Human Jagged 1 DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Mammalian Jagged proteins are homologs of the Drosophila Notch ligand, Serrate, and together with Delta-like proteins, constitute ligands for the mammalian Notch proteins. Jagged 1 and 2 are 180 kDa and 150 kDa type I transmembrane glycoproteins, respectively, that possess extracellular DSL (delta, serrate, lag-2 consensus sequence) domains necessary for binding to Notch receptors, along with 15-16 calcium-binding EGF-like repeats which modulate the binding affinity. Jagged-Notch signaling specifies cell fate, regulates pattern formation, defines boundaries between different cell types, and modulates cell proliferation and differentiation, especially during hematopoiesis, myogenesis, neurogenesis and development of the vasculature. Since both the ligands and receptors are transmembrane proteins, direct cell-cell interactions are thought to be required for functional Notch signaling.

We have publications tested in 1 confirmed species: Human.

Showing Publication 1 - 1 of 1.

Publication using DY1277-05	Applications	Species
H Kim, B Jang, YJ Kim, JC Choi Determination of Blood NOTCH3 Extracellular Domain and Jagged-1 Levels in Healthy Subjects International Journal of Molecular Sciences, 2022-09-11;23(18):. 2022-09-11 [PMID: 36142458] (Human)		Human

Array DY1277-05

• Jagged 1 Antibodies
• Jagged 1 ELISA Kit
• Jagged 1 Lysate
• Jagged 1 Protein
• Jagged 1 ELISAs
• Jagged 1 Proteins and Enzymes