HMGB1/HMG-1 Antibody (2F6)

This product is produced by and distributed for Abnova, a company based in Taiwan.

HMGB1 and HMGB2 are part of the chromatin non-histone high mobility group proteins 1 and 2. HMGB1 and HMGB2 (containing multiple HMG-boxes) are conserved domains of 80 amino acids which mediate the DNA binding of many proteins. HMG box domains recognize DNA structure. Both HMGB1 and HMGB2 contain a N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of HMGB1 and HMGB2 contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMGB1 and HMGB2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites. HMGB1 and HMGB2 may also serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription, and replication.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: B/N, ICC/IF, In vivo assay, KD, WB.

Showing Publications 1 - 10 of 16. Show All 16 Publications. Collapse Publications.

Publications using H00003146-M08	Applications	Species
Bhuyan S, Pal B, Pathak L, Saikia P, Mitra S, Gayan S, Mokhtari R, Li H, Ramana C, Baishya D, Das B Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense. Front Immunol, 2022-09-29;13(0):933329. 2022-09-29 [PMID: 36248858]
Liu L, Liu S, Luo H et al. GPR30-mediated HMGB1 upregulation in CAFs induces autophagy and tamoxifen resistance in ER?-positive breast cancer cells Aging (Albany NY) 2021-06-30 [PMID: 34182538] (In vivo assay)	In vivo assay
Yang L, Ye F, Zeng L et al. Knockdown of HMGB1 Suppresses Hypoxia-Induced Mitochondrial Biogenesis in Pancreatic Cancer Cells Onco Targets Ther 2020-02-12 [PMID: 32103987] (WB, KD, Human)	WB, KD	Human
Ye F, Chai W, Xie M HMGB1 regulates erastin-induced ferroptosis via RAS-JNK/p38 signaling in HL-60/NRASQ61L cells Am J Cancer Res 2019-04-01 [PMID: 31105999] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Livezey M, Huang R, Hergenrother PJ, Shapiro DJ. Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death Cell Death Differ. 2018-06-13 [PMID: 29899383] (WB, Human)	WB	Human
Chen X, Ma J, Kwan T et al. Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice. Sci Rep 2018-05-29 [PMID: 29844451]
Xie Yangchun, Zhu Shan, Zhong Meizuo et al. Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma. Gastroenterology 2017-07-02 [PMID: 28764929] (WB, Human)	WB	Human
Di Candia L, Gomez E, Venereau E et al. HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4. J Allergy Clin Immunol 2017-02-23 [PMID: 28259445]
Yu Y, Xie Y, Cao L et al. The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents. Mol Cell Oncol 2015-10-01 [PMID: 27308510] (WB)	WB
Yang M, Liu L, Xie M et al. Poly-ADP-ribosylation of HMGB1 regulates TNFSF10/TRAIL resistance through autophagy Autophagy. 2015-01-21 [PMID: 25607248]
Amornsupak K, Insawang T, Thuwajit P et al. Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells. BMC Cancer. 2015-01-08 [PMID: 25512109] (B/N, Human)	B/N	Human
Livesey KM, Kang R, Vernon P, Buchser W, Loughran P, Watkins SC, Zhang L, Manfredi JJ, Zeh HJ 3rd, Li L, Lotze MT, Tang D. p53/HMGB1 Complexes Regulate Autophagy and Apoptosis. Cancer Res;72(8):1996-2005. 2012-04-15 [PMID: 22345153] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Tang D, Kang R, Livesey KM et al. High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress. Antioxid Redox Signal. 2011-10-15 [PMID: 21395369] (B/N)	B/N
Kang R, Tang D, Livesey KM et al. The Receptor for Advanced Glycation End-products (RAGE) protects pancreatic tumor cells against oxidative injury. Antioxid Redox Signal. 2011-10-15 [PMID: 21126167] (B/N, Human)	B/N	Human
Gong W, Zheng Y, Chao F et al. The anti-inflammatory activity of HMGB1 A box is enhanced when fused with C-terminal acidic tail. J Biomed Biotechnol:915234. 2010-01-01 [PMID: 20379370]
Zhou J, Huang JD, Poon VK et al. Functional dissection of an IFN-alpha/beta receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection. J Hepatol. 2009-05-03 [PMID: 19501422]
Show All 16 Publications. Collapse Publications.

Array H00003146-M08

• HMGB1/HMG-1 Antibodies
• HMGB1/HMG-1 Antibody Pair
• HMGB1/HMG-1 ELISA Kits
• HMGB1/HMG-1 Lysate
• HMGB1/HMG-1 Proteins
• HMGB1/HMG-1 Proteins and Enzyme