Name: Human Caspase-1/ICE Quantikine ELISA Kit
Brand: Novus Biologicals
SKU: DCA100
Price: 635 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	ELISA
Conjugate	HRP

Background	The Quantikine Human Caspase-1 Immunoassay is a 3 hour solid phase ELISA designed to measure Caspase-1 in cell culture supernates. It contains recombinant human Caspase-1 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained measuring natural human Caspase-1 showed dose-response curves that were... parallel to the standard curves obtained using the recombinant Caspase-1. These results indicate that this kit can be used to determine relative mass values for natural human Caspase-1. Show More
Specificity	Natural and recombinant human Caspase-1
Source	N/A
Assay Type	Solid Phase Sandwich ELISA
Inter-Assay	See PDF Datasheet for details
Intra-Assay	See PDF Datasheet for details
Spike Recovery	See PDF Datasheet for details
Sample Volume	See PDF Datasheet for details
Gene	CASP1

Publications using DCA100	Applications	Species
Thirugnanam, S;Wang, C;Zheng, C;Grasperge, BF;Datta, PK;Rappaport, J;Qin, X;Rout, N; The Association between IL-1? and IL-18 Levels, Gut Barrier Disruption, and Monocyte Activation during Chronic Simian Immunodeficiency Virus Infection and Long-Term Suppressive Antiretroviral Therapy International journal of molecular sciences 2024-08-09 [PMID: 39201388] (Rhesus Macaque)		Rhesus Macaque
Matsumoto, H;Yoshida, S;Koga, T;Fujita, Y;Sumichika, Y;Saito, K;Temmoku, J;Asano, T;Sato, S;Mizokami, M;Sugiyama, M;Migita, K; Increased serum caspase-1 in adult-onset Still's disease PloS one 2024-07-29 [PMID: 39074125] (Human)		Human
Elovitz, M;Anton, L;Cristancho, A;Ferguson, B;Joseph, A;Ravel, J; Vaginal microbes alter epithelial transcriptome and induce epigenomic modifications providing insight into mechanisms for susceptibility to adverse reproductive outcomes Research square 2024-05-31 [PMID: 38854063] (Human)		Human
Mohammed, OA;Saber, S;Abdel-Reheim, MA;Alamri, MMS;Alfaifi, J;Adam, MIE;Alharthi, MH;Eleragi, AMS;Eltahir, HB;Abdalla, MO;Bahashwan, E;Ibrahim, EK;Rezigalla, AA;Abdel-Ghany, S;Alzokaky, AA;Doghish, AS;El-Husseiny, HM;Alghamdi, M;Youssef, ME; Tracking the therapeutic efficacy of a ketone mono ester and ?-hydroxybutyrate for ulcerative colitis in rats: New perspectives Toxicology and applied pharmacology 2024-04-26 [PMID: 38677600] (Human)		Human
Elovitz, M;Anton, L;Cristancho, A;Ferguson, B;Joseph, A;Ravel, J; Vaginal microbes alter epithelial transcriptomic and epigenomic modifications providing insight into the molecular mechanisms for susceptibility to adverse reproductive outcomes Research square 2023-11-16 [PMID: 38014044] (Human)		Human
Nieto-Veloza, A;Hong, S;Reeder, M;Sula, MJ;D'Souza, DH;Zhong, Q;Dia, VP; Lunasin reduces the susceptibility of IL-10 deficient mice to inflammatory bowel disease and modulates the activation of the NLRP3 inflammasome The Journal of nutritional biochemistry 2023-05-18 [PMID: 37209953] (Human)		Human
SR Schnittman, DW Kitch, TH Swartz, TH Burdo, KV Fitch, S McCallum, JM Flynn, ES Fulda, MR Diggs, JT Stapleton, JL Casado, J Taron, JS Currier, MV Zanni, C Malvestutt, CJ Fichtenbau, JA Aberg, HJ Ribaudo, MT Lu, PS Douglas, SK Grinspoon Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus Open forum infectious diseases, 2023-03-01;10(3):ofad106. 2023-03-01 [PMID: 36998633] (Human)		Human
