Human IL-6R alpha Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-6 R alpha is a transmembrane subunit of the receptor for Interleukin-6. It associates with gp130 which is a shared component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. IL-6 plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis.

We have publications tested in 3 confirmed species: Human, Rat, Primate - Macaca mulatta (Rhesus Macaque).

Showing Publications 1 - 10 of 45. Show All 45 Publications. Collapse Publications.

Publications using DR600	Applications	Species
Odell, ID;Agrawal, K;Sefik, E;Odell, AV;Caves, E;Kirkiles-Smith, NC;Horsley, V;Hinchcliff, M;Pober, JS;Kluger, Y;Flavell, RA; IL-6 trans-signaling in a humanized mouse model of scleroderma Proceedings of the National Academy of Sciences of the United States of America 2023-09-12 [PMID: 37669366] (Human)		Human
V Bratseth, J Nordeng, R Helseth, S Solheim, S Åkra, H Arnesen, G Chiva-Blan, I Seljeflot Circulating Microvesicles in Association with the NLRP3 Inflammasome in Coronary Thrombi from STEMI Patients Biomedicines, 2022-09-05;10(9):. 2022-09-05 [PMID: 36140297] (Human)		Human
J Baran, ? Niewiara, J Podolec, M Siedli?ski, E Józefczuk, A Bernacik, R Badacz, T Przew?ocki, P Pieni??ek, K ?mudka, J Legutko, A Kab?ak-Zie Serum and Vascular Stiffness Biomarkers Associated with the Severity of Degenerative Aortic Valve Stenosis and Cardiovascular Outcomes Oncogene, 2022-06-17;9(6):. 2022-06-17 [PMID: 35735822] (Human)		Human
S Siamakpour, F Cao, J Lyu, Y Ren, AB Nixon, J Xie, AT Bush, MD Starr, JR Bain, MJ Muehlbauer, O Ilkayeva, V Byers Krau, JL Huebner, NJ Chao, AD Sung Evaluating immune response and metabolic related biomarkers pre-allogenic hematopoietic stem cell transplant in acute myeloid leukemia PLoS ONE, 2022-06-14;17(6):e0268963. 2022-06-14 [PMID: 35700185] (Human)		Human
R Salemi, G Gattuso, B Tomasello, A Lavoro, A Gaudio, M Libra, SS Signorelli, S Candido Co-Occurrence of Interleukin-6 Receptor Asp358Ala Variant and High Plasma Levels of IL-6: An Evidence of IL-6 Trans-Signaling Activation in Deep Vein Thrombosis (DVT) Patients Biomolecules, 2022-05-10;12(5):. 2022-05-10 [PMID: 35625609] (Human)		Human
L Suo, M Wang Dexmedetomidine attenuates oxygen-glucose deprivation/ reperfusion-induced inflammation through the miR-17-5p/ TLR4/ NF-kappaB axis BMC anesthesiology, 2022-04-29;22(1):126. 2022-04-29 [PMID: 35488217] (Rat)		Rat
CD Ene, SR Georgescu, M Tampa, C Matei, CI Mitran, MI Mitran, MN Penescu, I Nicolae Cellular Response against Oxidative Stress, a Novel Insight into Lupus Nephritis Pathogenesis Journal of personalized medicine, 2021-07-22;11(8):. 2021-07-22 [PMID: 34442337] (Human)		Human
J Nordeng, H Schandiz, S Solheim, S Åkra, P Hoffman, B Roald, B Bendz, H Arnesen, R Helseth, I Seljeflot The Inflammasome Signaling Pathway Is Actively Regulated and Related to Myocardial Damage in Coronary Thrombi from Patients with STEMI Mediators of Inflammation, 2021-05-27;2021(0):5525917. 2021-05-27 [PMID: 34135690] (Human)		Human
CD Ene, MN Penescu, SR Georgescu, M Tampa, I Nicolae Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma Metabolites, 2020-12-27;11(1):. 2020-12-27 [PMID: 33375435] (Human)		Human
