Human IFN-beta Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

We have publications tested in 3 confirmed species: Human, Mouse, Cynomolgus Monkey.

We have publications tested in 1 application: ELISA Capture.

Showing Publications 1 - 10 of 22. Show All 22 Publications. Collapse Publications.

Publications using DIFNB0	Applications	Species
Reuschl, AK;Thorne, LG;Whelan, MVX;Ragazzini, R;Furnon, W;Cowton, VM;De Lorenzo, G;Mesner, D;Turner, JLE;Dowgier, G;Bogoda, N;Bonfanti, P;Palmarini, M;Patel, AH;Jolly, C;Towers, GJ; Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants Nature microbiology 2024-01-16 [PMID: 38228858] (Human)		Human
A Hooftman, CG Peace, DG Ryan, EA Day, M Yang, AF McGettrick, M Yin, EN Montano, L Huo, JE Toller-Kaw, V Zecchini, TAJ Ryan, A Bolado-Car, AM Casey, HA Prag, ASH Costa, G De Los San, M Ishimori, DJ Wallace, S Venuturupa, E Nikitopoul, N Frizzell, C Johansson, A Von Kriegs, MP Murphy, C Jefferies, C Frezza, LAJ O'Neill Macrophage fumarate hydratase restrains mtRNA-mediated interferon production Nature, 2023-03-08;615(7952):490-498. 2023-03-08 [PMID: 36890227] (Human)		Human
JY Li, Y Zhao, S Gong, MM Wang, X Liu, QM He, YQ Li, SY Huang, H Qiao, XR Tan, ML Ye, XH Zhu, SW He, Q Li, YL Liang, KL Chen, SW Huang, QJ Li, J Ma, N Liu TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models Nature Communications, 2023-02-16;14(1):865. 2023-02-16 [PMID: 36797289] (Human)		Human
J Nassour, LG Aguiar, A Correia, TT Schmidt, L Mainz, S Przetocka, C Haggblom, N Tadepalle, A Williams, MN Shokhirev, SC Akincilar, V Tergaonkar, GS Shadel, J Karlseder Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis Nature, 2023-02-08;614(7949):767-773. 2023-02-08 [PMID: 36755096] (Human)		Human
TK Kim, S Jeon, S Park, SK Sonn, S Seo, J Suh, J Jin, HY Kweon, S Kim, SH Moon, O Kweon, BH Koo, N Kim, HO Lee, YM Kim, YJ Kim, SH Park, GT Oh 2'-5' oligoadenylate synthetase?like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability Nature Communications, 2022-11-04;13(1):6647. 2022-11-04 [PMID: 36333342] (Human, Mouse)		Human, Mouse
CH Song, YH Kim, M Naskar, BW Hayes, MA Abraham, JH Noh, G Suk, MJ Kim, KS Cho, M Shin, EJ Lee, SN Abraham, HW Choi Lactobacillus crispatus Limits Bladder Uropathogenic E. coli Infection by Triggering a Host Type I Interferon Response Proceedings of the National Academy of Sciences of the United States of America, 2022-08-08;119(33):e2117904119. 2022-08-08 [PMID: 35939684] (Human)		Human
C Song, D Liu, S Liu, D Li, I Horecny, X Zhang, P Li, L Chen, M Miller, R Chowdhury, M Issa, R Shen, Y Yan, F Zhang, L Zhang, L Zhang, C Bai, J Feng, L Zhuang, R Zhang, J Li, H Wilkinson, J Liu, W Tao SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis Scientific Reports, 2022-05-20;12(1):8579. 2022-05-20 [PMID: 35595822] (Cynomolgus Monkey, Human)		Cynomolgus Monkey, Human
KC Huang, D Chanda, S McGrath, V Dixit, C Zhang, J Wu, K Tendyke, H Yao, R Hukkanen, N Taylor, D Verbel, DS Kim, A Endo, TA Noland, Y Chen, M Matijevic, J Wang, J Hutz, N Sarwar, FG Fang, X Bao Pharmacological Activation of STING in Bladder Induces Potent Anti-tumor Immunity in Non-Muscle Invasive Murine Bladder Cancer Molecular Cancer Therapeutics, 2022-06-01;0(0):. 2022-06-01 [PMID: 35313332] (Mouse)		Mouse
Z Gao, X Zhang, L Zhang, S Wu, J Ma, F Wang, Y Zhou, X Dai, E Bullitt, Y Du, JT Guo, J Chang A yellow fever virus NS4B inhibitor not only suppresses viral replication, but also enhances the virus activation of RIG-I-like receptor-mediated innate immune response PloS Pathogens, 2022-01-21;18(1):e1010271. 2022-01-21 [PMID: 35061864] (Human)		Human