T Mokhtari, LP Yue, L Hu Exogenous melatonin alleviates neuropathic pain-induced affective disorders by suppressing NF-kappaB/ NLRP3 pathway and apoptosis Scientific Reports, 2023-02-06;13(1):2111. 2023-02-06 [PMID: 36747075] (Rat)		Rat
F La Rosa, CP Zoia, C Bazzini, A Bolognini, M Saresella, E Conti, C Ferrarese, F Piancone, I Marventano, D Galimberti, C Fenoglio, E Scarpini, M Clerici Modulation of MAPK- and PI3/AKT-Dependent Autophagy Signaling by Stavudine (D4T) in PBMC of Alzheimer's Disease Patients Cells, 2022-07-12;11(14):. 2022-07-12 [PMID: 35883623] (Human)		Human
I Alfian, A Chakrabort, HEJ Yong, S Saini, RWK Lau, B Kalionis, E Dimitriadi, N Alfaidy, SD Ricardo, CS Samuel, P Murthi The Placental NLRP3 Inflammasome and Its Downstream Targets, Caspase-1 and Interleukin-6, Are Increased in Human Fetal Growth Restriction: Implications for Aberrant Inflammation-Induced Trophoblast Dysfunction Cells, 2022-04-21;11(9):. 2022-04-21 [PMID: 35563719] (Human)		Human
N Bhattarai, E Korhonen, Y Mysore, K Kaarnirant, A Kauppinen Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells Cells, 2021-06-06;10(6):. 2021-06-06 [PMID: 34204067] (Human)		Human
CY Wu, WL Fan, YM Chiu, HY Yang, WI Lee, JL Huang Lipopolysaccharide stimulation test on cultured PBMCs assists the discrimination of cryopyrin-associated periodic syndrome from systemic juvenile idiopathic arthritis Scientific Reports, 2021-06-07;11(1):11903. 2021-06-07 [PMID: 34099791] (Human)		Human
Y Chen, Q Fujuan, E Chen, B Yu, F Zuo, Y Yuan, X Zhao, C Xiao Expression of AIM2 in Rheumatoid Arthritis and Its Role on Fibroblast-Like Synoviocytes Mediators Inflamm, 2020-10-26;2020(0):1693730. 2020-10-26 [PMID: 33162829] (Human)		Human
M Toribio, TH Burdo, ES Fulda, M Cetlin, SM Chu, MN Feldpausch, GK Robbins, TG Neilan, K Melbourne, SK Grinspoon, MV Zanni Effects of Integrase Inhibitor-Based ART on the NLRP3 Inflammasome Among ART-Naï¿½ve People With HIV Open Forum Infect Dis, 2020-09-29;7(10):ofaa459. 2020-09-29 [PMID: 33134423] (Human)		Human
Y Fujita, N Matsuoka, J Temmoku, M Furuya-Yas, T Asano, S Sato, H Matsumoto, H Watanabe, H Kozuru, H Yatsuhashi, A Kawakami, K Migita JAK inhibitors impair GM-CSF-mediated signaling in innate immune cells BMC Immunol., 2020-06-15;21(1):35. 2020-06-15 [PMID: 32539713] (Human)		Human
V Lavallard, D Cottet-Dum, CH Wassmer, C Rouget, G Parnaud, E Brioudes, F Lebreton, K Bellofatto, E Berishvili, T Berney, D Bosco NLRP3 Inflammasome is Activated in Rat Pancreatic Islets by Transplantation and Hypoxia Sci Rep, 2020-04-24;10(1):7011. 2020-04-24 [PMID: 32332867] (Rat)		Rat
RVH de Carvalh, DS Lima-Junio, MVG da Silva, M Dilucca, TS Rodrigues, CV Horta, ALN Silva, PF da Silva, FG Frantz, LB Lorenzon, MM Souza, F Almeida, LM Cantanhêde, RGM Ferreira, AK Cruz, DS Zamboni Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition Nat Commun, 2019-11-21;10(1):5273. 2019-11-21 [PMID: 31754185] (Human)		Human
MF Wu, CC Shu, JY Wang, BS Yan, HC Lai, BL Chiang, LS Wu, CJ Yu NLRP3 inflammasome is attenuated in patients with Mycobacterium avium complex lung disease and correlated with decreased interleukin-1 Î² response and host susceptibility Sci Rep, 2019-08-29;9(1):12534. 2019-08-29 [PMID: 31467293] (Human)		Human