KP Loh, JA Tooze, BJ Nicklas, SB Kritchevsk, JD Williamson, LR Ellis, BL Powell, TS Pardee, NG Goyal, HD Klepin Inflammatory biomarkers, geriatric assessment, and treatment outcomes in acute myeloid leukemia J Geriatr Oncol, 2019-04-05;0(0):. 2019-04-05 [PMID: 30962090] (Human)		Human
S Ishikawa, M Tasaki, T Kuroda, D Kobayashi, K Saito, Y Nakagawa, M Ikeda, K Takahashi, Y Tomita Management of Juvenile Idiopathic Arthritis in ABO-incompatible Kidney Transplantation: A Case Report Transplant. Proc., 2018-04-01;50(3):869-872. 2018-04-01 [PMID: 29661455] (Human)		Human
H Munir, LS Ward, L Sheriff, S Kemble, S Nayar, F Barone, GB Nash, HM McGettrick Adipogenic differentiation of MSC alters their immunomodulatory properties in a tissue-specific manner Stem Cells, 2017-04-24;0(0):. 2017-04-24 [PMID: 28376564] (Human)		Human
Koji Osuka Inhibitory Mechanism of the Outer Membrane Growth of Chronic Subdural Hematomas J. Neurotrauma, 2017-02-27;0(0):. 2017-02-27 [PMID: 28027695] (Human)		Human
Prevalent peripheral arterial disease and inflammatory burden BMC Geriatr, 2016-12-09;16(1):213. 2016-12-09 [PMID: 27938334] (Human)		Human
IL-6 trans-signaling is another pathway to upregulate Osteopontin Cytokine, 2016-11-15;90(0):88-95. 2016-11-15 [PMID: 27863335] (Human)		Human
Inflammatory Markers and the Risk of Hip and Vertebral Fractures in Men: the Osteoporotic Fractures in Men (MrOS) J Bone Miner Res, 2016-07-25;0(0):. 2016-07-25 [PMID: 27371811] (Human)		Human
P Srikanth, R F Chun, M Hewison, J S Adams, R Bouillon, D Vandersch, N Lane, P M Cawthon, T Dam, E Barrett-C, L B Daniels, J M Shikany, M L Stefanick, J A Cauley, E S Orwoll, C M Nielson Associations of total and free 25OHD and 1,25(OH)2D with serum markers of inflammation in older men. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the Usa, 2016-02-23;0(0):1433-2965. 2016-02-23 [PMID: 26905270] (Human)		Human
Zhong H, Davis A, Ouzounova M, Carrasco R, Chen C, Breen S, Chang Y, Huang J, Liu Z, Yao Y, Hurt E, Moisan J, Fung M, Tice D, Clouthier S, Xiao Z, Wicha M, Korkaya H, Hollingsworth R A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors. Cancer Res, 2016-01-07;76(2):480-90. 2016-01-07 [PMID: 26744529] (Human)		Human
Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFalpha-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. PLoS ONE, 2015-03-18;10(3):e0119415. 2015-03-18 [PMID: 25785838] (Human)		Human
Csaszar , Elizabet, Wang , Weijia, Usenko , Tatiana, Qiao , Wenlian, Delaney , Colleen, Bernstein , Irwin D, Zandstra , Peter W Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling. Blood, 2013-11-15;123(5):650-8. 2013-11-15 [PMID: 24243972] (Human)		Human
Salsano , Ettore, Rizzo , Ambra, Bedini , Gloria, Bernard , Loris, Dall'olio , Valentin, Volorio , Sara, Lazzaroni , Monica, Ceccherini , Isabella, Lazarevic , Dejan, Cittaro , Davide, Stupka , Elia, Paterra , Rosina, Farina , Laura, Savoiardo , Mario, Pareyson , Davide, Sciacca , Francesc An autoinflammatory neurological disease due to interleukin 6 hypersecretion. J Neuroinflammation, 2013-02-21;10(0):29. 2013-02-21 [PMID: 23432807] (Human)		Human
Tai Y, Chang B, Kong S, Fulciniti M, Yang G, Calle Y, Hu Y, Lin J, Zhao J, Cagnetta A, Cea M, Sellitto M, Zhong M, Wang Q, Acharya C, Carrasco D, Buggy J, Elias L, Treon S, Matsui W, Richardson P, Munshi N, Anderson K Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma. Blood, 2012-06-11;120(9):1877-87. 2012-06-11 [PMID: 22689860] (Human)		Human
