578] (Human)		Human
Xu JW, Yasui N, Ikeda K, Pan WJ, Watanabe J, Shiotani M, Yanaihara A, Miki T, Yamori Y Isoflavones regulate secretion of leukemia inhibitory factor and transforming growth factor {beta} and expression of glycodelin in human endometrial epithelial cells. J. Endocrinol., 2008-02-01;196(2):425-33. 2008-02-01 [PMID: 18252965] (Human)		Human
Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, Preisser L, Anegon I, Catala L, Ifrah N, Descamps P, Gamelin E, Gascan H, Hebbar M, Jeannin P Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood, 2007-09-11;110(13):4319-30. 2007-09-11 [PMID: 17848619] (Human)		Human
Kamohara H, Ogawa M, Ishiko T, Sakamoto K, Baba H Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression. Int. J. Oncol., 2007-04-01;30(4):977-83. 2007-04-01 [PMID: 17332938] (Human)		Human
Zhang Y, Taveggia C, Melendez-Vasquez C, Einheber S, Raine CS, Salzer JL, Brosnan CF, John GR Interleukin-11 potentiates oligodendrocyte survival and maturation, and myelin formation. J. Neurosci., 2006-11-22;26(47):12174-85. 2006-11-22 [PMID: 17122042] (Human)		Human
Wunder DM, Mueller MD, Birkhauser MH, Bersinger NA Increased ENA-78 in the follicular fluid of patients with endometriosis. Acta Obstet Gynecol Scand, 2006-01-01;85(3):336-42. 2006-01-01 [PMID: 16553183] (Human)		Human
Hirota H, Izumi M, Hamaguchi T, Sugiyama S, Murakami E, Kunisada K, Fujio Y, Oshima Y, Nakaoka Y, Yamauchi-Takihara K Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure. Heart Vessels, 2004-09-01;19(5):237-41. 2004-09-01 [PMID: 15372299] (Human)		Human
Lopez-Karpovitch X, Barrales-Benitez O, Flores M, Piedras J Effect of azacytidine in the release of leukemia inhibitory factor, oncostatin m, interleukin (IL)-6, and IL-11 by mononuclear cells of patients with refractory anemia. Cytokine, 2002-11-24;20(4):154-62. 2002-11-24 [PMID: 12543079] (Human)		Human
Nakao T, Kim S, Ohta K, Kawano H, Hino M, Miura K, Tatsumi N, Iwao H Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. Br. J. Pharmacol., 2002-08-01;136(7):975-84. 2002-08-01 [PMID: 12145097] (Human)		Human
Chen CD, Yang JH, Lin KC, Chao KH, Ho HN, Yang YS The significance of cytokines, chemical composition, and murine embryo development in hydrosalpinx fluid for predicting the IVF outcome in women with hydrosalpinx. Hum. Reprod., 2002-01-01;17(1):128-33. 2002-01-01 [PMID: 11756375] (Human)		Human
Rockman SP, 5/½µÚ%«Û, Demmler K, Roczo N, Cosgriff A, Phillips WA, Thomas RJ, Whitehead RH Expression of interleukin-6, leukemia inhibitory factor and their receptors by colonic epithelium and pericryptal fibroblasts. 2001-09-01;16(9):991-1000. 2001-09-01 [PMID: 11595063] (Human)		Human
Carstanjen D, Regenfus M, Muller C, Salama A Interleukin-6 is a major effector molecule of short-term G-CSF treatment inducing bone metabolism and an acute-phase response. Exp. Hematol., 2001-07-01;29(7):812-21. 2001-07-01 [PMID: 11438203] (Human)		Human
Loeuillet C, Bernard G, Remy-Martin J, Saas P, Herve P, Douay L, Chalmers D Distinct hematopoietic support by two human stromal cell lines. Exp. Hematol., 2001-06-01;29(6):736-45. 2001-06-01 [PMID: 11378269] (Human)		Human
Carnegie JA, Morgan JJ, McDiarmid N, Durnford R Influence of protein supplements on the secretion of leukaemia inhibitory factor by mitomycin-pretreated Vero cells: possible application to the in vitro production of bovine blastocysts with high cryotolerance. J. Reprod. Fertil., 1999-09-01;117(1):41-8. 1999-09-01 [PMID: 10645244] (Primate - Chlorocebus aethiops (African Green Monkey))		Primate - Chlorocebus aethiops (African Green Monkey)
Show All 19 Publications. Collapse Publications.

Array DLF00B

• LIF Antibodies
• LIF ELISA Kit
• LIF Lysate
• LIF Proteins
• LIF Proteins and Enzymes
• LIF ELISAs