GCC Weis, CE Assmann, FC Cadoná, BDSR Bonadiman, AO Alves, AK Machado, MMMF Duarte, IBM da Cruz, IH Costabeber Immunomodulatory effect of mancozeb, chlorothalonil, and thiophanate methyl pesticides on macrophage cells Ecotoxicol. Environ. Saf., 2019-07-09;182(0):109420. 2019-07-09 [PMID: 31299472] (Mouse)		Mouse
MY Furuya, T Asano, Y Sumichika, S Sato, H Kobayashi, H Watanabe, E Suzuki, H Kozuru, H Yatsuhashi, T Koga, H Ohira, H Sekine, A Kawakami, K Migita Tofacitinib inhibits granulocyte-macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils Arthritis Res. Ther., 2018-08-29;20(1):196. 2018-08-29 [PMID: 30157949] (Human)		Human
VM Ho, N Hirohashi, WS Kong, G Yun, K Ota, J Itai, S Yamaga, K Suzuki, K Tanigawa, M Kanno, N Shime Sera from Septic Patients Contain the Inhibiting Activity of the Extracellular ATP-Dependent Inflammasome Pathway Tohoku J. Exp. Med., 2018-07-01;245(3):193-204. 2018-07-01 [PMID: 30033950] (Human)		Human
T Wakamatsu, S Yamamoto, T Ito, Y Sato, K Matsuo, Y Takahashi, Y Kaneko, S Goto, JJ Kazama, F Gejyo, I Narita Indoxyl Sulfate Promotes Macrophage IL-1? Production by Activating Aryl Hydrocarbon Receptor/NF-?/MAPK Cascades, but the NLRP3 inflammasome Was Not Activated Toxins (Basel), 2018-03-15;10(3):. 2018-03-15 [PMID: 29543732] (Human)		Human
A Bandera, M Masetti, M Fabbiani, M Biasin, A Muscatello, N Squillace, M Clerici, A Gori, D Trabattoni The NLRP3 Inflammasome Is Upregulated in HIV-Infected Antiretroviral Therapy-Treated Individuals with Defective Immune Recovery Front Immunol, 2018-02-12;9(0):214. 2018-02-12 [PMID: 29483915] (Human)		Human
S Dubey, H Yoon, MS Cohen, P Nagarkatti, M Nagarkatti, D Karan Withaferin A Associated Differential Regulation of Inflammatory Cytokines Front Immunol, 2018-02-09;9(0):195. 2018-02-09 [PMID: 29479354] (Human)		Human
Y Han, X Xu, C Tang, P Gao, X Chen, X Xiong, M Yang, S Yang, X Zhu, S Yuan, F Liu, L Xiao, YS Kanwar, L Sun Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis Redox Biol, 2018-02-15;16(0):32-46. 2018-02-15 [PMID: 29475133] (Human)		Human
S Dabo, P Maillard, M Collados R, MD Hansen, S Mazouz, DJ Bigot, M Tible, G Janvier, O Helynck, P Cassonnet, Y Jacob, J Bellalou, A Gatignol, RC Patel, J Hugon, H Munier-Leh, EF Meurs Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT Sci Rep, 2017-11-23;7(1):16129. 2017-11-23 [PMID: 29170442] (Human)		Human
F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2 Sci Rep, 2016-07-19;6(0):29834. 2016-07-19 [PMID: 27431477] (Human)		Human
JH Kim, HJ Sohn, JK Yoo, H Kang, GS Seong, YJ Chwae, K Kim, S Park, HJ Shin NLRP3 Inflammasome Activation in THP-1 Target Cells Triggered by Pathogenic Naegleria fowleri Infect. Immun, 2016-08-19;84(9):2422-8. 2016-08-19 [PMID: 27297387] (Human)		Human
Shamaa O, Mitra S, Gavrilin M, Wewers M Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1. PLoS ONE, 2015-11-24;10(11):e0142203. 2015-11-24 [PMID: 26599267] (Human)		Human
Deng Q, Wang Y, Zhang Y, Li M, Li D, Huang X, Wu Y, Pu J, Wu M Pseudomonas aeruginosa Triggers Macrophage Autophagy To Escape Intracellular Killing by Activation of the NLRP3 Inflammasome. Infect Immun, 2015-10-14;84(1):56-66. 2015-10-14 [PMID: 26467446] (Human)		Human
Cox R, Phillips O, Fukumoto J, Fukumoto I, Tamarapu Parthasarathy P, Mandry M, Cho Y, Lockey R, Kolliputi N Resolvins Decrease Oxidative Stress Mediated Macrophage and Epithelial Cell Interaction through Decreased Cytokine Secretion. PLoS ONE, 2015-08-28;10(8):e0136755. 2015-08-28 [PMID: 26317859] (Human)		Human