Barbour KE, Boudreau R, Danielson ME, Youk AO, Wactawski-Wende J, Greep NC, LaCroix AZ, Jackson RD, Wallace RB, Bauer DC, Allison MA, Cauley JA Inflammatory markers and the risk of hip fracture: the Women's Health Initiative. J. Bone Miner. Res., 2012-05-01;27(5):1167-76. 2012-05-01 [PMID: 22392817] (Human)		Human
Holmlund U, Amoudruz P, Johansson MA, Haileselassie Y, Ongoiba A, Kayentao K, Traore B, Doumbo S, Schollin J, Doumbo O, Montgomery SM, Sverremark-Ekstrom E Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring. Clin. Exp. Immunol., 2010-10-05;162(3):500-9. 2010-10-05 [PMID: 20942805] (Human)		Human
Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria. Transplantation, 2009-11-15;88(9):1109-16. 2009-11-15 [PMID: 19898207] (Human)		Human
Chauhan D, Singh AV, Brahmandam M, Carrasco R, Bandi M, Hideshima T, Bianchi G, Podar K, Tai YT, Mitsiades C, Raje N, Jaye DL, Kumar SK, Richardson P, Munshi N, Anderson KC Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target. Cancer Cell, 2009-10-06;16(4):309-23. 2009-10-06 [PMID: 19800576] (Human)		Human
Fuligni AJ, Telzer EH, Bower J, Irwin MR, Kiang L, Cole SW Daily family assistance and inflammation among adolescents from Latin American and European backgrounds. Brain Behav. Immun., 2009-03-09;23(6):803-9. 2009-03-09 [PMID: 19275931] (Human)		Human
Ara T, Song L, Shimada H, Keshelava N, Russell HV, Metelitsa LS, Groshen SG, Seeger RC, DeClerck YA Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. Cancer Res., 2009-01-01;69(1):329-37. 2009-01-01 [PMID: 19118018] (Human)		Human
Perez-Andres M, Almeida J, Martin-Ayuso M, De Las Heras N, Moro MJ, Martin-Nunez G, Galende J, Cuello R, Abuin I, Moreno I, Dominguez M, Hernandez J, Mateo G, San Miguel JF, Orfao A Soluble and membrane levels of molecules involved in the interaction between clonal plasma cells and the immunological microenvironment in multiple myeloma and their association with the characteristics of the disease. Int. J. Cancer, 2009-01-15;124(2):367-75. 2009-01-15 [PMID: 19003959] (Human)		Human
Egler RA, Burlingame SM, Nuchtern JG, Russell HV Interleukin-6 and soluble interleukin-6 receptor levels as markers of disease extent and prognosis in neuroblastoma. Clin. Cancer Res., 2008-11-01;14(21):7028-34. 2008-11-01 [PMID: 18980999] (Human)		Human
Shariat SF, Karam JA, Walz J, Roehrborn CG, Montorsi F, Margulis V, Saad F, Slawin KM, Karakiewicz PI Improved prediction of disease relapse after radical prostatectomy through a panel of preoperative blood-based biomarkers. Clin. Cancer Res., 2008-06-15;14(12):3785-91. 2008-06-15 [PMID: 18559597] (Human)		Human
Sadeghi M, Susal C, Daniel V, Naujokat C, Zimmermann R, Huth-Kuhne A, Opelz G Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapy. AIDS Res. Hum. Retroviruses, 2007-07-01;23(7):886-90. 2007-07-01 [PMID: 17678471] (Human)		Human
Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, Jones SA, Rose-John S, Scheller J Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood, 2007-06-13;110(6):1748-55. 2007-06-13 [PMID: 17567983] (Human)		Human
Cauley JA, Danielson ME, Boudreau RM, Forrest KY, Zmuda JM, Pahor M, Tylavsky FA, Cummings SR, Harris TB, Newman AB Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study. J. Bone Miner. Res., 2007-07-01;22(7):1088-95. 2007-07-01 [PMID: 17419681] (Human)		Human
Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, Jones SA Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum., 2006-05-01;54(5):1662-72. 2006-05-01 [PMID: 16646038] (Human)		Human
Tsai MY, Hanson NQ, Straka RJ, Hoke TR, Ordovas JM, Peacock JM, Arends VL, Arnett DK Effect of influenza vaccine on markers of inflammation and lipid profile. J. Lab. Clin. Med., 2005-06-01;145(6):323-7. 2005-06-01 [PMID: 15976761] (Human)		Human
Kaneyama K, Segami N, Sun W, Sato J, Fujimura K Levels of soluble cytokine factors in temporomandibular joint effusions seen on magnetic resonance images. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005-04-01;99(4):411-8. 2005-04-01 [PMID: 15772591] (Human)		Human
Sadeghi M, Daniel V, Naujokat C, Wiesel M, Hergesell O, Opelz G Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infection. Transpl. Int., 2005-02-01;18(2):177-85. 2005-02-01 [PMID: 15691270] (Human)		Human
Hirota H, Izumi M, Hamaguchi T, Sugiyama S, Murakami E, Kunisada K, Fujio Y, Oshima Y, Nakaoka Y, Yamauchi-Takihara K Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure. Heart Vessels, 2004-09-01;19(5):237-41. 2004-09-01 [PMID: 15372299] (Human)		Human
Petrucci MT, Ricciardi MR, Gregorj C, Ciapponi L, Savino R, Ciliberto G, Tafuri A Effects of IL-6 variants in multiple myeloma: growth inhibition and induction of apoptosis in primary cells. Leuk. Lymphoma, 2002-12-01;43(12):2369-75. 2002-12-01 [PMID: 12613526] (Human)		Human
Lukashevich IS, Tikhonov I, Rodas JD, Zapata JC, Yang Y, Djavani M, Salvato MS Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation. J. Virol., 2003-02-01;77(3):1727-37. 2003-02-01 [PMID: 12525606] (Primate - Macaca mulatta (Rhesus Macaque))		Primate - Macaca mulatta (Rhesus Macaque)
Carstanjen D, Regenfus M, Muller C, Salama A Interleukin-6 is a major effector molecule of short-term G-CSF treatment inducing bone metabolism and an acute-phase response. Exp. Hematol., 2001-07-01;29(7):812-21. 2001-07-01 [PMID: 11438203] (Human)		Human
Keller ET, 49536, Binkley NC, Stebler BA, Hall DM, Johnston GM, Zhang J, Ershler WB Ovariectomy does not induce osteopenia through interleukin-6 in rhesus monkeys (Macaca mulatta). CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis, 2000-01-01;26(1):55-62. 2000-01-01 [PMID: 10617157] (Primate - Macaca mulatta (Rhesus Macaque))		Primate - Macaca mulatta (Rhesus Macaque)
Hampel H, Teipel SJ, Padberg F, Haslinger A, Riemenschneider M, Schwarz MJ, Kotter HU, Scheloske M, Buch K, Stubner S, Dukoff R, Lasser R, Moller N, Sunderland T, Rapoport SI, Moller HJ Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease. Brain Res., 1999-03-27;823(1):104-12. 1999-03-27 [PMID: 10095017] (Human)		Human
Stubner S, Schon T, Padberg F, Teipel SJ, Schwarz MJ, Haslinger A, Buch K, Dukoff R, Lasser R, Moller N, Sunderland T, Rapoport SI, Moller HJ, Hampel H Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression: no alteration of soluble gp130. Neurosci. Lett., 1999-01-15;259(3):145-8. 1999-01-15 [PMID: 10025579] (Human)		Human
Show All 45 Publications. Collapse Publications.

Array DR600

• IL-6R alpha Antibodies
• IL-6R alpha Antibody Pair
• IL-6R alpha ELISA Kit
• IL-6R alpha Proteins and Enzymes
• IL-6R alpha ELISAs