Human APP DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Amyloid Precursor Protein (APP) is a type I transmembrane protein that is ubiquitously expressed on cell surfaces. It undergoes complex proteolytic processing and is cleaved by alpha-, beta-, and gamma-Secretases to generate soluble APP alpha, soluble APP beta, and Amyloid beta (A beta) fragments of several lengths. One of these fragments, A beta 42, generated by beta- and gamma-Secretase activities, has been implicated in Alzheimer's disease. Aberrantly high levels of this peptide form and accumulate in the brains of Alzheimer's disease patients to create the senile plaques characteristic of the disease.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 5 of 5.

Publications using DY850	Applications	Species
DD Limbrick, DM Morales, CN Shannon, JC Wellons, AV Kulkarni, JS Alvey, RW Reeder, V Freimann, R Holubkov, JK Riva-Cambr, WE Whitehead, CJ Rozzelle, M Tamber, WJ Oakes, JM Drake, IF Pollack, RP Naftel, TE Inder, JR Kestle, Hydrocepha Cerebrospinal fluid NCAM-1 concentration is associated with neurodevelopmental outcome in post-hemorrhagic hydrocephalus of prematurity PLoS ONE, 2021-03-10;16(3):e0247749. 2021-03-10 [PMID: 33690655] (Human)		Human
K Lashkari, GC Teague, U Beattie, J Betts, S Kumar, MM McLaughlin, FJ López Plasma biomarkers of the amyloid pathway are associated with geographic atrophy secondary to age-related macular degeneration PLoS ONE, 2020-08-07;15(8):e0236283. 2020-08-07 [PMID: 32764794] (Human)		Human
DD Limbrick, B Baksh, CD Morgan, G Habiyaremy, JP McAllister, TE Inder, D Mercer, DM Holtzman, J Strahle, MJ Wallendorf, DM Morales Cerebrospinal fluid biomarkers of infantile congenital hydrocephalus PLoS ONE, 2017-02-17;12(2):e0172353. 2017-02-17 [PMID: 28212403] (Human)		Human
Morales , Diego M, Holubkov , Richard, Inder , Terri E, Ahn , Haejun C, Mercer , Deanna, Rao , Rakesh, McAllister , James P, Holtzman , David M, Limbrick , David D Cerebrospinal fluid levels of amyloid precursor protein are associated with ventricular size in post-hemorrhagic hydrocephalus of prematurity. PLoS ONE, 2015-03-04;10(3):e0115045. 2015-03-04 [PMID: 25738507] (Human)		Human
Barnwell E, Padmaraju V, Baranello R, Pacheco-Quinto J, Crosson C, Ablonczy Z, Eckman E, Eckman C, Ramakrishnan V, Greig N, Pappolla M, Sambamurti K Evidence of a novel mechanism for partial gamma-secretase inhibition induced paradoxical increase in secreted amyloid beta protein. PLoS ONE, 2014-03-21;9(3):e91531. 2014-03-21 [PMID: 24658363] (Human)		Human

Array DY850

• APP Antibodies
• APP ELISA Kits
• APP Lysates
• APP Proteins
• APP Proteins and Enzyme
• APP ELISA