Datta-Mitra A, Kundu-Raychaudhuri S, Mitra A, Raychaudhuri S Cross talk between neuroregulatory molecule and monocyte: nerve growth factor activates the inflammasome. PLoS ONE, 2015-04-15;10(4):e0121626. 2015-04-15 [PMID: 25876154] (Human)		Human
Shenker B, Ojcius D, Walker L, Zekavat A, Scuron M, Boesze-Battaglia K Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3 inflammasome in human macrophages, leading to the release of proinflammatory cytokines. Infect Immun, 2015-02-02;83(4):1487-96. 2015-02-02 [PMID: 25644004] (Human)		Human
Westbom C, Shukla A, MacPherson M, Yasewicz E, Miller J, Beuschel S, Steele C, Pass H, Vacek P, Shukla A CREB-induced inflammation is important for malignant mesothelioma growth. Am J Pathol, 2014-08-08;184(10):2816-27. 2014-08-08 [PMID: 25111229] (Human)		Human
Exline M, Justiniano S, Hollyfield J, Berhe F, Besecker B, Das S, Wewers M, Sarkar A Microvesicular caspase-1 mediates lymphocyte apoptosis in sepsis. PLoS ONE, 2014-03-18;9(3):e90968. 2014-03-18 [PMID: 24643116] (Human)		Human
Wu M, Chen S, Yang A, Lin W, Lin Y, Chen N, Tsai I, Li L, Hsieh S CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood, 2012-11-14;121(1):95-106. 2012-11-14 [PMID: 23152543] (Human)		Human
Huang T, Ojcius D, Young J, Wu Y, Ko Y, Wong T, Wu C, Lu C, Lai H The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1beta production and activates the NLRP3 inflammasome in human macrophages. PLoS ONE, 2012-07-23;7(7):e41383. 2012-07-23 [PMID: 22844468] (Human)		Human
Beynon V, Quintana FJ, Weiner HL Activated Human CD4+CD45RO+ Memory T-Cells Indirectly Inhibit NLRP3 Inflammasome Activation through Downregulation of P2X7R Signalling. PLoS ONE, 2012-06-29;7(6):e39576. 2012-06-29 [PMID: 22768094] (Human)		Human
Kuijk LM, Beekman JM, Koster J, Waterham HR, Frenkel J, Coffer PJ HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation. Blood, 2008-08-06;112(9):3563-73. 2008-08-06 [PMID: 18684863] (Human)		Human
Blankenberg S, Godefroy T, Poirier O, Rupprecht HJ, Barbaux S, Bickel C, Nicaud V, Schnabel R, Kee F, Morrison C, Evans A, Lackner KJ, Cambien F, Munzel T, Tiret L Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk. Circ. Res., 2006-06-15;99(1):102-8. 2006-06-15 [PMID: 16778130] (Human)		Human
Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. Clin. Cancer Res., 2006-01-15;12(2):376-82. 2006-01-15 [PMID: 16428475] (Human)		Human
Grandjean-Laquerriere A, Laquerriere P, Laurent-Maquin D, Guenounou M, Phillips TM The effect of the physical characteristics of hydroxyapatite particles on human monocytes IL-18 production in vitro. Biomaterials, 2004-12-01;25(28):5921-7. 2004-12-01 [PMID: 15183606] (Human)		Human
Dziankowska-Bartkowiak B, Waszczykowska E, Zalewska A, Sysa-Jedrzejowska A Evaluation of caspase 1 and sFas serum levels in patients with systemic sclerosis: correlation with lung dysfunction, joint and bone involvement. Mediators Inflamm., 2003-12-01;12(6):339-43. 2003-12-01 [PMID: 14668093] (Human)		Human
Cloez-Tayarani I, Petit-Bertron AF, Venters HD, Cavaillon JM Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors. Int. Immunol., 2003-02-01;15(2):233-40. 2003-02-01 [PMID: 12578853] (Human)		Human
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Human Caspase-1/ICE Quantikine ELISA Kit

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