Human IL-4 DuoSet ELISA, 15 Plate

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IL-4 (Interleukin-4) is a cytokine that is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. The type I receptor for IL-4, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R? and the common ? chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and -21). The type II receptor on nonhematopoietic cells consists of IL-4 R? and IL-13 R?1. The type II receptor also transduces IL-13 mediated signals.

We have publications tested in 3 confirmed species: Human, Mouse, Primate - Presbytis entellus (Indian langur).

Showing Publications 1 - 10 of 48. Show All 48 Publications. Collapse Publications.

Publications using DY204	Applications	Species
Katsoulis, O;Toussaint, M;Jackson, MM;Mallia, P;Footitt, J;Mincham, KT;Meyer, GFM;Kebadze, T;Gilmour, A;Long, M;Aswani, AD;Snelgrove, RJ;Johnston, SL;Chalmers, JD;Singanayagam, A; Neutrophil extracellular traps promote immunopathogenesis of virus-induced COPD exacerbations Nature communications 2024-07-09 [PMID: 38982052] (Human)		Human
Chen, KY;Sun, WL;Wu, SM;Feng, PH;Lin, CF;Chen, TT;Lu, YH;Ho, SC;Chen, YH;Lee, KY; Reduced Tolerogenic Program Death-Ligand 1-Expressing Conventional Type 1 Dendritic Cells Are Associated with Rapid Decline in Chronic Obstructive Pulmonary Disease Cells 2024-05-20 [PMID: 38786101] (Human)		Human
da Costa Teixeira, LA;Soares, LA;Lima, LP;Avelar, NCP;de Moura, JA;Leopoldino, AAO;Figueiredo, PHS;Parentoni, AN;Mendonça, VA;Lacerda, ACR; Cognitive function is associated with performance in time up and go test and with leptin blood levels in community-dwelling older women Scientific reports 2024-04-29 [PMID: 38684691] (Human)		Human
Augusto da Costa Teixeira, L;Rocha-Vieira, E;Aparecida Soares, L;Mota de Oliveira, F;Aparecida Oliveira Leopoldino, A;Netto Parentoni, A;Amaral Mendonça, V;Cristina Rodrigues Lacerda, A; The strong inverse association between plasma concentrations of soluble tumor necrosis factor receptors type 1 with adiponectin/leptin ratio in older women Cytokine 2024-01-27 [PMID: 38281360] (Human)		Human
Wu, WC;Shiu, C;Tong, TK;Leung, SO;Hui, CW; Suppression of NK Cell Activation by JAK3 Inhibition: Implication in the Treatment of Autoimmune Diseases Journal of immunology research 2023-12-08 [PMID: 38106519] (Human)		Human
Jalilian, E;Abolhasani-Zadeh, F;Afgar, A;Samoudi, A;Zeinalynezhad, H;Langroudi, L; Neutralizing tumor-related inflammation and reprogramming of cancer-associated fibroblasts by Curcumin in breast cancer therapy Scientific reports 2023-11-26 [PMID: 38008819] (Human)		Human
Han, X;Liu, L;Huang, S;Xiao, W;Gao, Y;Zhou, W;Zhang, C;Zheng, H;Yang, L;Xie, X;Liang, Q;Tu, Z;Yu, H;Fu, J;Wang, L;Zhang, X;Qian, L;Zhou, Y; RNA m6A methylation modulates airway inflammation in allergic asthma via PTX3-dependent macrophage homeostasis Nature communications 2023-11-13 [PMID: 37957139] (Human)		Human
Campesi, I;Capobianco, G;Cano, A;Lodde, V;Cruciani, S;Maioli, M;Sotgiu, G;Idda, ML;Puci, MV;Ruoppolo, M;Costanzo, M;Caterino, M;Cambosu, F;Montella, A;Franconi, F; Stratification of Amniotic Fluid Cells and Amniotic Fluid by Sex Opens Up New Perspectives on Fetal Health Biomedicines 2023-10-18 [PMID: 37893203] (Human)		Human
Fiorillo, A;Gallego, JJ;Casanova-Ferrer, F;Giménez-Garzó, C;Urios, A;Ballester, MP;Durbán, L;Rios, MP;Megías, J;San Miguel, T;Kosenko, E;Escudero-García, D;Benlloch, S;Felipo, V;Montoliu, C; Mild Cognitive Impairment Is Associated with Enhanced Activation of Th17 Lymphocytes in Non-Alcoholic Fatty Liver Disease International journal of molecular sciences 2023-06-20 [PMID: 37373554] (Human)		Human
