Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Human IL-1 RI DuoSet ELISA, 15 Plate
CD121 antigen-like family member A
CD121a antigen
CD121a
IL-1 RI
IL1R
IL1R1
IL1RI
IL-1RI
IL1RT1
IL-1RT1
IL-1RT-1
Interleukin 1 Receptor 1
interleukin 1 receptor, type I
interleukin receptor 1
interleukin-1 receptor type 1
p80
Background
IL-1 RI, also known as the type 1 IL-1 receptor and CD121a, is a transmembrane protein in the Toll/IL-1 R (TIR) superfamily. IL-1 RI binds the pleiotropic cytokines IL-1 alpha and IL-1 beta, plus the IL-1 receptor antagonist (IL-1 Ra). Signal transduction requires complex formation with IL-1 R AcP/IL-1 R3. This complex recruits the adaptor protein MyD88, to initiate signaling in the NF kappa B pathway. IL-1 RI is expressed predominantly by T cells, fibroblasts, and endothelial cells and mediates acute phase inflammatory responses including fever.