R Ishida, J Cole, J Lopez-Oroz, N Fayad, A Felix-Lope, M Elaish, SY Luo, O Julien, A Kumar, TC Hobman Mayaro Virus Non-Structural Protein 2 Circumvents the Induction of Interferon in Part by Depleting Host Transcription Initiation Factor IIE Subunit 2 Cells, 2021-12-12;10(12):. 2021-12-12 [PMID: 34944018] (Human)		Human
AH Pham, J Mitchell, S Botto, KM Pryke, VR DeFilippis, MH Hancock Human cytomegalovirus blocks canonical TGFbeta signaling during lytic infection to limit induction of type I interferons PloS Pathogens, 2021-08-19;17(8):e1009380. 2021-08-19 [PMID: 34411201] (Human)		Human
U Rand, SY Kupke, H Shkarlet, MD Hein, T Hirsch, P Marichal-G, L Cicin-Sain, U Reichl, D Bruder Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity Cells, 2021-07-11;10(7):. 2021-07-11 [PMID: 34359926] (Human)		Human
Y Li, C Bax, J Patel, T Vazquez, A Ravishanka, MM Bashir, M Grinnell, D Diaz, VP Werth Plasma-derived DNA containing-extracellular vesicles induce STING-mediated proinflammatory responses in dermatomyositis Theranostics, 2021-05-21;11(15):7144-7158. 2021-05-21 [PMID: 34158841] (Human)		Human
G Miglietta, M Russo, RC Duardo, G Capranico G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells Nucleic Acids Research, 2021-07-09;0(0):. 2021-07-09 [PMID: 34139015] (Human)		Human
S Al-Beltagi, CA Preda, LV Goulding, J James, J Pu, P Skinner, Z Jiang, BL Wang, J Yang, AC Banyard, KH Mellits, P Gershkovic, CJ Hayes, J Nguyen-Van, IH Brown, J Liu, KC Chang Thapsigargin Is a Broad-Spectrum Inhibitor of Major Human Respiratory Viruses: Coronavirus, Respiratory Syncytial Virus and Influenza A Virus Viruses, 2021-02-03;13(2):. 2021-02-03 [PMID: 33546185] (Human)		Human
K Yu, H Tian, H Deng PPM1G restricts innate immune signaling mediated by STING and MAVS and is hijacked by KSHV for immune evasion Sci Adv, 2020-11-20;6(47):. 2020-11-20 [PMID: 33219031] (Human)		Human
HJ Hurley, H Dewald, ZS Rothkopf, S Singh, F Jenkins, P Deb, S De, BJ Barnes, P Fitzgerald Frontline Science: AMPK regulates metabolic reprogramming necessary for interferon production in human plasmacytoid dendritic cells J. Leukoc. Biol., 2020-07-08;0(0):. 2020-07-08 [PMID: 32640499] (Human)		Human
JH Seo, CS Hwang, JY Yoo MTFMT deficiency correlates with reduced mitochondrial integrity and enhanced host susceptibility to intracellular infection Sci Rep, 2020-07-07;10(1):11183. 2020-07-07 [PMID: 32636430] (Human)		Human
SF Watson, N Bellora, S Macias ILF3 contributes to the establishment of the antiviral type I interferon program Nucleic Acids Res., 2020-01-10;0(0):. 2020-01-10 [PMID: 31701124] (Human)		Human
Y Wang, S Yuan, X Jia, Y Ge, T Ling, M Nie, X Lan, S Chen, A Xu Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS Nat. Cell Biol., 2019-11-04;21(11):1346-1356. 2019-11-04 [PMID: 31685995] (Mouse)		Mouse
Q Zhao, Y Wei, SJ Pandol, L Li, A Habtezion STING Signaling Promotes Inflammation in Experimental Acute Pancreatitis Gastroenterology, 2018-02-06;0(0):. 2018-02-06 [PMID: 29425920] (Human)		Human
H Mori, M Murakami, T Tsuda, K Kameda, R Utsunomiya, K Masuda, K Shiraishi, X Dai, M Tohyama, H Nakaoka, K Sayama Reduced-HMGB1 suppresses poly(I:C)-induced inflammation in keratinocytes J. Dermatol. Sci., 2018;0(0):. 2018 [PMID: 29395576] (ELISA Capture, Human)	ELISA Capture	Human
Show All 22 Publications. Collapse Publications.

Array DIFNB0

• IFN-beta Antibodies
• IFN-beta ELISA Kits
• IFN-beta Lysate
• IFN-beta Proteins
• IFN-beta Proteins and Enzymes
• IFN-beta ELISAs