Human IL-2 Quantikine HS ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 2 (IL-2), also known as T cell growth factor (TCGF), is a 15-18 kDa variably glycosylated alpha -helical polypeptide that is a member of the Common gamma Chain ( gamma c) cytokine family (1-4). It exists as a monomer and has a notably short half-life (< 30 minutes) (1). Human IL-2 is synthesized as a 153 amino acid (aa) precursor that contains a 20 aa signal sequence plus a 133 aa mature region (5, 6). The mature region is alpha -helical in nature, and contains one utilized O-linked glycosylation site at Thr3 plus three cysteines, two of which form an intrachain disulfide bond that is essential for activity (7). Mature human IL-2 shares 73%, 66%, 78% and 97% aa identity with canine, rat, feline and rhesus monkey IL-2, respectively. Although human IL-2 shares only approximately 60% aa identity with the highly polymorphic mouse IL-2, human IL-2 is known to be active on mouse IL-2 responsive cells. Cells reported to secrete IL-2 include gamma δ T cells (8), activated conventional CD4+ and CD8+ T cells (1, 9), neurons (10, 11), microglia (12), and hematopoietic stem cells (13). 

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 8 of 8.

Publications using HS200	Applications	Species
Koutaki, D;Paltoglou, G;Manou, M;Vourdoumpa, A;Ramouzi, E;Tzounakou, AM;Michos, A;Bacopoulou, F;Mantzou, E;Zoumakis, E;Papadopoulou, M;Kassari, P;Charmandari, E; The Role of Secreted Frizzled-Related Protein 5 (Sfrp5) in Overweight and Obesity in Childhood and Adolescence Nutrients 2024-09-17 [PMID: 39339733] (Human)		Human
Okura, Y;Ikawa-Teranishi, Y;Mizoroki, A;Takahashi, N;Tsushima, T;Irie, M;Harfuddin, Z;Miura-Okuda, M;Ito, S;Nakamura, G;Takesue, H;Ozono, Y;Nishihara, M;Yamada, K;Gan, SW;Hayasaka, A;Ishii, S;Wakabayashi, T;Muraoka, M;Nagaya, N;Hino, H;Nemoto, T;Kuramochi, T;Torizawa, T;Shimada, H;Kitazawa, T;Okazaki, M;Nezu, J;Sollid, LM;Igawa, T; Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease Nature communications 2023-12-22 [PMID: 38135691] (Human)		Human
Z Albar, M Albakri, J Hajjari, M Karnib, SE Janus, SG Al-Kindi Inflammatory Markers and Risk of Heart Failure With Reduced to Preserved Ejection Fraction The American journal of cardiology, 2022-01-03;0(0):. 2022-01-03 [PMID: 34986991] (Human)		Human
MM Leite, MT Dutra, MVG da Costa, SS Funghetto, AO Silva, LR de Lima, ICR da Silva, MR Mota, MM Stival Comparative evaluation of inflammatory parameters and substitute insulin resistance indices in elderly women with and without type 2 diabetes mellitus Experimental gerontology, 2021-05-03;150(0):111389. 2021-05-03 [PMID: 33957262] (Human)		Human
C Lange, A Machado We, R Schmidt, C Schroeder, T Strowitzki, A Germeyer Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line PLoS ONE, 2021-03-09;16(3):e0248103. 2021-03-09 [PMID: 33690729] (Human)		Human
F Hernández-, MJ Ruiz-de-Le, I Rosado-Sán, E Vázquez, M Leal, S Moreno, F Vidal, J Blanco, YM Pacheco, A Vallejo New signatures of poor CD4 cell recovery after suppressive antiretroviral therapy in HIV-1-infected individuals: involvement of miR-192, IL-6, sCD14 and miR-144 Sci Rep, 2020-02-19;10(1):2937. 2020-02-19 [PMID: 32076107] (Human)		Human
I Conejero, I Jaussent, A Cazals, E Thouvenot, T Mura, E Le Bars, S Guillaume, S Squalli, P Courtet, E Olié Association between baseline pro-inflammatory cytokines and brain activation during social exclusion in patients with vulnerability to suicide and depressive disorder Psychoneuroendocrinology, 2018-10-04;99(0):236-242. 2018-10-04 [PMID: 30326381] (Human)		Human
Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. Clin. Cancer Res., 2006-01-15;12(2):376-82. 2006-01-15 [PMID: 16428475] (Human)		Human

Array HS200

• IL-2 Antibodies
• IL-2 ELISA Kits
• IL-2 Kit
• IL-2 Lysate
• IL-2 Proteins
• IL-2 Proteins and Enzymes
• IL-2 ELISAs