Human DPPIV/CD26 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

DPPIV/CD26 is a serine exopeptidase that is expressed as a noncovalent homodimer on the surface of epithelial cells, endothelial cells, and activated lymphocytes. It regulates multiple aspects of immune and endocrine function by cleaving Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of a wide variety of chemokines (CCL4 and 5, CXCL6, 9, 10, 11, and 12), growth factors (GM-CSF, IL-3), and peptide hormones (Glucagon, Glucagon-like Peptides 1 and 2, GIP, GHRH, Procalcitonin, Neuropeptide Y, and Substance P). DPPIV interacts in cis with Adenosine Deaminase on T cells, in trans with Caveolin-1 on antigen presenting cells, and it serves as a cell entry coreceptor for HIV and coronavirus. It provides costimulatory proliferation and activation signals to both CD4+ and CD8+ T cells. A soluble form of DPPIV can be proteolytically shed from adipocytes, leading to insulin resistance in adipocytes and skeletal muscle.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using DY1180	Applications	Species
Höpfinger, A;Karrasch, T;Schäffler, A;Schmid, A; Circulating Concentrations of Cathelicidin Anti-Microbial Peptide (CAMP) Are Increased during Oral Glucose Tolerance Test International journal of molecular sciences 2023-08-17 [PMID: 37629082] (Human)		Human
Höpfinger, A;Karrasch, T;Schäffler, A;Schmid, A; Circulating Levels of Cathelicidin Antimicrobial Peptide (CAMP) Are Affected by Oral Lipid Ingestion Nutrients 2023-07-03 [PMID: 37447348] (Human)		Human
OJ Cordero, C Rafael-Vid, R Varela-Cal, C Calviño-Sa, B Malvar-Fer, S García, JE Viñuela, JM Pego-Reigo Distinctive CD26 Expression on CD4 T-Cell Subsets Biomolecules, 2021-10-02;11(10):. 2021-10-02 [PMID: 34680079] (Human)		Human
E Krepela, Z Vanickova, P Hrabal, M Zubal, B Chmielova, E Balaziova, P Vymola, I Matrasova, P Busek, A Sedo Regulation of Fibroblast Activation Protein by Transforming Growth Factor Beta-1 in Glioblastoma Microenvironment International Journal of Molecular Sciences, 2021-01-21;22(3):. 2021-01-21 [PMID: 33494271] (Human)		Human
AA Raha, S Chakrabort, J Henderson, E Mukaetova-, S Zaman, J Trowsdale, R Raha-Chowd Investigation of CD26, a potential SARS-CoV-2 receptor, as a biomarker of age and pathology Biosci Rep, 2020-12-23;40(12):. 2020-12-23 [PMID: 33205807] (Human)		Human
LL Baggio, EM Varin, JA Koehler, X Cao, Y Lokhnygina, SR Stevens, RR Holman, DJ Drucker Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans Nat Commun, 2020-07-28;11(1):3766. 2020-07-28 [PMID: 32724076] (Human)		Human
NM Varda, M Medved, L Ojsteršek The associations between some biological markers, obesity, and cardiovascular risk in Slovenian children and adolescents BMC Pediatr, 2020-02-21;20(1):81. 2020-02-21 [PMID: 32085704] (Human)		Human
L De Chiara, M Páez de la, J Rodríguez-, MC Alvarez-Pa, MC Pardiñas-A, R Varela-Cal, OJ Cordero CD26-Related Serum Biomarkers: sCD26 Protein, DPP4 Activity, and Anti-CD26 Isotype Levels in a Colorectal Cancer-Screening Context Dis. Markers, 2020-01-21;2020(0):4347936. 2020-01-21 [PMID: 32051696] (Human)		Human
MJ Ploquin, A Casrouge, Y Madec, N Noël, B Jacquelin, N Huot, D Duffy, SP Jochems, L Micci, C Lécuroux, F Boufassa, T Booiman, T Garcia-Tel, M Ghislain, RL Grand, O Lambotte, N Kootstra, L Meyer, C Goujard, M Paiardini, ML Albert, M Müller-Tru Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage J Int AIDS Soc, 2018-07-01;21(7):e25144. 2018-07-01 [PMID: 29987877] (Human)		Human
Matrasova I, Busek P, Balaziova E, Sedo A Heterogeneity of molecular forms of dipeptidyl peptidase-IV and fibroblast activation protein in human glioblastomas. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2017-04-26;161(3):252-260. 2017-04-26 [PMID: 28452380] (Human)		Human
Sromova L, Busek P, Sedova L, Sedo A Intraindividual changes of dipeptidyl peptidase-IV in peripheral blood of patients with rheumatoid arthritis are associated with the disease activity. BMC Musculoskelet Disord, 2015-09-09;16(0):244. 2015-09-09 [PMID: 26353808] (Human)		Human
Rohrborn D, Eckel J, Sell H Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells. FEBS Lett, 2014-09-12;588(21):3870-7. 2014-09-12 [PMID: 25217834] (Human)		Human
Show All 12 Publications. Collapse Publications.

Array DY1180

• DPPIV/CD26 Antibodies
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• DPPIV/CD26 ELISAs
• DPPIV/CD26 Proteins and Enzymes