Human IL-33 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-33 (Interleukin-33) is released from physically damaged or necrotic cells. It triggers Th2-biased immune cell activation at sites of inflammation as well as regulatory T cell and M2 macrophage expansion. It additionally induces angiogenesis, promotes tumor cell migration and invasion, limits cardiac myocyte hypertrophy, and limits the development of atherosclerotic plaques. IL-33 signals through a receptor complex composed of ST2 and IL-1 RAcP. IL-1 RAcP also associates with IL-1 RI, IL-1 RII, IL-1 R6, and SCF R/c-kit. Soluble isoforms of ST2 and IL-1 RAcP function as decoy receptors that regulate IL-33 bioactivity.

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

Showing Publications 1 - 10 of 36. Show All 36 Publications. Collapse Publications.

Publications using DY3625B	Applications	Species
Jiao, M;Wang, C;Tang, X;Dai, C;Zhang, N;Fan, A;Qian, Z;Liu, S;Zhang, F;Li, B;Xu, Y;Tan, Z;Gong, F;Lu, Y;Zheng, F; Active secretion of IL-33 from astrocytes is dependent on TMED10 and promotes central nervous system homeostasis Brain, behavior, and immunity 2024-04-24 [PMID: 38663774] (Mouse, Transgenic Mouse)		Mouse, Transgenic Mouse
Raphael, HE;Hassan, GF;Osorio, OA;Cohen, LS;Payne, MD;Katz-Kiriakos, E;Tata, I;Hicks, J;Byers, DE;Zhang, B;Alexander-Brett, J; Activator protein transcription factors coordinate human IL-33 expression from noncanonical promoters in chronic airway disease JCI insight 2024-03-08 [PMID: 38456508] (Human)		Human
Coufal, S;Kverka, M;Kreisinger, J;Thon, T;Rob, F;Kolar, M;Reiss, Z;Schierova, D;Kostovcikova, K;Roubalova, R;Bajer, L;Jackova, Z;Mihula, M;Drastich, P;Tresnak Hercogova, J;Novakova, M;Vasatko, M;Lukas, M;Tlaskalova-Hogenova, H;Jiraskova Zakostelska, Z; Serum TGF-?1 and CD14 Predicts Response to Anti-TNF-? Therapy in IBD Journal of immunology research 2023-06-20 [PMID: 37383609] (Human)		Human
England, E;Rees, DG;Scott, IC;Carmen, S;Chan, DTY;Chaillan Huntington, CE;Houslay, KF;Erngren, T;Penney, M;Majithiya, JB;Rapley, L;Sims, DA;Hollins, C;Hinchy, EC;Strain, MD;Kemp, BP;Corkill, DJ;May, RD;Vousden, KA;Butler, RJ;Mustelin, T;Vaughan, TJ;Lowe, DC;Colley, C;Cohen, ES; Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction Scientific reports 2023-06-17 [PMID: 37330528] (Human)		Human
Jeon, YJ;Gil, CH;Won, J;Jo, A;Kim, HJ; Symbiotic microbiome Staphylococcus epidermidis restricts IL-33 production in allergic nasal epithelium via limiting the cellular necroptosis BMC microbiology 2023-05-26 [PMID: 37237381] (Mouse)		Mouse
J Nesic, B Ljujic, V Rosic, A Djukic, M Rosic, I Petrovic, N Zornic, IP Jovanovic, S Petrovic, S Djukic Adiponectin and Interleukin-33: Possible Early Markers of Metabolic Syndrome Journal of Clinical Medicine, 2022-12-24;12(1):. 2022-12-24 [PMID: 36614933] (Human)		Human
MH Urban, S Stojkovic, S Demyanets, C Hengstenbe, A Valipour, J Wojta, OC Burghuber Soluble ST2 and All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease-A 10-Year Cohort Study Journal of Clinical Medicine, 2021-12-23;11(1):. 2021-12-23 [PMID: 35011794] (Human)		Human
W Fonseca, N Asai, K Yagi, CA Malinczak, G Savickas, CC Johnson, S Murray, EM Zoratti, NW Lukacs, J Li, CF Schuler Iv COVID-19 Modulates Inflammatory and Renal Markers That May Predict Hospital Outcomes among African American Males Viruses, 2021-12-02;13(12):. 2021-12-02 [PMID: 34960684] (Human)		Human
ICS Dias, SM de Campos-, ELM Vieira, APL Mota, PS Azevedo, VTDS Anício, FC Guimarães, LM Mantovani, BF Cruz, AL Teixeira, JV Salgado Adiponectin and Stnfr2 peripheral levels are associated with cardiovascular risk in patients with schizophrenia Journal of psychiatric research, 2021-11-09;0(0):. 2021-11-09 [PMID: 34785039] (Human)		Human
