Human Acetylcholinesterase/ACHE DuoSet ELISA, 5 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The classical role of ACHE is to terminate cholinergic neurotransmission by hydrolysis of acetylcholine (ACH). ACHE is thought to be involved in the pathology of Alzheimer's disease (AD) by accelerating the assembly of Abeta peptides into fibrillar species through forming complexes with Abeta via the peripheral anionic site on ACHE. ACHE inhibitors have been used to delay symptoms of AD patients by virtue of their ability to enhance ACH availability, as well as reduce amyloidogenesis and subsequent neurotoxicity. Its involvement in the cholinergic anti-inflammatory pathway connects ACHE with a possible marker of low-grade systemic inflammation in obesity, hypertension, coronary heart disease, and AD. Alternative splicing produces three isoforms: an amphipathic form that exists as both monomeric and mutimeric forms, a soluble-monomeric form lacking the cysteine residue near the C-terminus, and a GPI-anchored dimeric form found in the membranes of erythrocytes. The recombinant mouse ACHE (rmACHE) was expressed as the amphipathic form that consists of soluble monomer and mutimeric forms.

We have publications tested in 2 confirmed species: Human, Rat.

Showing Publications 1 - 3 of 3.

Publications using DY7574-05	Applications	Species
Mahmoud, AH;Elhefnawei, DM;El-Desouky, MA;Kadry, MO; Reciprocal crosslink among MeCP2/BDNF /CREB signaling pinpointed in autism spectrum disorder Toxicology reports 2024-06-01 [PMID: 38229920] (Rat)		Rat
EDE Papathanas, Y Skrobik, K Hegadoren, P Thompson, HT Stelfox, C Norris, L Rose, SM Bagshaw, M Meier, C LoCicero, R Ashmore, T Sparrow Br, I Hassan, T Park, DJ Kutsogiann Relaxation for Critically ill Patient Outcomes and Stress-coping Enhancement (REPOSE): a protocol for a pilot randomised trial of an integrative intervention to improve critically ill patients' delirium and related outcomes BMJ Open, 2019-01-15;9(1):e023961. 2019-01-15 [PMID: 30782719] (Human)		Human
X Zhao, J Li, Y Meng, M Cao, J Wang Treatment Effects of Jinlingzi Powder and Its Extractive Components on Gastric Ulcer Induced by Acetic Acid in Rats Evid Based Complement Alternat Med, 2019-01-03;2019(0):7365841. 2019-01-03 [PMID: 30719066] (Rat)		Rat

Array DY7574-05

• Acetylcholinesterase/ACHE Antibodies
• Acetylcholinesterase/ACHE ELISA Kits
• Acetylcholinesterase/ACHE Kits
• Acetylcholinesterase/ACHE Lysates
• Acetylcholinesterase/ACHE Protein
• Acetylcholinesterase/ACHE Proteins and Enzymes
• Acetylcholinesterase/ACHE ELISA