da Costa Teixeira, LA;Avelar, NCP;Peixoto, MFD;Parentoni, AN;Santos, JMD;Pereira, FSM;Danielewicz, AL;Leopoldino, AAO;Costa, SP;Arrieiro, AN;Soares, LA;da Silva Lage, VK;Prates, ACN;Taiar, R;de Carvalho Bastone, A;Oliveira, VC;Oliveira, MX;Costa, HS;Nobre, JNP;Brant, FP;Duarte, TC;Figueiredo, PHS;Mendonça, VA;Lacerda, ACR; Inflammatory biomarkers at different stages of Sarcopenia in older women Scientific reports 2023-06-26 [PMID: 37365209] (Human)		Human
LAC Teixeira, JM Dos Santos, AN Parentoni, LP Lima, TC Duarte, FP Brant, CDC Neves, FSM Pereira, NCP Avelar, AL Danielewic, AAO Leopoldino, SP Costa, AN Arrieiro, LA Soares, ACN Prates, JNP Nobre, A de Carvalh, VC de Oliveir, MX Oliveira, PH Scheidt Fi, HS Costa, V Amaral Men, R Taiar, AC Rodrigues Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study Journal of Clinical Medicine, 2022-12-02;11(23):. 2022-12-02 [PMID: 36498747] (Human)		Human
F Reverchon, C Guillard, L Mollet, P Auzou, D Gosset, F Madouri, A Valéry, A Menuet, C Ozsancak, M Pallix-Guy, S Morisset-L T Lymphocyte Serotonin 5-HT7 Receptor Is Dysregulated in Natalizumab-Treated Multiple Sclerosis Patients Biomedicines, 2022-09-27;10(10):. 2022-09-27 [PMID: 36289679] (Human)		Human
JP Lapuente, A Blázquez-M, J Marco-Brua, G Gómez, P Desportes, J Sanz, P Fernández, M García-Gil, F Bermejo, JV San Martín, A Algaba, JC De Gregori, D Lapuente, A De Gregori, B Lapuente, MV Andrés, A Anel Cytokine Profile and Anti-Inflammatory Activity of a Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells (PRS CK STORM) Biomolecules, 2022-03-31;12(4):. 2022-03-31 [PMID: 35454123] (Human)		Human
A Tosi, L Nardinocch, ML Carbone, L Capriotti, E Pagani, S Mastroeni, C Fortes, F Scopelliti, C Cattani, F Passarelli, A Rosato, S D'Atri, CM Failla, A Cavani Reduced Interleukin-17-Expressing Cells in Cutaneous Melanoma Biomedicines, 2021-12-16;9(12):. 2021-12-16 [PMID: 34944746] (Human)		Human
G Dunsmore, EP Rosero, S Shahbaz, DM Santer, J Jovel, P Lacy, S Houston, S Elahi Neutrophils promote T-cell activation through the regulated release of CD44-bound Galectin-9 from the cell surface during HIV infection PloS Biology, 2021-08-19;19(8):e3001387. 2021-08-19 [PMID: 34411088] (Human)		Human
LI Lyngfelt, MC Erlandsson, M Nadali, S Hedjazifar, R Pullerits, KM Andersson, P Brembeck, ST Silfverswä, U Smith, MI Bokarewa Impact of the Uncoupling Protein 1 on Cardiovascular Risk in Patients with Rheumatoid Arthritis Cells, 2021-05-07;10(5):. 2021-05-07 [PMID: 34067093] (Human)		Human
RP Madeira, LM Dal'Mas Ro, P de Cássia, C Mady, BM Ianni, AC Torrecilha New Biomarker in Chagas Disease: Extracellular Vesicles Isolated from Peripheral Blood in Chronic Chagas Disease Patients Modulate the Human Immune Response Journal of Immunology Research, 2021-01-11;2021(0):6650670. 2021-01-11 [PMID: 33506056] (Human)		Human
GR Kathamuthu, K Moideen, R Sridhar, D Baskaran, S Babu Altered plasma levels of &betaC and &gammaC chain cytokines and post-treatment modulation in tuberculous lymphadenitis Cytokine, 2020-12-17;138(0):155405. 2020-12-17 [PMID: 33341600] (Human)		Human
M De, A Bhushan, S Chinnaswam Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN-&lambda3 or IFN-&lambda4 show distinct phenotypes J Leukoc Biol, 2020-11-17;0(0):. 2020-11-17 [PMID: 33205487] (Human)		Human
H Kleinertz, M Hepner-Sch, S Ehnert, M Claus, R Halbgebaue, L Boller, M Huber-Lang, P Cinelli, C Kirschning, S Flohé, A Sander, C Waydhas, S Vonderhage, M Jäger, M Dudda, C Watzl, SB Flohé Circulating growth/differentiation factor 15 is associated with human CD56bright natural killer cell dysfunction and nosocomial infection in severe systemic inflammation EBioMedicine, 2019-04-13;0(0):. 2019-04-13 [PMID: 30992245] (Human)		Human
