Species: Mu
Applications: WB, IHC, B/N
Host: Goat Polyclonal
Species: Hu
Applications: WB, Flow, B/N, CyTOF-ready
Host: Goat Polyclonal
Species: Hu
Applications: WB, ELISA(Cap)
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Host: Rabbit
Species: Rt
Applications: ELISA
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: Bioactivity
Species: Mu
Applications: Bioactivity
Description
The Interleukin 1 receptor type I (IL-1R1) belongs to the IL-1 receptor family (1). IL-1R1 binds to IL-1 alpha, IL-1 beta, and interleukin-1 receptor antagonist protein (IL-1RA). IL-1RA regulates IL-1 ligand biological activity by a competitive interaction for IL-1R1. Upon IL-1 stimulation, adaptor molecule MyD88 is first recruited to the IL-1R1-IL1R accessory protein complex, followed by the recruitment of two serine-threonine kinases, IRAK4 and IRAK, and the adaptor protein TRAF6, resulting in activation of the NF-kB pathway (2-3). Stimulation of IL-1R1, leads to activation of the transcription factors NF-B, ATF, and AP-1.
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Mouse
Human
|
| Product By Gene ID |
3554 |
| Alternate Names |
- CD121 antigen-like family member A
- CD121a antigen
- IL1R
- Il1r1
- IL1R1
- IL1RT1
- IL-1RT1
- IL-1RT-1
- Interleukin 1 Receptor 1
- interleukin 1 receptor, type I
- interleukin receptor 1
- interleukin-1 receptor type 1
- p80
|
![Immunohistochemistry IL-1 RI Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IL1_RI_AF771_Immunohistochemistry_22597.jpg)
![Flow Cytometry IL-1 RI Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IL-1_RI_AF269_Flow_Cytometry_9910.jpg)
![Sandwich ELISA IL-1 RI Antibody Pair [HRP]](http://images.novusbio.com/fullsize/IL-1-RI-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79665-img0001.jpg)
![Sandwich ELISA IL-1 RI Antibody Pair [HRP]](http://images.novusbio.com/fullsize/IL-1-RI-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79604-img0001.jpg)
![Sandwich ELISA IL-1 RI Antibody Pair [HRP]](http://images.novusbio.com/fullsize/IL-1-RI-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79625-img0001.jpg)
![N/A IL-1 RI [Biotin]](http://images.novusbio.com/fullsize2/DATA_IL1_RI_DY269_ELISA_1875.jpg)
![N/A IL-1 RI [Biotin]](http://images.novusbio.com/fullsize2/DATA_IL1_RI_DY77105_ELISA_2513.jpg)
![Neutralization IL-1 RI Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IL-1_RI_AF771_Block_Neutralize_8962.jpg)
![Neutralization IL-1 RI Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IL-1_RI_AF269_Block_Neutralize_8838.jpg)
![Immunocytochemistry/ Immunofluorescence IL-1 RI Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af269_human-il-1-ri-affinity-purified-polyclonal-ab-8220249505956.jpg)
![Immunocytochemistry/ Immunofluorescence IL-1 RI Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af269_human-il-1-ri-affinity-purified-polyclonal-ab-44202415425024.jpg)
