HSP90 Antibody (AC88)

In mammalian cells there are at least two Hsp90 isoforms, Hsp90a and Hsp90b which are encoded by separate genes. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cells powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by nonphysiological conditions. However, in the absence of stress, Hsp90 is a necessary component of fundamental cellular processes such as hormone signaling and cell cycle control. In this context several key regulatory proteins such as steriod receptors, cell cycle kinases involved in signal transduction and p53 have been identified as substrates of Hsp90. It has been suggested that Hsp90 acts as a capacitor for morphological evolution by buffering widespread variation, which may affect morphogenic pathways.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: FLOW, ICC/IF, WB.

Showing Publications 1 - 7 of 7.

Publications using NB100-1972	Applications	Species
Onay Ucar E, Sengelen A, Mertoglu Kamali E Hsp27, Hsp60, Hsp70, or Hsp90 depletion enhances the antitumor effects of resveratrol via oxidative and ER stress response in human glioblastoma cells Biochemical Pharmacology 2023-02-01 [PMID: 36603687] (WB, Human) Details: 1:1000 WB dilution	WB	Human
Panagioti E, Kurokawa C, Viker K Et Al. Immunostimulatory bacterial antigen-armed oncolytic measles virotherapy significantly increases the potency of anti-PD1 checkpoint therapy The Journal of clinical investigation 2021-07-01 [PMID: 34196308] (FLOW)	FLOW
Freund E, Miebach L, Stope MB, Bekeschus S Hypochlorous acid selectively promotes toxicity and the expression of danger signals in human abdominal cancer cells Oncology reports 2021-05-01 [PMID: 33760187] (FLOW, Human)	FLOW	Human
Mohamed H, Clemen R, Freund E et al. Non-thermal plasma modulates cellular markers associated with immunogenicity in a model of latent HIV-1 infection PloS one 2021-03-01 [PMID: 33647028]
Bekeschus S, Clemen R, Niebner F et al. Medical Gas Plasma Jet Technology Targets Murine Melanoma in an Immunogenic Fashion Adv. Sci. 2020-03-30 [PMID: 32440479]
Bekeschus S, Freund E, Wende k et al. Hmox1 Upregulation Is a Mutual Marker in Human Tumor Cells Exposed to Physical Plasma-Derived Oxidants. Antioxidants (Basel). 2018-10-27 [PMID: 30373228] (ICC/IF, Human)	ICC/IF	Human
Kelly RL, Geoghegan JC, Feldman J et al. Chaperone proteins as single component reagents to assess antibody nonspecificity MAbs 2017-07-26 [PMID: 28745541] (Mouse)		Mouse

Array NB100-1972

• HSP90 Antibodies
• HSP90 ELISA Kits
• HSP90 Proteins