R Gramlich, E Aliahmadi, M Peiser In Vitro Induction of T Helper 17 Cells by Synergistic Activation of Human Monocyte-Derived Langerhans Cell-Like Cells with Bacterial Agonists Int J Mol Sci, 2019-03-19;20(6):. 2019-03-19 [PMID: 30893757] (Human)		Human
A Islam, I Urbarova, JA Bruun, I Martinez-Z Large-scale secretome analyses unveil the superior immunosuppressive phenotype of umbilical cord stromal cells as compared to other adult mesenchymal stromal cells Eur Cell Mater, 2019-02-20;37(0):153-174. 2019-02-20 [PMID: 30785213] (Human)		Human
LK Volpato, VV Horewicz, F Bobinski, DF Martins, AP Piovezan Annexin A1, FPR2/ALX, and inflammatory cytokine expression in peritoneal endometriosis J. Reprod. Immunol., 2018-08-03;129(0):30-35. 2018-08-03 [PMID: 30096622] (Human)		Human
Campia I, Buondonno I, Castella B, Rolando B, Kopecka J, Gazzano E, Ghigo D, Riganti C An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells. PLoS ONE, 2015-05-08;10(5):e0126159. 2015-05-08 [PMID: 25955018] (Human)		Human
Guirado E, Mbawuike U, Keiser T, Arcos J, Azad A, Wang S, Schlesinger L Characterization of host and microbial determinants in individuals with latent tuberculosis infection using a human granuloma model. MBio, 2015-02-17;6(1):e02537-14. 2015-02-17 [PMID: 25691598] (Human)		Human
Liukko A, Kinnunen T, Rytkonen-Nissinen M, Kailaanmaki A, Randell J, Maillere B, Virtanen T Human CD4+ T cell responses to the dog major allergen Can f 1 and its human homologue tear lipocalin resemble each other. PLoS ONE, 2014-05-29;9(5):e98461. 2014-05-29 [PMID: 24875388] (Human)		Human
Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, Debrah AY, Batsa L, Kwarteng A, Epp C, Taylor M, Adjei O, Layland LE, Hoerauf A Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti. PLoS Negl Trop Dis, 2012-04-03;6(4):e1611. 2012-04-03 [PMID: 22509424] (Human)		Human
Napimoga MH, Nunes LH, Maciel AA, Demasi AP, Benatti BB, Santos VR, Bastos MF, de Miranda TS, Duarte PM Possible involvement of IL-21 and IL-10 on salivary IgA levels in chronic periodontitis subjects. Scand. J. Immunol., 2011-12-01;74(6):596-602. 2011-12-01 [PMID: 21815905] (Human)		Human
Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, Garcovich S, Traidl-Hoffmann C, Albanesi C, Cavani A IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes. J. Immunol., 2010-03-31;184(9):4880-8. 2010-03-31 [PMID: 20357258] (Human)		Human
Xu D, Lin L, Lin X Immunoregulation of autocrine prolactin: suppressing the expression of costimulatory molecules and cytokines in T lymphocytes by prolactin receptor knockdown. Cell. Immunol., 2010-03-02;263(1):71-8. 2010-03-02 [PMID: 20307875] (Human)		Human
Christophi GP, Panos M, Hudson CA, Tsikkou C, Mihai C, Mejico LJ, Jubelt B, Massa PT Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1. Clin. Immunol., 2009-06-25;133(1):27-44. 2009-06-25 [PMID: 19559654] (Human)		Human
Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur. J. Immunol., 2009-05-01;39(5):1221-30. 2009-05-01 [PMID: 19350551] (Human)		Human
Maneechotesuwan K, Wamanuttajinda V, Kasetsinsombat K, Huabprasert S, Yaikwawong M, Barnes PJ, Wongkajornsilp A Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma. J. Allergy Clin. Immunol., 2008-12-05;123(1):239-48. 2008-12-05 [PMID: 19058839] (Human)		Human
Correale J, Farez M, Razzitte G Helminth infections associated with multiple sclerosis induce regulatory B cells. Ann. Neurol., 2008-08-01;64(2):187-99. 2008-08-01 [PMID: 18655096] (Human)		Human
Lamhamedi-Cherradi SE, Martin RE, Ito T, Kheradmand F, Corry DB, Liu YJ, Moyle M Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12. J. Immunol., 2008-05-01;180(9):6000-9. 2008-05-01 [PMID: 18424720] (Human)		Human
