TCIRG1 Antibody (6H3)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 5 of 5.

Publications using H00010312-M01	Applications	Species
X Xian, R Moraghebi, H Löfvall, A Fasth, K Henriksen, J Richter, NB Woods, I Moscatelli Generation of gene-corrected functional osteoclasts from osteopetrotic induced pluripotent stem cells Stem Cell Res Ther, 2020-05-15;11(1):179. 2020-05-15 [PMID: 32414402]
Capo V, Penna S, Merelli I et al. Expanded circulating hematopoietic stem/progenitor cells as novel cell source for the treatment of TCIRG1 osteopetrosis. Haematologica. 2020-01-16 [PMID: 31949009]
Henriksen K, Andreassen KV, Thudium CS et al. A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts. Bone. 2012-06-19 [PMID: 22722081]
Schinke T, Schilling AF, Baranowsky A et al. Impaired gastric acidification negatively affects calcium homeostasis and bone mass. Nat Med. 2009-06-01 [PMID: 19448635]
Schulz N, Dave MH, Stehberger PA et al. Differential Localization of Vacuolar H+-ATPases Containing a1, a2, a3, or a4 (ATP6V0A1-4) Subunit Isoforms Along the Nephron. Cell Physiol Biochem;20(1-4):109-20. 2007-01-01 [PMID: 17595521]

Array H00010312-M01

• TCIRG1 Antibodies
• TCIRG1 ELISA Kits
• TCIRG1 Lysates
• TCIRG1 Proteins