R Rezar, V Paar, C Seelmaier, I Pretsch, P Schwaiger, K Kopp, R Kaufmann, TK Felder, E Prinz, G Gemes, R Pistulli, UC Hoppe, B Wernly, M Lichtenaue Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study Scientific Reports, 2021-11-05;11(1):21756. 2021-11-05 [PMID: 34741120] (Human)		Human
T Saito, T Ichikawa, T Numakura, M Yamada, A Koarai, N Fujino, K Murakami, S Yamanaka, Y Sasaki, Y Kyogoku, K Itakura, H Sano, K Takita, R Tanaka, T Tamada, M Ichinose, H Sugiura PGC-1&alpha regulates airway epithelial barrier dysfunction induced by house dust mite Respiratory Research, 2021-02-19;22(1):63. 2021-02-19 [PMID: 33607992] (Human)		Human
AER Oliveira, MCA Pereira, AT Belew, LRP Ferreira, LMN Pereira, EGA Neves, MDCP Nunes, BA Burleigh, WO Dutra, NM El-Sayed, RT Gazzinelli, SMR Teixeira Gene expression network analyses during infection with virulent and avirulent Trypanosoma cruzi�strains unveil a role for fibroblasts in neutrophil recruitment and activation PLoS Pathog., 2020-08-18;16(8):e1008781. 2020-08-18 [PMID: 32810179] (Human)		Human
T Li, Z Zhang, JG Bartolacci, GK Dwyer, Q Liu, L Mathews, M Velayutham, A Roessing, YC Lee, H Dai, S Shiva, MH Oberbarnsc, JL Dziki, SJ Mullett, SG Wendell, JD Wilkinson, SA Webber, MA Wood-Trage, SC Watkins, AJ Demetris, GS Hussey, SF Badylak, HR Turnquist Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection J. Clin. Invest., 2020-10-01;0(0):. 2020-10-01 [PMID: 32644975] (Human)		Human
S Demyanets, C Kaun, A Kaider, W Speidl, M Prager, S Oravec, P Hohensinne, J Wojta, G Rega-Kaun The pro-inflammatory marker soluble suppression of tumorigenicity-2 (ST2) is reduced especially in diabetic morbidly obese patients undergoing bariatric surgery Cardiovasc Diabetol, 2020-02-26;19(1):26. 2020-02-26 [PMID: 32101157] (Human)		Human
D Izadi, TB Layton, L Williams, F McCann, M Cabrita, AI Espirito S, W Xie, M Fritzsche, H Colin-York, M Feldmann, KS Midwood, J Nanchahal Identification of TNFR2 and IL-33 as therapeutic targets in localized fibrosis Sci Adv, 2019-12-04;5(12):eaay0370. 2019-12-04 [PMID: 31840071] (Human)		Human
CJ Kuo, CY Chen, HR Lo, CL Feng, HY Wu, MZ Huang, TN Liao, YA Chen, CH Lai Helicobacter pylori Induces IL-33 Production and Recruits ST-2 to Lipid Rafts to Exacerbate Inflammation Cells, 2019-10-21;8(10):. 2019-10-21 [PMID: 31640262] (Human)		Human
N Schaunaman, A Sanchez, KG Dimasuay, N Pavelka, M Numata, R Alam, RJ Martin, HW Chu Interleukin 1 Receptor-Like 1 (IL1RL1) Promotes Airway Bacterial and Viral Infection and Inflammation Infect. Immun., 2019-06-20;87(7):. 2019-06-20 [PMID: 31061143] (Human)		Human
A Taracanova, I Tsilioni, P Conti, ER Norwitz, SE Leeman, TC Theoharide Substance P and IL-33 administered together stimulate a marked secretion of IL-1? from human mast cells, inhibited by methoxyluteolin Proc. Natl. Acad. Sci. U.S.A., 2018-09-19;0(0):. 2018-09-19 [PMID: 30232261] (Human)		Human
RF Hamilton, Z Wu, S Mitra, A Holian The Effects of Varying Degree of MWCNT Carboxylation on Bioactivity in Various In Vivo and In Vitro Exposure Models Int J Mol Sci, 2018-01-25;19(2):. 2018-01-25 [PMID: 29370073] (Human)		Human
C Li, K Chen, H Kang, Y Yan, K Liu, C Guo, J Qi, K Yang, F Wang, L Guo, C He, L Deng Double-stranded RNA released from damaged articular chondrocytes promotes cartilage degeneration via Toll-like receptor 3-interleukin-33 pathway Cell Death Dis, 2017-11-02;8(11):e3165. 2017-11-02 [PMID: 29095435] (Human)		Human
KA Krychtiuk, S Stojkovic, M Lenz, M Brekalo, K Huber, J Wojta, G Heinz, S Demyanets, WS Speidl Predictive value of low interleukin-33 in critically ill patients Cytokine, 2017-09-30;0(0):. 2017-09-30 [PMID: 28974430] (Human)		Human