Weindl G, Naglik JR, Kaesler S, Biedermann T, Hube B, Korting HC, Schaller M Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J. Clin. Invest., 2007-12-01;117(12):3664-3672. 2007-12-01 [PMID: 17992260] (Human)		Human
Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, Preisser L, Anegon I, Catala L, Ifrah N, Descamps P, Gamelin E, Gascan H, Hebbar M, Jeannin P Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood, 2007-09-11;110(13):4319-30. 2007-09-11 [PMID: 17848619] (Human)		Human
Nassenstein C, Kammertoens T, Veres TZ, Uckert W, Spies E, Fuchs B, Krug N, Braun A Neuroimmune crosstalk in asthma: dual role of the neurotrophin receptor p75NTR. J. Allergy Clin. Immunol., 2007-08-22;120(5):1089-96. 2007-08-22 [PMID: 17716721] (Mouse)		Mouse
Monick MM, Powers LS, Hassan I, Groskreutz D, Yarovinsky TO, Barrett CW, Castilow EM, Tifrea D, Varga SM, Hunninghake GW Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17. J. Immunol., 2007-08-01;179(3):1648-58. 2007-08-01 [PMID: 17641031] (Human)		Human
Plante S, Semlali A, Joubert P, Bissonnette E, Laviolette M, Hamid Q, Chakir J Mast cells regulate procollagen I (alpha 1) production by bronchial fibroblasts derived from subjects with asthma through IL-4/IL-4 delta 2 ratio. J. Allergy Clin. Immunol., 2006-02-21;117(6):1321-7. 2006-02-21 [PMID: 16750993] (Human)		Human
Cox AL, Coles AJ, Nortje J, Bradley PG, Chatfield DA, Thompson SJ, Menon DK An investigation of auto-reactivity after head injury. J. Neuroimmunol., 2006-03-06;174(1):180-6. 2006-03-06 [PMID: 16519951] (Human)		Human
Lignell U, Meklin T, Putus T, Vepsalainen A, Roponen M, Torvinen E, Reeslev M, Pennanen S, Hirvonen MR, Kalliokoski P, Nevalainen A Microbial exposure, symptoms and inflammatory mediators in nasal lavage fluid of kitchen and clerical personnel in schools. Int J Occup Med Environ Health, 2005-01-01;18(2):139-50. 2005-01-01 [PMID: 16201205] (Human)		Human
Hajnicka V, Vancova I, Kocakova P, Slovak M, Gasperik J, Slavikova M, Hails RS, Labuda M, Nuttall PA Manipulation of host cytokine network by ticks: a potential gateway for pathogen transmission. Parasitology, 2005-03-01;130(0):333-42. 2005-03-01 [PMID: 15796016] (Human)		Human
Weigt H, Muhlradt PF, Larbig M, Krug N, Braun A The Toll-like receptor-2/6 agonist macrophage-activating lipopeptide-2 cooperates with IFN-gamma to reverse the Th2 skew in an in vitro allergy model. J. Immunol., 2004-05-15;172(10):6080-6. 2004-05-15 [PMID: 15128792] (Human)		Human
Misra A, Dube A, Naik S Immune responses in normal Indian langur monkeys (Presbytis entellus)--a primate model for visceral leishmaniasis. J. Med. Primatol., 2004-04-01;33(2):65-9. 2004-04-01 [PMID: 15061718] (Primate - Presbytis entellus (Indian langur))		Primate - Presbytis entellus (Indian langur)
Purokivi M, Hirvonen MR, Roponen M, Randell J, Vahteristo M, Tukiainen H Comparison of inflammatory elements in nasal lavage and induced sputum following occupational exposure to moldy-building microbes. Inhal Toxicol, 2002-06-01;14(6):653-62. 2002-06-01 [PMID: 12119074] (Human)		Human
Roponen M, Kiviranta J, Seuri M, Tukiainen H, Myllykangas-Luosujarvi R, Hirvonen MR Inflammatory mediators in nasal lavage, induced sputum and serum of employees with rheumatic and respiratory disorders. Eur. Respir. J., 2001-09-01;18(3):542-8. 2001-09-01 [PMID: 11589353] (Human)		Human
Purokivi M, Randell J, Hirvonen MR, Tukiainen H Reproducibility of measurements of exhaled NO, and cell count and cytokine concentrations in induced sputum. Eur. Respir. J., 2000-08-01;16(2):242-6. 2000-08-01 [PMID: 10968498] (Human)		Human
Show All 48 Publications. Collapse Publications.

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• IL-4 Antibodies
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