GA Queiroz, RS Costa, NM Alcantara-, G Nunes de O, ML Barreto, VL Carneiro, CA Figueiredo IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population Int. J. Immunogenet, 2017-04-01;44(2):51-61. 2017-04-01 [PMID: 28266165] (Human)		Human
I Hentschke, A Graser, VO Melichar, A Kiefer, T Zimmermann, B Kro beta , P Haag, P Xepapadaki, NG Papadopoul, C Bogdan, S Finotto IL-33/ST2 immune responses to respiratory bacteria in pediatric asthma Sci Rep, 2017-03-06;7(0):43426. 2017-03-06 [PMID: 28262704] (Human)		Human
Gisa Tiegs A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis J. Immunol., 2016-11-21;0(0):. 2016-11-21 [PMID: 27872212] (Human)		Human
Calven J, Akbarshahi H, Menzel M, Ayata C, Idzko M, Bjermer L, Uller L Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33. J Transl Med, 2015-08-29;13(0):281. 2015-08-29 [PMID: 26318341] (Human)		Human
Sundnes O, Pietka W, Loos T, Sponheim J, Rankin A, Pflanz S, Bertelsen V, Sitek J, Hol J, Haraldsen G, Khnykin D Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences. J Invest Dermatol, 2015-03-04;135(7):1771-80. 2015-03-04 [PMID: 25739051] (Human)		Human
Hasan , Amal, Al-Ghimlas , Fahad, Warsame , Samia, Al-Hubail , Asma, Ahmad , Rasheed, Bennakhi , Abdullah, Al-Arouj , Monira, Behbehani , Kazem, Dehbi , Mohammed, Dermime , Said IL-33 is negatively associated with the BMI and confers a protective lipid/metabolic profile in non-diabetic but not diabetic subjects. BMC Immunol, 2014-05-10;15(0):19. 2014-05-10 [PMID: 24886535] (Human)		Human
Lu , Da-Peng, Zhou , Xiang-Yu, Yao , Lu-Tian, Liu , Cai-Gang, Ma , Wei, Jin , Feng, Wu , Yun-Fei Serum soluble ST2 is associated with ER-positive breast cancer. BMC Cancer, 2014-03-18;14(0):198. 2014-03-18 [PMID: 24636276] (Human)		Human
Guerrero C, Arrieta A, Ramirez N, Rodriguez L, Vega R, Bosch I, Rodriguez J, Narvaez C, Salgado D High plasma levels of soluble ST2 but not its ligand IL-33 is associated with severe forms of pediatric dengue. Cytokine, 2013-01-26;61(3):766-71. 2013-01-26 [PMID: 23357301] (Human)		Human
Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J. Exp. Med., 2012-07-16;209(8):1505-17. 2012-07-16 [PMID: 22802353] (Human)		Human
Kamekura R, Kojima T, Takano K, Go M, Sawada N, Himi T The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis. Clin. Exp. Allergy, 2012-02-01;42(2):218-28. 2012-02-01 [PMID: 22233535] (Human)		Human
Granne I, Southcombe JH, Snider JV ST2 and IL-33 in pregnancy and pre-eclampsia. PLoS ONE, 2011-09-16;6(9):e24463. 2011-09-16 [PMID: 21949719] (Human)		Human
Rechardt M, Shiri R, Matikainen S, Viikari-Juntura E, Karppinen J, Alenius H Soluble IL-1RII and IL-18 are associated with incipient upper extremity soft tissue disorders. Cytokine, 2011-03-02;54(2):149-53. 2011-03-02 [PMID: 21371906] (Human)		Human
Miyagaki T, Sugaya M High Levels of Soluble ST2 and Low Levels of IL-33 in Sera of Patients with HIV Infection. J. Invest. Dermatol., 2010-12-09;131(0):794. 2010-12-09 [PMID: 21150924] (Human)		Human
Mildner M, Storka A, Lichtenauer M Primary sources and immunological prerequisites for sST2 secretion in humans. Cardiovasc. Res., 2010-04-02;87(4):769-77. 2010-04-02 [PMID: 20363761] (Human)		Human
Nishida A, Andoh A, Imaeda H, Inatomi O, Shiomi H, Fujiyama Y Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts. Gut, 2009-12-08;59(4):531-41. 2009-12-08 [PMID: 19996325] (Human)		Human
Show All 36 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Patricia Carulla Martí			06/28/2023	View Summary Sample Tested Cultured Human Keratinocytes,Supernatant from cultured human epidermal keratinocytes (HEKa) Lot P163207

Array DY3625B

• IL-33 Antibodies
• IL-33 Antibody Pair
• IL-33 ELISA Kits
• IL-33 Lysate
• IL-33 Proteins
• IL-33 Proteins and Enzymes
• IL-33 ELISAs